Orioles vs Guardians Prediction 07/23/2025 Picks

In this article, we will formulate an Orioles vs Guardians prediction for this MLB game on Wednesday, July 23rd at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 44-56 this season after they lost the first two games in this series by scores of 5-10 and 3-6. In their game two loss, Baltimore cut the deficit to 3-2 in the sixth inning, but they couldn’t get any closer in the loss. The Orioles recorded seven hits in the game, and they were led by Laureano and Holliday, who both had one RBI in the loss. Baltimore started Young, who allowed four hits and three earned runs over 4.1 innings for the loss, while Soto allowed two earned runs in relief. 

Prior to this series, the Orioles lost two out of three against the Rays and two out of three against the Marlins. Baltimore has lost six of their last seven games, and they are currently last in the AL East standings. The Baltimore pitching staff has a 5.02 ERA with a 1.43 WHIP and a .268 opponent batting average, while their offense has scored 410 runs with a .239 batting average and a .303 on base percentage this season. Cedric Mullins has led Baltimore with 13 home runs and 42 RBIs, while Jackson Holliday has added 13 home runs and 40 RBIs this year. The projected starting pitcher for Baltimore is Charlie Morton, who is 5-8 with a 5.58 ERA and a 1.56 WHIP over 88.2 innings pitched this season. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 50-50 this year after they won game two on Tuesday night by a score of 6-3. Cleveland scored two runs in the bottom of the sixth to pull away, and they added an insurance run in the seventh to seal the victory. The Guardians recorded seven hits in the game, and they were led by Manzardo and Rocchio, who both had two RBIs in the win. Cleveland started Cantillo, who allowed two hits and one earned run over 5.0 innings for the win, while Clase picked up the save. 

Prior to this series, the Guardians won two out of three against the Athletics and three out of four against the White Sox. Cleveland has won 10 of their last 12 games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 3.94 ERA with a 1.33 WHIP and a .245 opponent batting average, while the offense has scored 387 runs with a .225 batting average and a .298 on-base percentage this season. Jose Ramirez has led Cleveland with 21 home runs and 56 RBIs, while Kyle Manzardo has added 16 home runs and 40 RBIs this year. The projected starting pitcher for Cleveland is Slade Cecconi, who is 5-4 with a 3.84 ERA and a 1.23 WHIP over 63.1 innings pitched this year. 

Why the Guardians will beat the Orioles

The Orioles have lost each of their last nine games as underdogs against AL Central opponents.
The Guardians have won each of their last seven Wednesday night home games.
The Orioles have failed to cover the run line in each of their last seven road games against AL Central opponents.
The favorites have covered the run line in each of the last four games between the Orioles and Guardians.
The Orioles have trailed after 5 innings in seven of their last nine games as underdogs against AL Central opponents.
The Orioles have trailed after 3 innings in six of their last eight games as road underdogs against AL Central opponents.

Total Runs Facts

Each of the Guardians’ last six home games have gone OVER the total runs line.
Each of the Orioles’ last three games as underdogs against the Guardians have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last six games as underdogs.
The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Guardians’ last six night games against AL East opponents.

Cleveland Guardians Player Prop Facts

Jose Ramirez has hit a home run in four of the Guardians’ last five night games against opponents that held a losing record.
Jose Ramirez has recorded at least one hit in each of the Guardians’ last 11 games at Progressive Field against AL East opponents that held a losing record.

Baltimore Orioles Player Prop Facts

Ramon Laureano has hit a home run in three of the Orioles’ last four road games against AL Central opponents.
Ryan Mountcastle has recorded at least one hit in 12 of his last 13 appearances against AL opponents.

Orioles vs Guardians Prediction 

Cleveland continues to play very well over the last two weeks, and they are starting to make up some serious ground on the Tigers in the Central. The Guardians are 24-24 at home this year, while the Orioles are 22-31 on the road. Baltimore is trending in the opposite direction, and they are starting Morton, who has been better over the last month, but did get roughed up last time out. The Guardians are starting Cecconi, who has allowed two earned runs or fewer in three of his last five starts. This Cleveland team is playing at a very high level right now, and I like them at home.