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Oakland Athletics vs San Francisco Giants Prediction 5/16/25 MLB Picks

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San Francisco Giants (25-19) vs Oakland Athletics (22-22)

Game Info: Friday, May 16, 2025 at 10:15 pm (Oracle Park)

The Line: Betting Odds: San Francisco Giants -180 / Oakland Athletics +150 — Over/Under: 7

(Get latest betting odds)

The Athletics are visiting the San Francisco Giants on Friday, May 16th at the Oracle Park in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs San Francisco Giants Prediction. We will examine:

The San Francisco Giants’ recent form and player performance

The Athletics’ recent form and player performance

Recent betting trends and streaks involving the San Francisco Giants

Recent betting trends and streaks involving the Athletics

Recent betting trends in games played between the Athletics vs San Francisco Giants

A summary that ties it all together and produces a favorable betting outcome for the Athletics vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 25-19 record this season and are sitting in third place in the NL West. They have a 13-7 home record and are 26-18 in over/under. They are coming off a 7-8 home defeat by the Arizona Diamondbacks, and are 1-5 in their last 6 games. Over is 3-1 in their last 4 games, and they are playing the Nationals and the Royals next.

The Giants have a .237 batting average this season, a .312 OBP, and a .386 Slugging percentage. San Francisco’s pitching staff has a 3.56 ERA and 1.25 WHIP.  Jung Hoo Lee leads the Giants with 48 hits, while Wilmer Flores leads the team in RBI with 33, and Matt Chapman adds a team-high 8 home runs. Heliot Ramos is the team’s best hitter, with a .288 batting average

Logan Webb (R) will take the mound for the Giants, and he has a 4-3 record, 2.60 ERA, and 1.16 WHIP. He has been lights out at home, with just one earned run in 20.1 innings pitched across three home starts. His only start against the A’s last season was a shutout performance, with zero earned runs across 9 innings pitched as the Giants won 1-0.  

Athletics Preview

The Athletics have a 22-22 record this season and are sitting in 4th place in the AL West. The Athletics have a 14-9 road record and are 23-17 in over/under. They are coming off a 2-19 road defeat by the Dodgers, and are 2-6 in their last 8 games. Over is 6-1 in their last 7 games, and they are playing the Phillies and the Angels next.

The Athletics have a .258 batting average this season, a .317 OBP, and a .428 Slugging percentage. Athleticspitching staff has a 5.18 ERA and 1.50 WHIP. Jacob Wilson leads the Athletics with 58 hits and a team-high .347 batting average. Tyler Soderstrom leads the team with 29 RBI.

JP Sears (L) will take the mound for the Athletics, and he has a 4-2 record, 2.80 ERA, and 1.00 WHIP. He has been better on the road, with a 2.32 ERA, and he has not given up more than 2 runs in each of his last five starts. He was excellent against the Giants last season, giving up only one run in 14.2 innings pitched across two starts.  

Why the San Francisco Giants will win

Why the Athletics will win

Total Runs Facts

Matchup/League Facts

Athletics vs San Francisco Giants Prediction

The Athletics are 4-2 in their last 6 overall meetings against the Giants, but the Giants are 3-1 in their last 4 meetings in San Francisco. All four of their meetings last season went under the total, with 4 average total runs. 

In this Athletics vs San Francisco Giants Prediction, the Giants are coming as home favorites. Both pitchers have been outstanding to start the season, with a combined 5.40 ERA. The Giants have the best bullpen in the MLB, and are much weaker against lefties, with just 3.6 runs per game. Their four meetings last season had only 4 average total runs, and I like another under here. Take the under 7 runs.

Nikos Lagouretos's Pick: Under 7

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