Oakland (64-75) vs St. Louis (68-71)
September 2, 2025 at 07:45 PM EDT
The Line: Betting Odds: St. Louis -109 — Over/Under: +8
In this article, we will formulate an Athletics vs Cardinals Prediction for this MLB game on Tuesday, September 2nd at the Busch Stadium in the second game of this series, with the Athletics having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.
Saint Louis Cardinals Preview
The Saint Louis Cardinals have a 68-71 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 37-33 home record and are 71-60 in over/under. They are coming off a 3-11 home defeat by the A’s, and have back-to-back losses. Over is 7-3-1 in their last 11 games and are playing the Giants and the Mariners next.
The Cardinals have a .247 batting average this season, .316 OBP and .383 Slugging percentage. Saint Louis’ pitching staff has a 4.30 ERA and 1.31 WHIP. Alec Burleson leads the Cardinals with 123 hits, and he is the team’s best hitter with a .286 batting average. Wilson Contreras leads the team in RBI, with 74, adding a team-high 20 home runs.
Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has a 6-10 record, 5.04 ERA and 1.35 WHIP.
Athletics Preview
The Athletics have a 64-75 record this season and are sitting on the last place of the AL West. The Athletics have a 35-35 road record and are 71-62 in over/under. They are coming off a 11-3 road victory over the Cardinals, that ended their three-game losing streak. Over is 6-2 in their last 8 games and are playing the Red Sox and the Angels next.
The Athletics have a .254 batting average this season, .319 OBP and .434 Slugging percentage. Athletics’ pitching staff has a 4.82 ERA and 1.37 WHIP. Brent Rooker leads the Athletics with 146 hits, while Jacob Wilson is the team’s best hitter with a .318 batting average. Tyler Soderstrom adds a team-high 81 RBI, while Shea Langeliers adds a team-high 29 home runs.
Luis Severino (R) is the projected starter for the Athletics, and he has a 6-11 record, 4.82 ERA, and 1.34 WHIP.
Why the St. Louis Cardinals will win
The Athletics have lost each of their last eight games as underdogs against National League opponents following a win.
The Cardinals have won four of their last five games against AL West opponents following a home loss.
The Athletics have failed to cover the run line in each of their last eight games as underdogs against National League opponents following a win.
The Cardinals have covered the run line in four of their last five games as favorites against American League opponents.
The Cardinals have led after 5 innings in four of their last five games as favorites against American League opponents.
The Athletics have trailed after 3 innings in each of their last four night games against NL Central opponents.
Why the Athletics will win
The Cardinals have lost each of their last eight home games against American League opponents.
The Athletics have won each of their last six road games against teams that held a losing record.
The Athletics have covered the run line each of their last eight road games against teams that held a losing record.
The Cardinals have failed to cover the run line in each of their last seven games as home favorites against American League opponents.
The Cardinals have trailed after 5 innings in each of their last seven games as home favorites against American League opponents.
The Cardinals have lost the first inning in 10 of their last 11 night games against American League opponents.
The Athletics have led after 3 innings in each of their last seven Tuesday games.
Total Runs Facts
Nine of the Cardinals’ last 10 games as favorites against AL West opponents have gone OVER the total runs line.
Six of the Athletics’ last seven games as underdogs have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in 11 of the Athletics’ last 12 night games against National League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Cardinals’ last 11 night games against American League opponents.
Matchup/League Facts
The Cardinals rank 30th in the league for triples this season (6).
The Cardinals rank 29th in the league for strikeouts this season (1028).
The Athletics rank 2nd in the league for doubles this season (255).
The Athletics rank 29th in the league for home runs allowed this season (196).
Athletics vs Cardinals Prediction
The Cardinals are 4-3 in their last 7 head-to-head meetings against the Athletics, but the Athletics are 3-2 in their last 5 meetings in Saint Louis. Under is 4-2 in their last 6 meetings.
In this Athletics vs Cardinals Prediction, both teams are coming at a pickem price. I don’t like either pitcher in this matchup, as they have both been below mediocre this season, with a combined 9.86 ERA. Both teams are better against right-handed pitching, averaging 9.2 runs per game combined, and both teams have been playing some higher-scoring games lately, as they are 13-5-1 to the over in their last 19 games combined. The opening game of this series had 14 total runs, and with the total set at just 8 runs for today, I will go over that number.