Minnesota Twins vs Chicago White Sox Prediction 8/22/2025 Today’s MLB Picks

Nikos Lagouretos

3 months ago

Apr 24, 2025; Minneapolis, Minnesota, USA; Minnesota Twins third baseman Brooks Lee (2) singles against the Chicago White Sox in the fifth inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

MATCHUP	Minnesota Twins	Chicago White Sox
Team Records	58-69	45-82
Where	Rate Field, Chicago, Illinois
When	Friday, August 22, 2025
Time	07:40 PM EDT
TV	CHSN

In this article, we will formulate a Twins vs White Sox Prediction for this MLB game on Friday, August 22nd at the Rate Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 45-82 record this season and are sitting on the last place of the AL Central. The White Sox have a 26-36 home record and are 57-62 in over/under. They are coming off a 0-1 road defeat by the Braves, and are 1-6 in their last 7 games. Under is 5-2 in their last 7 games and are playing the Royals and the Yankees next.

The White Sox have a .231 batting average this season, .301 OBP and .370 Slugging percentage. Chicago’s pitching staff has a 4.18 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 108 hits, and he is the team’s best hitter with a .271 batting average. He also leads the team in RBI with 55, adding a team-high 17 home runs.

Aaron Civale (R) is the projected starting pitcher for the White Sox, and he has a 3-8 record, 4.88 ERA and 1.35 WHIP.

Minnesota Twins Preview

The Minnesota Twins have a 58-69 record this season and are sitting on the 4th place of the AL Central. The Twins have a 25-38 road record and are 55-63 in over/under. They are coming off a 3-8 home defeat by the Athletics, and are 2-8 in their last 10 games. Over is 3-1-1 in their last 5 games and are playing the Blue Jays and the Padres next.

The Twins have a .237 batting average this season, .309 OBP and .395 Slugging percentage. Minnesota’s pitching staff has a 4.25 ERA and 1.28 WHIP. Byron Buxton leads the Twins with 99 hits, leading the team both in RBI, with 61, and in home runs, with 25. He is also the team’s best hitter with a .270 batting average.

Zebby Matthews (R) is the projected starting pitcher for the Twins, and he has a 3-4 record, 5.06 ERA and 1.44 WHIP.
Twins vs White Sox Prediction

The Twins are 8-2 in their last 10 meetings against the White Sox, and are 3-1 in their last 4 visits in Chicago. Over is 5-2-2 in their last 9 meetings.

Why the Chicago White Sox will win

The Twins have lost seven of their last eight games as favorites after playing the previous day.
The underdogs have won four of the Twins’ last five games.
The Twins have failed to cover the run line in 10 of their last 11 night games against teams that held a losing record.
The White Sox have covered the run line in nine of their last 10 night games against teams that held a losing record.
The Twins have trailed after 3 innings in eight of their last nine night games against American League opponents.
The White Sox have led after 5 innings in four of their last five games against the Twins at Rate Field.

Why the Minnesota Twins will win

The White Sox have lost each of their last 11 night games against AL Central opponents following a road loss.
The Twins have won eight of their last nine games against the White Sox following a loss.
The Twins have covered the run line in seven of their last eight road games following a loss.
The White Sox have failed to cover the run line in seven of their last eight games against the Twins following a road loss.
The White Sox have trailed after 3 innings in four of their last five night games against AL Central opponents that held a losing record.
The Twins have won the first inning in each of their last four road games against AL Central opponents.
The Twins have led after 5 innings in each of their last seven Friday games against AL Central opponents that held a losing record.

Total Runs Facts

Each of the Twins’ last five road games against AL Central opponents have gone OVER the total runs line.
Each of the White Sox’s last four games against AL Central opponents have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last four games.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last four night games between the Twins and White Sox.

Matchup/League Facts

The White Sox rank 29th in the league for hits this season (969).
The White Sox rank 29th in the league for RBIs this season (473).
The Twins rank 3rd in the league for walks allowed this season (347).
The Twins rank 25th in the league for steals this season (63).

Twins vs White Sox Prediction

In this Twins vs White Sox Prediction, the Twins are coming as -142 road favorites. There is no way I’m laying this kind of juice on the road with Zebby Matthews on the mound, who has been terrible on the road, with a 5.46 road ERA. Civale has had two rough outings, but he had three straight shutouts before that. On top of that. Chicago has a better bullpen to back Civale up, and with both teams struggling I will side with the home team and the plus money. Take the White Sox on the moneyline in this one.