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Minnesota Twins vs San Diego Padres Prediction 8/22/2026 Today’s MLB Picks

Aug 21, 2026; San Diego, California, USA;  San Diego Padres center fielder Jackson Merrill (3) celebrates with shortstop Xander Bogaerts (2) after defeating the Minnesota Twins at Petco Park.  Mandatory Credit: David Frerker-Imagn Images

Aug 21, 2026; San Diego, California, USA; San Diego Padres center fielder Jackson Merrill (3) celebrates with shortstop Xander Bogaerts (2) after defeating the Minnesota Twins at Petco Park. Mandatory Credit: David Frerker-Imagn Images

MATCHUP Minnesota Twins San Diego Padres
Team Records 63-66 69-60
Spread +1.5 -163 -1.5 135
Moneyline +135 -163
Total Over 8.5 (-106) Under 8.5 (-114)
Where Petco Park, San Diego, California
When Saturday, August 22, 2026
Time 08:40 PM EDT
TV MLB.TV
The Minnesota Twins and San Diego Padres meet Saturday in MLB action at Petco Park. Here’s a Minnesota Twins vs San Diego Padres Prediction. This article will include a Minnesota Twins vs San Diego Padres Pick.

Minnesota Twins Betting Preview


The Minnesota Twins are 63-66 on the year and play the Athletics and White Sox next. The Minnesota Twins are batting .246 on the season, with a .321 OBP and a .406 slugging percentage. The Minnesota Twins’ pitching staff has a 4.62 ERA and a 1.38 WHIP. Josh Bell leads the Minnesota Twins with 117 hits and 77 RBI, while Luke Keaschall and Brooks Lee have combined for 219 hits and 103 RBI.

Dean Kremer gets the ball for the Minnesota Twins, and he is 2-4 with a 5.40 ERA and 53 strikeouts this season. Kremer is 0-2 with a 3.00 ERA and 11 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview


The San Diego Padres are 69-60 on the year and play the Pirates and Rays next. The San Diego Padres are batting .238 on the season, have a .315 OBP, and have a .389 slugging percentage. The San Diego Padres’ pitching staff has a 4.05 ERA and a 1.31 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 137 hits and 61 RBI, while Jackson Merrill and Manny Machado have combined for 216 hits and 134 RBI.

Casey Mize gets the ball for the San Diego Padres, and he is 5-7 with a 3.18 ERA and 95 strikeouts this season. Mize is 4-5 with a 5.34 ERA and 53 strikeouts in his career against the Minnesota Twins.

Why the San Diego Padres will win

Why the Minnesota Twins will win

Total Runs Facts

San Diego Padres Player Prop Facts

Minnesota Twins Player Prop Facts

Matchup/League Facts

Minnesota Twins vs San Diego Padres Prediction


The Twins have issues stringing wins together, and Kremer isn’t a pitcher to run to the window to back. Kremer has a 5.40 ERA and 1.18 WHIP, while Mize has a 3.18 ERA and 1.07 WHIP. Mize has settled down in his last two starts, allowing 8 hits and 2 runs in his last 12 innings. I’m going to roll with the Padres on Saturday night.

Randy Chambers's Pick: San Diego Padres

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