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New York Yankees vs St. Louis Cardinals Prediction 8/16/2025 Today’s MLB Picks

Aug 15, 2025; St. Louis, Missouri, USA;  St. Louis Cardinals shortstop Masyn Winn (0) leaps to field the throw and tags out New York Yankees left fielder Jasson Dominguez (24) during the third inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Aug 15, 2025; St. Louis, Missouri, USA; St. Louis Cardinals shortstop Masyn Winn (0) leaps to field the throw and tags out New York Yankees left fielder Jasson Dominguez (24) during the third inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP New York Yankees St. Louis Cardinals
Team Records 65-57 61-62
Where Busch Stadium, St. Louis, Missouri
When Saturday, August 16, 2025
Time 07:15 PM EDT
TV FOX

In this article, we will formulate a Yankees vs Cardinals Prediction for this MLB game on Saturday, August 16th at the Busch Stadium in the second game of this series, with the Yankees having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 61-62 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 35-28 home record and are 60-57 in over/under They are coming off a 3-4 home defeat by the Yankees, and have three consecutive losses. Under is 6-2 in their last 8 games and are playing the Marlins and the Rays next.

The Cardinals have a .249 batting average this season, .318 OBP and .386 Slugging percentage. Saint Louis’ pitching staff has a 4.18 ERA and 1.28 WHIP. Brendan Donovan leads the Cardinals with 118 hits, while Alec Burleson is the team’s best hitter with a .279 batting average. Wilson Contreras leads the team in RBI, with 65, adding a team-high 16 home runs.

Sonny Gray (R) is the projected starting pitcher for the Cardinals, and he has a 11-5 record, 4.06 ERA and 1.15 WHIP.

New York Yankees Preview

The New York Yankees have a 65-57 record this season and are sitting on the third place of the AL East. The Yankees have a 28-32 road record and are 54-63 in over/under. They are coming off a 4-3 road victory over the Cardinals, and are 3-1 in their last 4 games. Under is 4-1 in their last 5 games and are playing the Rays and the Red Sox next.

The Yankees have a .249 batting average this season, .329 OBP and .445 Slugging percentage. New York’s pitching staff has a 4.01 ERA and 1.25 WHIP. Aaron Judge leads the Yankees with 134 hits, adding team-highs both in RBI, with 89 and in home runs, with 38. He is also the team’s best hitter, with a .330 batting average.

Max Fried (L) will take the mound for the Yankees, and he has a 12-5 record, 2.94 ERA and 1.10 WHIP.

Why the St. Louis Cardinals will win

Why the New York Yankees will win

Total Runs Facts

Matchup/League Facts

Yankees vs Cardinals Prediction

The Cardinals are 7-3 in their last 10 meetings against the Yankees, and are 5-2 in their last 7 meetings in Saint Louis. Over is 3-1 in their last 4 meetings.

In this Yankees vs Cardinals Prediction, the Yankees are coming as -150 road favorites. Fried has been weaker on the road, and Gray has been better at home, but both pitchers are coming into this matchup in poor form. Fried is currently in his worst stretch of the season, having given up 4 runs in three of his last four starts, and he has a 1-4 record and 6.12 ERA across his last 5 starts. Gray has a 6.26 ERA in his last 5 starts, and both teams average 9.6 runs per game combined. With the total set at 8, which gives up push protection, I will go over the total in this one.

Nikos Lagouretos's Pick: Over 8

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