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New York Mets vs St. Louis Cardinals Prediction 3/30/2026 Today’s MLB Picks

New York Mets left fielder Juan Soto (22) is shown at bat during the fourth inning, Thursday, March 26, 2026.

New York Mets left fielder Juan Soto (22) is shown at bat during the fourth inning, Thursday, March 26, 2026.

MATCHUP New York Mets St. Louis Cardinals
Team Records 2-1 2-1
Spread -1.5 109 +1.5 -131
Moneyline -156 +129
Total Over 8.5 (-122) Under 8.5 (102)
Where Busch Stadium, St. Louis, Missouri
When Monday, March 30, 2026
Time 07:45 PM EDT
TV MLB.TV

The New York Mets and the St. Louis Cardinals meet Monday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Mets vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

Clay Holmes will start this one for the Mets and was 12-8 with a 3.53 ERA and 129 strikeouts last season. In his career, Holmes is 1-0 with a 3.00 ERA and 9 strikeouts against the Cardinals. Kyle Leahy will start this one for the Cardinals and was 4-2 with a 3.07 ERA and 80 strikeouts last season. This will be Leahy’s first career start against the Mets.

New York Mets Recap

The New York Mets come into this game looking to shake off a 4-3 loss at the hands of the Pittsburgh Pirates last time out to sit at 2-1 this season. After this series, the Mets will head on the road again for a series against the San Francisco Giants.

Mets Fail To Complete Sweep

Luis Robert Jr. leads the Mets with 5 hits including a home run and 5 RBIs while Juan Soto has 5 hits with a double and 3 RBIs. Brett Baty has 4 hits with a triple and three RBIs while Francisco Lindor has a pair of hits with a triple as well. Marcus Semien also has a pair of his with a double and two RBIs as well this season. 

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to shake off an 11-7 loss at the hands of Tampa Bay last time out to sit at 2-1 this season. After this series, the Cardinals will head on the road for a series against the Detroit Tigers.

Cardinals Still Win Opening Series

JJ Wetherholt, Alec Burleson and Nolan Gorman all have a team-high 4 RBIs with a home run, while Jordan Walker has 4 hits with 2 doubles, a home run and 3 RBIs. Victor Scott II has a team-high 5 hits while Nathan Church and Pedro Pages each have 2 RBIs and Ivan Herrera has a double with 2 RBIs. 

New York Mets @ St. Louis Cardinals Betting Trends: March 30, 2026

Why the St. Louis Cardinals will win

Why the New York Mets will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

New York Mets Player Prop Facts

Matchup/League Facts

New York Mets vs. St. Louis Cardinals Prediction

I’m on the Mets here. I’m ultimately not that high on the Cardinals as a unit this season and I think that this could be a bit of a tricky spot for the Cards with the Mets having a big time starting pitching edge in this one in my opinion as Clay Holmes started hot but ran out of gas as last year was his first season as a full fledged starter in his career but should now be more comfortable this time around and I think he gets it done here and the Mets start the series with the win.

Chris Ruffolo's Pick: New York Mets -145

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