New York Yankees vs Houston Astros Prediction 4/25/2026 Today’s MLB Picks
Chris Ruffolo
Apr 24, 2026; Houston, Texas, USA; New York Yankees right fielder Aaron Judge (99) flys out in the fifth inning against the Houston Astros at Daikin Park. Mandatory Credit: Maria Lysaker-Imagn Images
MATCHUP
New York Yankees
Houston Astros
Team Records
17-9
10-17
Where
Daikin Park, Houston, Texas
When
Saturday, April 25, 2026
Time
07:10 PM EDT
TV
MLB.TV
The New York Yankees and the Houston Astros meet Saturday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Yankees vs. Houston Astros prediction.
Starting Pitching Matchup
The New York Yankees will send out Ryan Weathers for the start here and Weathers is 1-2 with a 3.18 ERA and 36 strikeouts this season. This will be Weather’s first career start against the Astros. Mike Burrows will start for Houston here and is 1-3 with a 6.75 ERA and 25 strikeouts this season. This will be Burrows’ first career start against the Yankees.
New York Yankees Recap
The New York Yankees come into this game looking to add on to their 12-4 win over Houston last time out to sit at 17-9 this season. After this series, the Yankees will head on the road for a series against the Rangers.
Yankees Win 7 In A Row
Entering Friday, Giancarlo Stanton has 22 hits with 6 doubles, 3 home runs and 13 RBIs while Ben Rice has 23 hits with 6 doubles, 8 home runs and 18 RBIs and Aaron Judge has 22 hits with 3 doubles, 9 home runs and 17 RBIs. Cody Bellinger also has 23 hits with 3 doubles, a triple, 3 home runs and 13 RBIs. Jazz Chisholm Jr. also has 16 hits with 5 doubles as well on the year.
Houston Astros Recap
The Houston Astros come into this game looking to shake off their loss at the hands of the Yankees in Friday’s matchup to sit at 10-17 on the year. After this series, the Astros will take on the Baltimore Orioles at home.
Astros Alternate Wins & Losses In 5 Straight
Going into Friday’s matchup, Yordan Alvarez has 33 hits with 8 doubles, 11 home runs and 26 RBIs while Christian Walker has 24 hits with 7 doubles, 5 home runs and 18 RBIs on the year. Jose Altuve’s chipped in 25 hits with 6 doubles, 3 home runs and 8 RBIs and Carlos Correa has 25 hits with 6 doubles, a home run and 13 RBIs. Cam Smith also has 21 hits with 5 doubles, 3 home runs and 11 RBIs. Yainer Diaz also has 14 hits with 23 doubles, a home run and 10 RBIs.
New York Yankees @ Houston Astros Betting Trends: April 25, 2026
Probable Starting Pitcher: Mike Burrows Record this season: 1-3 ERA: 6.75
Home Record: 1-1
Last 5 against Yankees: 1-0
Why the Houston Astros will win
The Yankees have lost seven of their last eight games as favorites against AL West opponents following a win.
The Astros have won each of their last seven games against AL East opponents following a home loss.
The Astros have covered the run line in each of their last six games as underdogs against AL East opponents following a loss.
The Yankees have failed to cover the run line in seven of their last eight games as favorites against AL West opponents following a win.
The Astros have won the first inning in three of their last four home games against American League opponents.
The Astros have led after 5 innings in four of their last five night games against AL East opponents.
The Astros have led after 3 innings in each of their last six Saturday night games against AL East opponents that held a winning record.
Probable Starting Pitcher: Ryan Weathers Record this season: 1-2 ERA: 3.18
Road Record: 0-0
Last 5 against Astros: –
Why the New York Yankees will win
The Yankees have won each of their last seven games.
The Astros have lost each of their last five home games.
The Yankees have covered the run line in each of their last seven games.
The Astros have failed to cover the run line in each of their last five home games.
The Yankees have led after 5 innings in each of their last six road games against AL West opponents that held a losing record.
The Astros have trailed after 3 innings in nine of their last 10 night games against opponents that held a winning record.
The Astros have lost the first inning in four of their last five night games.
Total Runs Facts
Each of the Astros’ last nine night games against American League opponents have gone OVER the total runs line.
Six of the Yankees’ last seven night games against American League opponents have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last 12 games as underdogs.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Yankees’ last five games against AL West opponents.
Houston Astros Player Prop Facts
Yordan Alvarez has hit a home run in three of the Astros’ last four home games.
Yordan Alvarez has recorded at least one hit in each of the Astros’ last 13 home games.
Yordan Alvarez ranks 1st in the league in Hits (35) this season.
New York Yankees Player Prop Facts
Jazz Chisholm has hit a home run in each of the Yankees’ last two games.
Paul Goldschmidt has recorded at least one hit in each of his last 10 road appearances against the Astros.
Ben Rice ranks 2nd amongst qualified players for Slugging Percentage (.747) this season.
Matchup/League Facts
The Astros rank 1st in the league for doubles this season (60).
The Astros rank 30th in the league for ERA this season (5.97).
The Yankees rank 1st in the league for ERA this season (3.11).
The Yankees rank 2nd in the league for home runs this season (39).
New York Yankees vs. Houston Astros Prediction
I’m on the Yankees here. I get the case to be made for either side in this game, but I still can’t get there with the Astros and this pitching staff with the way the bullpen continues to struggle and I’m also not trusting Mike Burrows against this Yankee lineup. The Astros historically have been solid against lefties but I think Weathers has a strong enough start to get the win for New York and keep the Yankees rolling along here. Give me the Yankees.
