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Milwaukee Brewers vs Pittsburgh Pirates Prediction 5/22/25 MLB Picks

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Pittsburgh Pirates (17-33) vs Milwaukee Brewers (24-26)

Game Info: Thursday, May 22, 2025 at 6:40 pm (PNC Park)

The Line: Betting Odds: Pittsburgh Pirates +105 / Milwaukee Brewers -125 — Over/Under: 8.5

(Get latest betting odds)

The Milwaukee Brewers and the Pittsburgh Pirates meet Thursday in MLB action from PNC Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Milwaukee Brewers vs. Pittsburgh Pirates prediction.

Starting Pitching Matchup

The Milwaukee Brewers did not have a starting pitcher announced at the time that this article was posted. The Pittsburgh Pirates will send out Mike Burrows here for his major league debut.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to bounce back from an 8-4 loss at the hands of the Baltimore Orioles on Wednesday to fall to 24-26 on the year. After this series, the Brewers will head home for an interleague series against the Boston Red Sox.

Brewers Have Three-Game Win Streak Snapped

Brice Turang has 51 hits with 4 home runs, 20 RBIs, and 13 stolen bases, while Jackson Chourio has 51 hits with a team-high 14 doubles, 7 home runs, and 26 RBIs, and Sal Frelick has 44 hits as well as 3 triples and 9 stolen bases so far this season. Christian Yelich also has 8 stolen bases with 7 homers and 26 RBIs while also adding 4 doubles. Yelich also has a team-high 56 strikeouts up to this point in the year. William Contreras has 4 homers and 23 RBIs as well this season. Rhys Hoskins has added 45 hits with 7 home runs, 27 RBIs, and 9 doubles.

Why the Milwaukee Brewers will win

Milwaukee Brewers Player Prop Facts

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to build on their 3-1 win over the Cincinnati Reds from Wednesday’s series finale to fall to 17-33 on the year. After this series, the Pirates will head on the road for a series against the Arizona Diamondbacks.

Pirates Looking To Carry Over Positive Vibes

Bryan Reynolds has 39 hits with 5 doubles, 6 home runs, and 24 RBIs while also leading the Pirates with 59 strikeouts so far this season. Oneil Cruz has posted a team-high 8 home runs and 18 RBIs with 18 stolen bases, while Isiah Kiner-Falefa has 36 hits with 7 stolen bases. Emmanuel Valdez also has a pair of triples this season. Tommy Pham has 4 doubles and Andrew McCutchen has 34 hits with 7 doubles, and KeBryan Hayes has 43 hits with 15 RBIs and 5 stolen bases.

Why the Pittsburgh Pirates will win

Pittsburgh Pirates Player Prop Facts

Total Runs Facts

Milwaukee Brewers vs. Pittsburgh Pirates Prediction

I’m on the Brewers here. It would be nice to know who the Brewers are sending out for this start, but the thing is that I’m not sure it matters with how inconsistent the Pirates continue to be at the plate. The Brewers didn’t have the greatest finish to their series against the slumping Orioles, but they’re still the better team in this matchup and, in my eyes, probably a better team than their record to this point in the year. I’ll roll with the Brewers to draw first blood on the road in this one.

Chris Ruffolo's Pick: Milwaukee Brewers -125

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