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Mets vs Nationals Prediction 8/21/2025 Today’s MLB Picks

Aug 10, 2025; Milwaukee, Wisconsin, USA; New York Mets starting pitcher Sean Manaea (59) throws a pitch in the first inning against the Milwaukee Brewers at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images

Aug 10, 2025; Milwaukee, Wisconsin, USA; New York Mets starting pitcher Sean Manaea (59) throws a pitch in the first inning against the Milwaukee Brewers at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images

New York (67-59) vs Washington (51-75)

August 21, 2025 at 04:05 PM EDT

The Line: Betting Odds: Washington +1.5 — Over/Under: +8.5

(Get latest betting odds)

In this article we will formulate a Mets vs Nationals prediction for this MLB game on Thursday, August 21st at Nationals Park in Washington, DC. Let’s take a look at the prediction for this MLB matchup. 

New York Mets Betting Preview

The New York Mets are 67-59 this year after they split the first two games in this series by scores of 8-1 and 4-5. In their game two loss, New York cut the deficit to 5-4 in the sixth inning, but couldn’t find anymore offense in the loss. The Mets recorded eight hits and they committed one error in the game, while they were led by McNeil, who went 1-4 with two RBIs in the loss. New York started Senga, who allowed six hits and four earned runs over 5.0 innings for the loss, while Rogers, Soto, and Garrett allowed zero earned runs in relief. 

Prior to this series, the Mets won two out of three against the Mariners, but did lose two out of three against the Braves before that. New York has won three of their last four games and they are currently second in the NL East standings. The New York pitching staff has a 3.76 ERA with a 1.31 WHIP and a .240 opponent batting average, while the offense has scored 566 runs with a .244 batting average and a .321 on base percentage this season. Pete Alonso has led New York with 28 home runs and 101 RBIs, while Juan Soto has added 31 home runs and 72 RBIs this year. The projected starting pitcher for New York is Sean Manaea, who is 1-1 with a 4.78 ERA and a 1.16 WHIP over 32.0 innings pitched this year. 

Washington Nationals Betting Preview

The Washington Nationals are 51-75 this season after they won game two by a score of 5-4 on Wednesday night. Washington jumped out to a 5-1 lead in the fifth inning, but didn’t score anymore runs and barely hung on for the win. The Nationals recorded seven hits and they committed one error in the game, while they were led by Bell, who went 1-3 with one home run and two RBIs in the win. Washington started Lord, who allowed seven hits and four earned runs over 5.1 innings for the win, while Ferrer picked up the save. 

Prior to this series, the Nationals split four games with the Phillies and lost two out of three against the Royals. Washington has lost three of their last five games and they are currently last in the NL East standings. The Washington pitching staff has a 5.34 ERA with a 1.44 WHIP and a .271 opponent batting average, while the offense has scored 537 runs with a .244 batting average and a .308 on base percentage this season. James Wood has led Washington with 25 home runs and 80 RBIs, while CJ Abrams has added 16 home runs and 50 RBIs this year. The projected starting pitcher for Washington is MacKenzie Gore, who is 5-12 with a 4.04 ERA and a 1.32 WHIP over 138.0 innings pitched this season. 

Why the Nationals will beat the Mets 

  • The Mets have lost nine of their last 10 games as favorites after playing the previous day.
  • The Nationals have won four of their last six games as underdogs after playing the previous day.
  • The Mets have failed to cover the run line in nine of their last 10 games as favorites after playing the previous day.
  • The Nationals have covered the run line in three of their last four day games against teams that held a winning record.
  • The Nationals have led after 5 innings in three of their last four day games against National League opponents that held a winning record.

    Total Runs Facts

    • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Mets’ last four games.
    • The ‘Inning 1 UNDER 0.5 runs’ market has hit in 17 of the last 22 games between the Mets and Nationals.

    Washington Nationals Player Prop Facts

    • MacKenzie Gore has recorded seven or more strikeouts in six of his last seven appearances at Nationals Park against NL opponents that held a winning record.
    • Paul DeJong has hit a home run in two of his last three appearances in day games.
    • Paul DeJong has recorded at least one hit in each of his last 11 appearances against NL opponents.

    New York Mets Player Prop Facts

    • Brett Baty has hit a home run in each of the Mets’ last three road games.
    • Jeff McNeil has recorded at least one hit in each of his last eight appearances against the Nationals.
    • Juan Soto has recorded a Double in each of the Mets’ last three day games against NL East opponents that held a losing record.
    • Sean Manaea has recorded six strikeouts in each of his last three appearances against NL East opponents.

    Mets vs Nationals Prediction

    New York had their small winning streak come to an end on Wednesday night, but their offense continues to hit the ball well. The Mets are 26-35 on the road this year, while the Nationals are 25-39 at home. Washington has scored 15 runs in their last five games and they are going against Manaea, who has allowed 4, 4, and 5 earned runs in his last three outings. The Mets will face Gore, who has allowed a total of two earned runs in his last 12.0 innings. We have seen Gore bounce back from a couple of rough starts and I can’t trust Manaea right now, so give me the Nats to win. 

    David Racey's Pick: Nationals ML

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