Minnesota Twins vs San Francisco Giants Prediction 9/22/2026 Today’s MLB Picks
Chris Ruffolo
Aug 26, 2026; West Sacramento, California, USA; Minnesota Twins center fielder Luke Keaschall (15) catches a fly ball against the Athletics during the first inning at Sutter Health Park. Mandatory Credit: Dennis Lee-Imagn Images
MATCHUP
Minnesota Twins
San Francisco Giants
Team Records
73-84
65-92
Spread
-1.5 129
+1.5 -156
Moneyline
-135
+112
Total
Over 7.5 (-105)
Under 7.5 (-115)
Where
Oracle Park, San Francisco, California
When
Tuesday, September 22, 2026
Time
09:45 PM EDT
TV
MLB.TV
The Minnesota Twins and the San Francisco Giants meet Tuesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. San Francisco Giants prediction.
Starting Pitching Matchup
The Minnesota Twins will send out Taj Bradley for the start here and Bradley is 11-6 with a 3.81 ERA and 199 strikeouts this season. Anthony Molina will start for the Giants and is 3-1 with a 4.18 ERA and 25 strikeouts this season.
Minnesota Twins Recap
The Minnesota Twins come into this game looking to rebound from a 5-2 loss at the hands of the Giants on Monday to fall to 73-84 this season. After this series, the Twins will head home for a set against the Texas Rangers.
Twins Alternate Wins & Losses In 7 Straight
Brooks Lee leads the Twins with a team-high 143 hits while adding 24 doubles, 3 triples, 24 home runs, and 82 RBIs so far this season. Josh Bell leads Minnesota with a team-high 91 RBIs alongside 142 hits, 28 doubles, a triple, and 20 home runs on the year. Luke Keaschall has contributed 141 hits with 26 doubles, a triple, 9 home runs, and 46 RBIs, while Kody Clemens leads the Twins with a team-high 26 home runs along with 121 hits, 22 doubles, 7 triples, and 76 RBIs. Byron Buxton has added 94 hits with 18 doubles, a triple, 25 home runs, and 46 RBIs, and Victor Caratini has chipped in 71 hits with 9 doubles, 7 home runs, and 44 RBIs up to this point in the season.
San Francisco Giants Recap
The San Francisco Giants come into this game looking to add on to their win over the Twins from Monday to sit at 65-92 this season. After this series, the Giants will take on the Los Angeles Dodgers in a series at home.
Giants Snap Three-Game Slide
Jung Hoo Lee leads the Giants with a team-high 149 hits while adding 31 doubles, 4 triples, 10 home runs, and 57 RBIs so far this season. Rafael Devers paces San Francisco across the board in power, leading the team with 37 home runs and 98 RBIs alongside 144 hits, 36 doubles, and a triple on the year. Willy Adames has contributed 107 hits with 25 doubles, a triple, 21 home runs, and 51 RBIs while logging 139 strikeouts. Matt Chapman has logged 72 hits with 18 doubles, a triple, 7 home runs, and 42 RBIs for San Francisco up to this point in the season.
Minnesota Twins @ San Francisco Giants Betting Trends: September 22, 2026
Probable Starting Pitcher: Anthony Molina Record this season: 3-1 ERA: 4.18
Home Record: 1-1
Last 5 against Twins: 0-0
Why the San Francisco Giants will win
The Twins have lost each of their last six road games against NL opponents.
The home team has won seven of the last eight games between the Twins and Giants.
The Twins have failed to cover the run line each of their last eight night games against NL West opponents that held a losing record.
The underdogs have covered the run line in each of the last seven games between the Twins and Giants.
The Giants have won the first inning in eight of their last nine night games at Oracle Park.
The Giants have led after 3 innings in five of their last six games.
The Giants have led after 5 innings in seven of their last eight home games against opponents that held a losing record.
Probable Starting Pitcher: Taj Bradley Record this season: 11-6 ERA: 3.81
Road Record: 7-4
Last 5 against Giants: –
Why the Minnesota Twins will win
The Giants have lost seven of their last eight games against AL Central opponents following a win.
The Twins have won four of their last five road games following a loss.
The Giants have failed to cover the run line in seven of their last eight games against AL Central opponents following a win.
The Twins have covered the run line in each of their last five road games following a loss.
The Twins have led after 3 innings in three of their last four games.
The Giants have trailed after 5 innings in four of their last five home games.
Total Runs Facts
Fifteen of the Giants’ last 17 night games against AL Central opponents have gone UNDER the total runs line.
Each of the Twins’ last three games as favorites against NL opponents have gone UNDER the total runs line.
There has been at least one run scored in the first inning in each of the Giants’ last nine night games at Oracle Park.
There has been at least one run scored in the first inning in each of the Twins’ last six games as favorites against NL opponents.
San Francisco Giants Player Prop Facts
Drew Gilbert has hit a home run in each of the Giants’ last two games against opponents that held a losing record.
Anthony Molina has recorded four or more strikeouts in each of his last four appearances.
Bryce Eldridge has recorded at least one hit in each of his last 14 appearances in night games.
Minnesota Twins Player Prop Facts
Brooks Lee has hit a home run in four of the Twins’ last five road games against NL opponents.
Taj Bradley has recorded seven or more strikeouts in each of his last six appearances in night games against teams that held a losing record.
Josh Bell has recorded at least one hit in each of his last eight appearances with the Twins as road favorites.
Taj Bradley ranks 9th in the league for total Strikeouts (199) this season.
Matchup/League Facts
The Giants rank 30th in the league for walks this season (437).
The Giants rank 28th in the league for on-base percentage this season (.308).
The Twins rank 26th in the league for runs allowed this season (781).
The Twins rank 25th in the league for walks this season (493).
Minnesota Twins vs. San Francisco Giants Prediction
I’m on the Twins in this one. I get the case to be made for the Giants after they looked solid in Monday’s opener, but I think the Twins get a far better matchup on the mound here with Bradley going as Bradley’s been one of the more profitable options on the bump for Minnesota this season. Molina is a fairly new commodity for the Giants, and I think this could just be a bad spot for San Francisco. Give me the Twins.
