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New York Yankees vs Minnesota Twins Prediction 9/16/2026 Today’s MLB Picks

Jun 28, 2026; Boston, Massachusetts, USA; New York Yankees starting pitcher Carlos Rodon (55) delivers a pitch during the first inning against the Boston Red Sox at Fenway Park. Mandatory Credit: Paul Rutherford-Imagn Images

Jun 28, 2026; Boston, Massachusetts, USA; New York Yankees starting pitcher Carlos Rodon (55) delivers a pitch during the first inning against the Boston Red Sox at Fenway Park. Mandatory Credit: Paul Rutherford-Imagn Images

MATCHUP New York Yankees Minnesota Twins
Team Records 88-63 70-81
Spread -1.5 114 +1.5 -137
Moneyline -148 +123
Total Over 8 (-108) Under 8 (-112)
Where Target Field, Minneapolis, Minnesota
When Wednesday, September 16, 2026
Time 01:40 PM EDT
TV MLB.TV
In this article, we will formulate a Yankees vs Twins Prediction for this MLB matchup on Wednesday, September 16th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview


The Minnesota Twins have a 70-81 record this season and are sitting in the 4th place of the AL Central. They have a 39-38 home record and are coming off a 1-8 home loss against the Yankees. They will face the Angels and the Giants next.

The Minnesota Twins have a .243 batting average this season, .317 OBP and .404 Slugging percentage. Minnesota’s pitching staff has a 4.70 ERA and 1.38 WHIP. Luke Keaschall is the team’s best hitter with a .276 batting average. Josh Bell leads the team in RBI with 87, while Kody Clemens adds a team-high 26 home runs.

Zebby Matthews (R) is the projected starting pitcher for the Twins, and he has a 9-10 record, 4.98 ERA and 1.27 WHIP.

New York Yankees Preview


The New York Yankees have a 88-63 record this season and are sitting in the 2nd place of the AL East. They have a 46-31 away record and are coming off an 8-1 road win against the Twins. They will face the Dbacks and the Rays next.

The New York Yankees have a .236 batting average this season, .312 OBP and .411 Slugging percentage. New York’s pitching staff has a 3.21 ERA and 1.16 WHIP. Cody Bellinger is the team’s best hitter with a .272 batting average. Ben Rice leads the team in RBI with 92, adding a team-high 38 home runs.

Carlos Rodon (L) is the projected starting pitcher for the Yankees, and he has a 6-3 record, 2.94 ERA and 1.12 WHIP.

New York Yankees @ Minnesota Twins Betting Trends: September 16, 2026


Why the Minnesota Twins will win

Why the New York Yankees will win

Total Runs Facts

Minnesota Twins Player Prop Facts

New York Yankees Player Prop Facts

Matchup/League Facts

Yankees vs Twins Prediction


The Yankees are 5-2 in their last 7 meetings against the Twins and have won their last four visits in Minnesota. 

In this Yankees vs Twins Prediction, the Yankees are coming as -170 road favorites. I like the Yankees to keep rolling in this one, as they have the pitching edge with Carlos Rodon on the mound. He has given up one run or less in five of his last six starts, while Matthews has given up 9 runs in his last two starts and has been bad against the Yankees historically. The Twins cannot hit lefties lately and their bullpen has been terrible, so take the Yankees to win this one on the road.

Nikos Lagouretos's Pick: New York Yankees ML

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