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New York Yankees vs St. Louis Cardinals Prediction 8/17/2025 Today’s MLB Picks

Aug 16, 2025; St. Louis, Missouri, USA;  New York Yankees third baseman Ryan McMahon (19) dives and fields ground ball hit by St. Louis Cardinals shortstop Masyn Winn (not pictured) during the ninth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Aug 16, 2025; St. Louis, Missouri, USA; New York Yankees third baseman Ryan McMahon (19) dives and fields ground ball hit by St. Louis Cardinals shortstop Masyn Winn (not pictured) during the ninth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP New York Yankees St. Louis Cardinals
Team Records 67-57 61-64
Where Busch Stadium, St. Louis, Missouri
When Sunday, August 17, 2025
Time 02:15 PM EDT
TV YES

The New York Yankees and St. Louis Cardinals meet Sunday in MLB action at Busch Stadium. Here’s a New York Yankees vs St. Louis Cardinals Prediction. This article will include a New York Yankees vs St. Louis Cardinals Pick.

New York Yankees Betting Preview

The New York Yankees are 66-57 on the year and play the Rays, Red Sox, and Nationals next. The New York Yankees are batting .250 on the season, have a .330 OBP, and a .447 slugging percentage. The New York Yankees pitching staff has a 4.04 ERA and a 1.25 WHIP. Aaron Judge leads the New York Yankees with 136 hits and 91 RBI, while Cody Bellinger and Paul Goldschmidt have combined for 227 hits and 109 RBI. 

Will Warren gets the ball for the New York Yankees, and he is 7-5 with a 4.34 ERA and 140 strikeouts this season. This will be Warren’s second career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 61-63 on the year and play the Marlins, Rays, and Pirates next. The St. Louis Cardinals are batting .250 on the season, have a .318 OBP, and a .383 slugging percentage. The St. Louis Cardinals pitching staff has a 4.25 ERA and a 1.29 WHIP. Brendan Donovan leads the St. Louis Cardinals with 118 hits and 45 RBI while Masyn Winn and Alec Burleson have combined for 223 hits and 100 RBI.

Miles Mikolas gets the ball for the St. Louis Cardinals, and he is 6-9 with a 4.97 ERA and 79 strikeouts this season. Mikolas is 1-0 with a 3.97 ERA and 8 strikeouts in his career against the New York Yankees.

Why the St. Louis Cardinals will win

Why the New York Yankees will win

St. Louis Cardinals Player Prop Facts

New York Yankees Player Prop Facts

New York Yankees vs St. Louis Cardinals Prediction

The Yankees have found their form this week, and they’re throwing out Warren, who has allowed 12 hits and three runs in his last 17.2 innings. The Cardinals are having a week from hell and Mikolas is having an off season with a 4.97 ERA and 1.28 WHIP. Mikolas has allowed 11 hits and seven runs in his last 9.2 innings. The Cardinals have lost seven of Mikolas’ last 11 starts. I have to side with the Yankees for the sweep. 

Randy Chambers's Pick: New York Yankees

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