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Minnesota Twins vs Washington Nationals Prediction 07/25/2025 Picks

Jul 15, 2025; Cumberland, Georgia, USA; American League outfielder Byron Buxton (25) of the Minnesota Twins slides into second base after hitting a double during the ninth inning during the 2025 MLB All Star Game at Truist Park. Mandatory Credit: Dale Zanine-Imagn Images

Jul 15, 2025; Cumberland, Georgia, USA; American League outfielder Byron Buxton (25) of the Minnesota Twins slides into second base after hitting a double during the ninth inning during the 2025 MLB All Star Game at Truist Park. Mandatory Credit: Dale Zanine-Imagn Images

Washington (41-61) vs Minnesota (49-53)

July 25, 2025 at 08:10 PM EDT

The Line: Betting Odds: Minnesota -137 / Washington -124 — Over/Under: +8.5

(Get latest betting odds)

The Washington Nationals are visiting the Minnesota Twins on Friday, July 25th at the Target Field in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Washington Nationals vs Minnesota Twins Prediction. We will examine:

The Minnesota Twins recent form and player performance

The Washington Nationals recent form and player performance

Recent betting trends and streaks involving the Minnesota Twins

Recent betting trends and streaks involving the Washington Nationals

Recent betting trends in games played between the Washington Nationals vs Minnesota Twins

A summary that ties it all together and produces a favorable betting outcome for the Washington Nationals vs Minnesota Twins game

Minnesota Twins Preview

The Minnesota Twinshave a 49-53 record this season and are sitting on the third place of the AL Central. The Twins have a 28-20 home record and are 42-53 in over/under. They are coming off a 3-4 road defeat by the Dodgers, and are 2-5 in their last 7 games. Under is 7-3 in their last 10 games and are playing the Red Sox and the Guardians next.

The Twins have a .241 batting average this season, .312 OBP and .401 Slugging percentage. Minnesota’s pitching staff has a 4.17 ERA and 1.26 WHIP. Byron Buxton leads the Twins with 92 hits, adding a team-high 58 RBI, 23 home runs, and he is the team’s best hitter with a .287 batting average.

Zebby Matthews (R) is the projected starting pitcher for the Twins, and he has a 1-2 record, 6.26 ERA and 1.61 WHIP.

Washington Nationals Preview

The Washington Nationals have a 41-61 record this season and are sitting on the last place of the NL East. The Nationals have a 20-30 road record and are 53-45 in over/under. They are coming off a 0-5 home defeat by the Reds, which snapped their previous two-game winning streak. Over is 6-3 in their last 9 games, and are playing the Astros and the Brewers next.

The Nationals have a .245 batting average this season, .311 OBP and .389 Slugging percentage. Washington’s pitching staff has a 5.20 ERA and 1.41 WHIP. James Wood leads the Nationals with 103 hits, adding 70 RBI and a team-high 24 home runs. CJ Abrams is the team’s best hitter with a .276 batting average.

MacKenzie Gore (L) will take the mound for the Nationals, and he has a 4-9 record, 3.59 ERA and 1.27 WHIP.

Why the Minnesota Twins will win

  • The Nationals have lost 11 of their last 12 games against teams that held a losing record.
  • The Twins have won each of their last four games at Target Field following a loss.
  • The Nationals have failed to cover the run line each of their last 12 games against teams that held a losing record.
  • The Twins have covered the run line in three of their last four games.
  • The Nationals have trailed after 5 innings in seven of their last eight night games against AL Central opponents that held a losing record.
  • The Nationals have trailed after 3 innings in nine of their last 10 games as underdogs against American League opponents.

Why the Washington Nationals will win

  • The Nationals have won four of their last five games as road underdogs against American League opponents following a loss.
  • The Twins have lost five of their last six games as home favorites against National League opponents following a road loss.
  • The Twins have failed to cover the run line in each of their last six games as favorites against NL East opponents.
  • The Nationals have covered the run line in each of their last six games against the Twins following a loss.
  • The Twins have trailed after 3 innings in five of their last six games as home favorites against NL East opponents.
  • The Nationals have led after 5 innings in each of their last three night games.

Total Runs Facts

  • Each of the Nationals’ last nine games against American League opponents have gone OVER the total runs line.
  • Each of the Twins’ last five games as favorites against NL East opponents have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last four home games.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Nationals’ last seven games against American League opponents.

Matchup/League Facts

  • The Twins rank 1st in the league for walks allowed this season (265).
  • The Twins rank 25th in the league for steals this season (53).
  • The Nationals rank 28th in the league for ERA this season (5.20).
  • The Nationals rank 28th in the league for opponent batting average this season (.265).

Washington Nationals vs Minnesota Twins Prediction

The Nationals are 6-3 in their last 9 meetings against the Twins, and are 4-1 in their last 5 visits in Minnesota. Under is 4-2 in their last 6 meetings in Minnesota.  

In this Washington Nationals vs Minnesota Twins Prediction, the Twins are coming as home favorites. The Twins are rightfully favored, as theyhave a better overall record, and have been very strong at home, while the Nats are struggling on the road. I don’t trust either pitcher in this matchup, as they are both in terrible form lately, with a combined 12.30 ERA in their last 5 starts. The Nationals have the worst bullpen in the league, while the Twins have the 8th-worst, and the Nationals are better against righties. I expect a lot of runs in this game, so take the over 8 runs.

Nikos Lagouretos's Pick: Over 8

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