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New York Yankees vs St. Louis Cardinals Prediction 8/15/2025 Today’s MLB Picks

Aug 13, 2025; Bronx, New York, USA; New York Yankees relief pitcher Brent Headrick (47) attempts to the throws the ball to first base during the ninth inning against the Minnesota Twins at Yankee Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images

Aug 13, 2025; Bronx, New York, USA; New York Yankees relief pitcher Brent Headrick (47) attempts to the throws the ball to first base during the ninth inning against the Minnesota Twins at Yankee Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images

New York (64-57) vs St. Louis (61-61)

August 15, 2025 at 08:15 PM EDT

The Line: Betting Odds: St. Louis +1.5 — Over/Under: +9

(Get latest betting odds)

The New York Yankees and St. Louis Cardinals meet Friday in MLB action at Busch Stadium. Here’s a New York Yankees vs St. Louis Cardinals Prediction. This article will include a New York Yankees vs St. Louis Cardinals Pick.

New York Yankees Betting Preview

The New York Yankees are 64-57 on the year and play the Rays, Red Sox, and Nationals next. The New York Yankees are batting .249 on the season, have a .328 OBP, and a .446 slugging percentage. The New York Yankees pitching staff has a 4.01 ERA and a 1.25 WHIP. Aaron Judge leads the New York Yankees with 134 hits and 88 RBI, while Cody Bellinger and Paul Goldschmidt have combined for 227 hits and 109 RBI. 

Luis Gil gets the ball for the New York Yankees, and he is 0-1 with a 7.27 ERA and 10 strikeouts this season. This will be Gil’s first career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 61-61 on the year and play the Marlins, Rays, and Pirates next. The St. Louis Cardinals are batting .249 on the season, have a .318 OBP, and a .386 slugging percentage. The St. Louis Cardinals pitching staff has a 4.18 ERA and a 1.28 WHIP. Brendan Donovan leads the St. Louis Cardinals with 118 hits and 45 RBI while Masyn Winn and Alec Burleson have combined for 217 hits and 96 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 6-9 with a 4.95 ERA and 80 strikeouts this season. Pallante is 1-0 with a 0.00 ERA and 2 strikeouts in his career against the New York Yankees.

Why the St. Louis Cardinals will win

  • The Cardinals have won each of their last five games as underdogs against American League opponents following a home loss.
  • The Yankees have lost five of their last six games as favorites against National League opponents.
  • The Yankees have failed to cover the run line in each of their last six games as road favorites.
  • The Cardinals have covered the run line in seven of their last eight games as home underdogs against AL East opponents.
  • The Cardinals have led after 3 innings in three of their last four games.

Why the New York Yankees will win

  • The Cardinals have lost seven of their last eight home games against American League opponents that held a winning record.
  • The Yankees have won each of their last three games following a loss.
  • The Cardinals have failed to cover the run line each of their last seven home games against American League opponents that held a winning record.
  • The Yankees have covered the run line in five of their last six games as favorites following a home loss.
  • The Yankees have led after 5 innings in five of their last six night games against NL Central opponents.
  • The Cardinals have trailed after 3 innings in four of their last five games against AL East opponents that held a winning record.

St. Louis Cardinals Player Prop Facts

  • Nolan Arenado has recorded a Double in each of his last three appearances against the Yankees at Busch Stadium.
  • Nolan Arenado has hit a home run in three of the Cardinals’ last five games as home underdogs against AL opponents.
  • Nolan Arenado has recorded at least one hit in each of his last 11 appearances with his team as an underdog against the Yankees.

New York Yankees Player Prop Facts

  • Trent Grisham has hit a home run in three of his last four road appearances with the Yankees against NL opponents.
  • Giancarlo Stanton has recorded at least one hit in each of the Yankees’ last seven road games against NL opponents.
  • Giancarlo Stanton has recorded a Double in each of the Yankees’ last three games as favorites against the Cardinals.
  • Aaron Judge ranks 1st amongst qualified players for Slugging Percentage (.687) this season.

New York Yankees vs St. Louis Cardinals Prediction

It’s hard to back the Yankees with confidence, as they’ve been losing games a lot over the last couple of months. Gil has just 8.2 innings under his belt this season, and he’s allowed 11 hits and seven runs. The Cardinals do just enough winning to be worth a look, but Pallante has allowed 12 hits and eight runs in his last 6.2 innings. In 57 home innings, Pallante has a 5.21 ERA and .263 allowed batting average. Two pitchers in rough shape, I’m going to side with the over. Expect some fireworks. Give me the over. 

Randy Chambers's Pick: Over 9

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