Milwaukee (94-60) vs St. Louis (75-79)
September 20, 2025 at 07:15 PM EDT
The Line: Betting Odds: St. Louis +1.5 — Over/Under: +9
The Milwaukee Brewers and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Milwaukee Brewers vs St. Louis Cardinals Prediction. This article will include a Milwaukee Brewers vs St. Louis Cardinals Pick.
The Milwaukee Brewers are 94-60 on the year and play the Padres and Reds next. The Milwaukee Brewers are batting .261 on the season, have a .334 OBP, and a .409 slugging percentage. The Milwaukee Brewers pitching staff has a 3.62 ERA and a 1.23 WHIP. Brice Turang leads the Milwaukee Brewers with 160 hits and 76 RBI, while Sal Frelick and Christian Yelich have combined for 294 hits and 162 RBI.
Chad Patrick gets the ball for the Milwaukee Brewers, and he is 3-8 with a 3.64 ERA and 116 strikeouts this season. Patrick is 0-1 with a 3.38 ERA and 3 strikeouts in his career against the St. Louis Cardinals.
The St. Louis Cardinals are 75-79 on the year and play the Giants and Cubs next. The St. Louis Cardinals are batting .246 on the season, have a .315 OBP, and a .379 slugging percentage. The St. Louis Cardinals pitching staff has a 4.27 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 136 hits and 66 RBI, while Willson Contreras and Brendan Donovan have combined for 252 hits and 127 RBI.
Miles Mikolas gets the ball for the St. Louis Cardinals, and he is 8-10 with a 4.80 ERA and 93 strikeouts this season. Mikolas is 11-7 with a 3.82 ERA and 109 strikeouts in his career against the Milwaukee Brewers.
The Cardinals are all but out of the playoff race and while Mikolas has been solid lately, he’s been hittable overall with his 4.80 ERA and 1.31 WHIP. Patrick is having a decent rookie season with a 3.64 ERA and 1.28 WHIP, and the Brewers are a few more wins away from locking up the best record and home field throughout the playoffs. Have to take advantage against non-playoff teams. Give me the Brewers.
Milwaukee Brewers Betting Preview
The Milwaukee Brewers are 94-60 on the year and play the Padres and Reds next. The Milwaukee Brewers are batting .261 on the season, have a .334 OBP, and a .409 slugging percentage. The Milwaukee Brewers pitching staff has a 3.62 ERA and a 1.23 WHIP. Brice Turang leads the Milwaukee Brewers with 160 hits and 76 RBI, while Sal Frelick and Christian Yelich have combined for 294 hits and 162 RBI.
Chad Patrick gets the ball for the Milwaukee Brewers, and he is 3-8 with a 3.64 ERA and 116 strikeouts this season. Patrick is 0-1 with a 3.38 ERA and 3 strikeouts in his career against the St. Louis Cardinals.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 75-79 on the year and play the Giants and Cubs next. The St. Louis Cardinals are batting .246 on the season, have a .315 OBP, and a .379 slugging percentage. The St. Louis Cardinals pitching staff has a 4.27 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 136 hits and 66 RBI, while Willson Contreras and Brendan Donovan have combined for 252 hits and 127 RBI.
Miles Mikolas gets the ball for the St. Louis Cardinals, and he is 8-10 with a 4.80 ERA and 93 strikeouts this season. Mikolas is 11-7 with a 3.82 ERA and 109 strikeouts in his career against the Milwaukee Brewers.
Milwaukee Brewers @ St. Louis Cardinals Betting Trends: September 20, 2025
- Probable Starting Pitcher: Miles Mikolas Record this season: 8-10 ERA: 4.80
- Home Record: 4-4
- Last 5 against Brewers: 2-2
Why the St. Louis Cardinals will win
- The Brewers have lost each of their last four games as road favorites after playing the previous day.
- The underdogs have won eight of the Cardinals’ last 10 games at Busch Stadium.
- The underdogs have covered the run line in seven of the last eight games between the Brewers and Cardinals.
- The Brewers have failed to cover the run line in eight of their last nine games as favorites following a road loss.
- The Brewers have trailed after 3 innings in each of their last three games as road favorites.
- The Cardinals have led after 5 innings in four of their last five games as underdogs.
- Probable Starting Pitcher: Chad Patrick Record this season: 3-8 ERA: 3.64
- Road Record: 1-4
- Last 5 against Cardinals: 0-1
Why the Milwaukee Brewers will win
- The Brewers have won 10 of their last 11 road games against teams that held a losing record.
- The Cardinals have lost each of their last four home games against NL Central opponents following a home win.
- The Cardinals have failed to cover the run line in each of their last eight home games against National League opponents following a win.
- The Brewers have covered the run line in 10 of their last 11 road games against National League opponents that held a losing record.
Total Runs Facts
- Five of the Cardinals’ last six games as home underdogs have gone UNDER the total runs line.
- Four of the Brewers’ last five games as road favorites have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Cardinals’ last five games as underdogs.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Brewers’ last eight Saturday night games.
St. Louis Cardinals Player Prop Facts
- Miles Mikolas has recorded three or more strikeouts in each of his last 13 appearances with the Cardinals as underdogs against NL Central opponents.
- Brendan Donovan has recorded at least one hit in each of his last eight appearances with the Cardinals as underdogs against the Brewers.
- Brendan Donovan has recorded a Double in each of the Cardinals’ last three games against the Brewers at Busch Stadium.
- Willson Contreras has hit a home run in four of his last 11 appearances with his team as a home underdog against the Brewers.
Milwaukee Brewers Player Prop Facts
- Sal Frelick has hit a home run in each of his last two appearances with the Brewers as favorites.
- Andrew Vaughn has recorded at least one hit in each of his last nine road appearances against NL opponents that held a losing record.
- Jackson Chourio has recorded a Double in four of the Brewers’ last five games at Busch Stadium.
Milwaukee Brewers vs St. Louis Cardinals Prediction
The Cardinals are all but out of the playoff race and while Mikolas has been solid lately, he’s been hittable overall with his 4.80 ERA and 1.31 WHIP. Patrick is having a decent rookie season with a 3.64 ERA and 1.28 WHIP, and the Brewers are a few more wins away from locking up the best record and home field throughout the playoffs. Have to take advantage against non-playoff teams. Give me the Brewers.