Minnesota Twins vs Los Angeles Angels Prediction 9/9/2025 Today’s MLB Picks

In this article, we will formulate a Twins vs Angels Prediction for this MLB game on Tuesday, September 9th at the Angel Stadium in the second game of this series, with the Twins having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 67-77 record this season and are sitting on the 4th place of the AL West. The Angels have a 35-38 home record and 78-63 in over/under They are coming off a 3-12 home defeat by the Twins, and are 1-4 in their last 5 games. Over is 3-1 in their last 4 games and are playing the Mariners and the Brewers next.

The Angels have a .227 batting average this season, .303 OBP and .399 Slugging percentage. LA’s pitching staff has a 4.84 ERA and 1.44 WHIP. Zach Neto leads the Angels with 126 hits, while Nolan Schanuel is the team’s best hitter with a .266 batting average. Taylor Ward leads the team with 95 RBI, while Jo Adell adds a team-high 35 home runs.

Kyle Hendricks (R) is the projected starting pitcher for the Angels, and he has a 6-9 record, 4.81 ERA and 1.30 WHIP.

Minnesota Twins Preview

The Minnesota Twins have a 64-80 record this season and are sitting on the 4th place of the AL Central. The Twins have a 29-44 road record and are 68-67 in over/under. They are coming off a 12-3 road victory over the Angels, and have back-to-back wins. Over is 8-3 in their last 11 games and are playing the Yankees and the Diamondbacks next.

The Twins have a .239 batting average this season, .312 OBP and .398 Slugging percentage. Minnesota’s pitching staff has a 4.55 ERA and 1.33 WHIP. Trevor Larnach leads the Twins with 117 hits, while Byron Buxton adds team-highs both in RBI, with 74, and in home runs, with 30. He is also the team’s best hitter with a .271 batting average.

Zebby Matthews (R) is the projected starter for the Twins, and he has a 4-4 record, 4.73 ERA and 1.42 WHIP.

Minnesota Twins @ Los Angeles Angels Betting Trends: September 9, 2025

• Probable Starting Pitcher: Kyle Hendricks      Record this season: 6-9      ERA: 4.81
• Home Record: 4-5
• Last 5 against Twins: 1-4

Why the Los Angeles Angels will win

• The Twins have lost each of their last seven games as favorites against American League opponents.
• The underdogs have won seven of the Twins’ last eight games.
• The Angels have covered the run line in each of their last 11 games as home underdogs against American League opponents following a loss.
• The Twins have failed to cover the run line in each of their last seven games as favorites against American League opponents.
• The Twins have lost the first inning in three of their last four games as road favorites.
• The Twins have trailed after 3 innings in each of their last seven games as road favorites against American League opponents.
• The Angels have led after 5 innings in each of their last seven Tuesday games against the Twins at Angel Stadium of Anaheim.

• Probable Starting Pitcher: Zebby Matthews      Record this season: 4-4      ERA: 4.73
• Road Record: 2-3
• Last 5 against Angels: 0-0

Why the Minnesota Twins will win

• The Twins have won each of their last seven games against the Angels following a win.
• The Angels have lost each of their last seven night games against teams that held a losing record.
• The Angels have failed to cover the run line each of their last seven night games against teams that held a losing record.
• The Twins have covered the run line in each of their last seven games against the Angels following a win.
• The Angels have trailed after 3 innings in six of their last seven games as underdogs against AL Central opponents.
• The Angels have trailed after 5 innings in each of their last seven games against AL Central opponents that held a losing record.
• The Twins have won the first inning in each of their last three games as favorites against the Angels.

Total Runs Facts

• Seven of the Angels’ last eight games as underdogs have gone UNDER the total runs line.
• Ten of the Twins’ last 12 night games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last 10 games against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Angels’ last 10 games as home underdogs.

Los Angeles Angels Player Prop Facts

• Jo Adell has hit a home run in four of the Angels’ last five games as underdogs.
• Jo Adell has recorded at least one hit in each of the Angels’ last eight games as home underdogs.
• Jo Adell ranks 8th in the league in Home Runs (35) this season.

Minnesota Twins Player Prop Facts

• Trevor Larnach has recorded at least one hit in each of his last eight appearances against the Angels.
• Ryan Jeffers has hit a home run in three of his last five road appearances against AL West opponents that held a losing record.
• Byron Buxton ranks 4th amongst qualified players for Slugging Percentage (.562) this season.

Matchup/League Facts

• The Angels rank 30th in the league for strikeouts against this season (1422).
• The Angels rank 30th in the league for walks allowed this season (553).
• The Twins rank 4th in the league for walks allowed this season (410).
• The Twins rank 26th in the league for opponent batting average this season (.259).

Twins vs Angels Prediction

The Twins are 10-1 in their last 11 head-to-head meetings against the Angels, and have won their last 4 visits in Los Angeles. Over is 7-3-1 in their last 11 meetings.

In this Twins vs Angels Prediction, the Twins are coming as -120 road favorites. I don’t trust either pitcher in this matchup, as they both have an ERA close to 5.00. Matthews has been terrible on the road for the Twins, with a 5.77 ERA, while Hendricks is coming into this matchup in poor form for the Angels, with a 5.61 ERA across his last five starts. Hendricks has torched in his previous start against the Twins this season, having given up 7 runs in just 3 innings of work. The opening game of this series had 15 total runs, and I expect another high-scoring affair today. Take the over 9 runs in this one.