Minnesota Twins vs Baltimore Orioles Prediction 3/26/2026 Today’s MLB Picks

The Minnesota Twins and the Baltimore Orioles meet Thursday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Baltimore Orioles prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Joe Ryan for the start and Ryan was 13-10 with a 3.42 ERA and 194 strikeouts last season. Baltimore will send out Trevor Rogers for the start here and Rogers was 9-3 with a 1.81 ERA and 103 strikeouts last season.

Minnesota Twins Recap

The Minnesota Twins come into the 2026 season looking to turn the page after a dismal 2025 campaign that saw them finish 70-92, landing fourth in the AL Central. It was a year defined by a massive trade deadline sell-off and inconsistent play, though Byron Buxton finally provided a silver lining by staying relatively healthy and putting up a career-high 35 home runs. The core of Buxton, Royce Lewis, and Carlos Correa still gives the Twins plenty of optimism if they can stay on the field, but the rotation is already facing adversity with Pablo Lopez slated to miss the year with an injury. Only time will tell if Minnesota can reverse course and get back to prominence in the AL Central

Baltimore Orioles Recap

The Baltimore Orioles come into the 2026 campaign looking to turn the page after a brutal 2025 campaign that saw them finish in the AL East cellar with a 75-87 record. After high expectations, the season spiraled early with the firing of Brandon Hyde in May, and while the team showed life under interim manager Tony Mansolino, they never recovered from a mid-season stretch where they lived in last place for five straight months. The young core remains centered around Gunnar Henderson and Jackson Holliday, but health is already the story of the spring as Holliday is slated to miss time with a fractured hamate bone and Jordan Westburg is out until at least May with a partial UCL tear. The Orioles made a splash in free agency by winning one of the prizes in Pete Alonso, but it’ll be interesting to see if the Orioles can get back on track in the toughest division in baseball.

Minnesota Twins @ Baltimore Orioles Betting Trends: March 26, 2026

• Probable Starting Pitcher: Trevor Rogers      Record this season: –      ERA: –
• Home Record: –
• Last 5 against Twins: –

Why the Baltimore Orioles will win

• The Twins have lost each of their last seven day games following an extra innings loss.
• The Orioles have won each of their last five day games against AL Central opponents.
• The Orioles have covered the run line in each of their last five season openers.
• The Twins have failed to cover the run line in each of their last four games after going to extra innings.
• The Orioles have led after 5 innings in each of their last five home openers.
• The Orioles have won the first inning in three of their last four day games against AL Central opponents.
• The Orioles have led after 3 innings in each of their last four home openers.

• Probable Starting Pitcher: Joe Ryan      Record this season: –      ERA: –
• Road Record: –
• Last 5 against Orioles: 0-1

Why the Minnesota Twins will win

• The Twins have won each of their last six games against the Orioles.
• The Orioles have lost five of their last six games as home favorites against American League opponents.
• The Orioles have failed to cover the run line in each of their last 10 games as home favorites.
• The Twins have covered the run line in each of their last six games against the Orioles.
• The Orioles have lost the first inning in four of their last five games.
• The Orioles have trailed after 3 innings in each of their last five games.
• The Orioles have trailed after 5 innings in four of their last five games.

Total Runs Facts

• Each of the Twins’ last nine games have gone UNDER the total runs line.
• Each of the Orioles’ last six day games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last nine games as favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Twins’ last nine games against American League opponents.

Baltimore Orioles Player Prop Facts

• Pete Alonso has recorded a Double in three of his last four appearances.
• Tyler O’Neill has hit a home run in each of his last six appearances in season openers.
• Trevor Rogers has recorded five or more strikeouts in each of his last six home appearances.
• Ryan Mountcastle has recorded at least one hit in each of his last 17 appearances against the Twins.
• Trevor Rogers has recorded a win in four of his last five appearances in day games.
• Pete Alonso ranked 8th in the league in Home Runs (38) last season.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in four of his last five appearances with the Twins as road underdogs against AL opponents.
• Joe Ryan has recorded seven or more strikeouts in each of his last four appearances with the Twins as underdogs against AL East opponents.
• Josh Bell has recorded at least one hit in each of his last 12 appearances against AL East opponents.
• Byron Buxton ranked 6th amongst qualified players for Slugging Percentage (.551) last season.

Matchup/League Facts

• The Orioles ranked 27th in the league for strikeouts against last season (1457).
• The Orioles ranked 27th in the league for home runs allowed last season (217).
• The Twins ranked 4th in the league for walks allowed last season (459).
• The Twins ranked 25th in the league for opponent batting average last season (.256).

Minnesota Twins vs. Baltimore Orioles Prediction

I’m on the Orioles here. I just think that Baltimore is the team with more upside coming into the season, and I like the matchup here for Baltimore against Joe Ryan a lot more than Minnesota’s matchup with Trevor Rogers. Should be a fun series, but I’m rolling with Baltimore here.

Chris Ruffolo's Pick: Baltimore -145