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Minnesota Twins vs Los Angeles Angels Prediction 9/10/2025 Today’s MLB Picks

Sep 7, 2025; Anaheim, California, USA; Los Angeles Angels designated hitter Mike Trout (27) runs after hitting a double against the Athletics during the third inning at Angel Stadium. Mandatory Credit: William Liang-Imagn Images

Sep 7, 2025; Anaheim, California, USA; Los Angeles Angels designated hitter Mike Trout (27) runs after hitting a double against the Athletics during the third inning at Angel Stadium. Mandatory Credit: William Liang-Imagn Images

Minnesota (64-81) vs Los Angeles (68-77)

September 10, 2025 at 04:07 PM EDT

The Line: Betting Odds: Los Angeles -135 — Over/Under: +9

(Get latest betting odds)

The Minnesota Twins and the Los Angeles Angels meet Wednesday in MLB action from Angel Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Los Angeles Angels prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Taj Bradley for the start here and Bradley is 6-7 with a 4.92 ERA and 109 strikeouts this season. This will be Bradley’s second career start against the Angels. Jose Soriano will get the start for the Angels and is 10-10 with a 4.07 ERA and 148 strikeouts this season. In his career, Soriano is 0-2 with a 9.45 ERA and 5 strikeouts against the Twins.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to shake off their 12-2 loss at the hands of the Angels on Tuesday to sit at 64-81 this season. After this series, the Twins will head home for a series against the Arizona Diamondbacks.

Twins Looking To Win Rubber Match

Byron Buxton has 116 hits along with 18 doubles, a team-high 30 home runs and 74 RBIs with 22 stolen bases and 7 triples while Trevor Larnach’s chipped in 117 hits with 20 doubles, 16 home runs and 57 RBIs as well this season. Brooks Lee has contributed 104 hits with 14 doubles, 14 home runs and 57 RBIs and Matt Wallner has 21 homers and 39 RBIs as well. 

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to add on to their win over the Twins to sit at 68-77 this season. After this series, the Angels will head on the road for a series against the Seattle Mariners.

Angels Alternate Wins & Losses In 4 Straight Games

Logan O’Hoppe has 85 hits including 19 home runs and 43 RBIs while Nolan Schanuel has 123 hits with 22 doubles, a triple, 10 home runs and 49 RBIs. Luis Rengifo has 15 doubles with his 113 hits and Taylor Ward also has 117 hits as well while Mike Trout’s added 20 home runs and 55 RBIs so far this season. Jo Adell has 35 home runs and 94 RBIs. Ward has also chipped in 30 doubles, 30 home runs and 96 RBIs but has a team-high 156 strikeouts while Zach Neto has 29 doubles, 25 home runs, 60 RBIs and 25 stolen bases.

Minnesota Twins @ Los Angeles Angels Betting Trends: September 10, 2025

  • Probable Starting Pitcher: Jose Soriano      Record this season: 10-10      ERA: 4.07
  • Home Record: 2-8
  • Last 5 against Twins: 0-2

Why the Los Angeles Angels will win

  • The Twins have lost seven of their last eight day games against AL West opponents.
  • The home team has won six of the last seven games between the Twins and Angels.
  • The Twins have failed to cover the run line in seven of their last eight games against teams that held a losing record.
  • The Angels have covered the run line each of their last five day games against American League opponents that held a losing record.
  • The Twins have trailed after 5 innings in five of their last six day games against American League opponents that held a losing record.
  • The Twins have trailed after 3 innings in five of their last six road games against American League opponents that held a losing record.
  • Probable Starting Pitcher: Taj Bradley      Record this season: 6-7      ERA: 4.92
  • Road Record: 2-4
  • Last 5 against Angels: 0-0

Why the Minnesota Twins will win

  • The underdogs have won eight of the Twins’ last nine games.
  • The Angels have lost each of their last five games as favorites against American League opponents.
  • The Twins have covered the run line in each of their last 10 games as road underdogs against AL West opponents following a loss.
  • The Angels have failed to cover the run line in 12 of their last 13 games as home favorites against AL Central opponents following a win.
  • The Angels have lost the first inning in each of their last four day games against AL Central opponents that held a losing record.
  • The Angels have trailed after 3 innings in each of their last six Wednesday games as favorites.
  • The Angels have trailed after 5 innings in 12 of their last 13 games as home favorites against AL Central opponents.

Total Runs Facts

  • Each of the Angels’ last five games as favorites against American League opponents have gone OVER the total runs line.
  • Each of the Twins’ last four games as underdogs against AL West opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last six games as underdogs against AL West opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last seven Wednesday day games.

Los Angeles Angels Player Prop Facts

  • Mike Trout has recorded at least one hit in each of his last 12 Wednesday day appearances.
  • Jo Adell has hit a home run in four of his last five appearances against opponents that held a losing record.

Minnesota Twins Player Prop Facts

  • Trevor Larnach has recorded a Double in three of his last four appearances in day games.
  • Trevor Larnach has recorded at least one hit in each of his last eight appearances with the Twins as underdogs against AL West opponents.
  • James Outman has hit a home run in each of his last two appearances with his team as a road underdog against AL West opponents.
  • Byron Buxton ranks 4th amongst qualified players for Slugging Percentage (.563) this season.

Matchup/League Facts

  • The Angels rank 30th in the league for strikeouts against this season (1429).
  • The Angels rank 30th in the league for walks allowed this season (554).
  • The Twins rank 5th in the league for walks allowed this season (413).
  • The Twins rank 26th in the league for opponent batting average this season (.260).

Minnesota Twins vs. Los Angeles Angels Prediction

I’m on the over in this one. Jose Soriano has really been struggling at home in a lot of his recent outings at Angel Stadium while Taj Bradley has been in and out of rotations this season and frankly has been batting practice for the better part of the last season or so. I think we’re going to get some more runs scored in this game, so give me the over here.

Chris Ruffolo's Pick: Over 9

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