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Orioles vs Pirates Prediction 4/4/2026 Today’s MLB Picks

Mar 29, 2026; Baltimore, Maryland, USA; Baltimore Orioles pitcher Shane Baz (34) throws during the first inning against the Minnesota Twins at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

Mar 29, 2026; Baltimore, Maryland, USA; Baltimore Orioles pitcher Shane Baz (34) throws during the first inning against the Minnesota Twins at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

MATCHUP Baltimore Orioles Pittsburgh Pirates
Team Records 3-5 5-3
Where PNC Park, Pittsburgh, Pennsylvania
When Saturday, April 4, 2026
Time 04:05 PM EDT
TV MLB.TV

In this article we will formulate an Orioles vs Pirates prediction for this MLB game on Saturday, April 4th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 3-4 this season after they lost game one against the Pirates by a score of 5-4 on Friday afternoon. Baltimore trailed 4-0 in the fifth inning, but they did score four runs over the last five innings, before falling just short. The Orioles recorded nine hits in the game and they were led by Henderson, who went 3-5 with one home run and two RBIs. Bradish allowed six hits and four earned runs over 4.0 innings for the loss, while Enns allowed one earned run in relief. 

This season, Baltimore has a 4.50 ERA with a 1.39 WHIP and a .244 opponent batting average, while they have scored 30 runs with a .257 batting average and a .336 on base percentage. Gunnar Henderson has led the Orioles with two home runs and six RBIs, while Tyler O’Neill has added one home run and three RBIs. The projected starting pitcher for Baltimore is Shane Baz, who is 0-0 with a 6.75 ERA and a 1.31 WHIP over 5.1 innings pitched this season. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 4-3 this year after they opened this series with a 5-4 win in game one. Pittsburgh scored four runs in the first two innings, but they only scored one run over the last six innings and nearly blew the game late. The Pirates recorded six hits in the game and they were led by Cruz, O’Hearn, Griffin, Triolo, and Davis, who all had one RBI. Keller allowed six hits and two earned runs over 6.0 innings for the win, while Soto picked up the save in the ninth. 

This season, Pittsburgh has a 3.71 ERA with a 1.38 WHIP and a .217 opponent batting average, while they have scored 34 runs with a .230 batting average and a .320 on base percentage. Oneil Cruz has led the Pirates with three home runs and seven RBIs, while Ryan O’Hearn has added two home runs and seven RBIs. The projected starting pitcher for Pittsburgh is Carmen Mlodzinski, who is 0-0 with a 4.15 ERA and a 1.38 WHIP over 4.1 innings pitched this year. 

Why the Pittsburgh Pirates will win

Why the Baltimore Orioles will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Baltimore Orioles Player Prop Facts

Orioles vs Pirates Prediction 

Pittsburgh comes into this matchup on a three game winning streak and they have scored 21 runs during that span. The Pirates are starting Mlodzinski, who is very average in my opinion. Baltimore has lost three of their last four games, but they have scored at least four runs in four of their last five. The Orioles are going with Baz, who struggled in his first start, but I think he is going to bounce back for a solid season. Baltimore gained some momentum late in game one and I like them to win game two here.

David Racey's Pick: Orioles ML

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