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Los Angeles Dodgers vs San Francisco Giants Prediction 9/13/2025 Today’s MLB Picks

Sep 10, 2025; Los Angeles, California, USA; Los Angeles Dodgers shortstop Mookie Betts (50) hits a grand slam home run during the eighth inning against the Colorado Rockies at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Sep 10, 2025; Los Angeles, California, USA; Los Angeles Dodgers shortstop Mookie Betts (50) hits a grand slam home run during the eighth inning against the Colorado Rockies at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Los Angeles (82-65) vs San Francisco (75-72)

September 13, 2025 at 09:05 PM EDT

The Line: Betting Odds: San Francisco +125 — Over/Under: +7.5

(Get latest betting odds)

The Los Angeles Dodgers and the San Francisco Giants meet Saturday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Clayton Kershaw for the start here and Kershaw is 10-2 with a 3.27 ERA and 69 strikeouts this season. In his last five starts against the Giants, Kershaw is 3-1 with a 1.98 ERA and 25 strikeouts. Logan Webb will get the nod for the Giants and is 14-9 with a 3.12 ERA and 201 strikeouts this season. In his last five starts against the Dodgers, Webb is 3-0 with a 4.15 ERA and 25 strikeouts. 

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to rebound from their 5-1 loss at the hands of the Giants in Friday’s series opener to sit at 82-65 this season. After this series, the Dodgers will make the short trip home for a series against the Philadelphia Phillies.

Dodgers Have Four-Game Win Streak Snapped

Shohei Ohtani has 152 hits including 21 doubles, 48 home runs, 90 RBIs and 8 triples . Michael Conforto has 73 hits with 20 doubles while Teoscar Hernandez has 107 hits with 21 home runs, 25 doubles and 78 RBIs as well this season. Ohtani has a team-high 17 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 16 home runs and 67 RBIs as well on the year. Freddie Freeman has also logged 144 hits with a team-high 37 doubles, 19 home runs and 78 RBIs. Andy Pages also has 139 hits with 22 doubles, 24 home runs and 79 RBIs as well this season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their walk-off win over the Dodgers from Friday’s matchup to improve to 75-72 this season. After this series, the Giants will take to the road for a series rematch with the Arizona Diamondbacks.

Giants Win 7 Of Their Last 10

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 51 RBIs with 10 stolen bases while Heliot Ramos has 146 hits with 23 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 96 hits with 21 home runs and 56 RBIs along with 19 doubles and Willy Adames has 122 hits with 19 doubles, 28 home runs and 81 RBIs of his own this season. 

Los Angeles Dodgers @ San Francisco Giants Betting Trends: September 13, 2025

  • Probable Starting Pitcher: Logan Webb      Record this season: 14-9      ERA: 3.12
  • Home Record: 7-3
  • Last 5 against Dodgers: 3-0

Why the San Francisco Giants will win

  • The Dodgers have lost each of their last four games as road favorites against National League opponents.
  • The Giants have won six of their last seven games as underdogs against National League opponents.
  • The Giants have covered the run line in each of their last eight games as underdogs against National League opponents.
  • The Dodgers have failed to cover the run line in each of their last nine Saturday road games.
  • The Dodgers have trailed after 5 innings in each of their last four road games against opponents that held a winning record.
  • The Giants have won the first inning in four of their last five games as underdogs.
  • The Dodgers have trailed after 3 innings in each of their last five road games against National League opponents.
  • Probable Starting Pitcher: Clayton Kershaw      Record this season: 10-2      ERA: 3.27
  • Road Record: 5-2
  • Last 5 against Giants: 3-1

Why the Los Angeles Dodgers will win

  • The Giants have lost each of their last eight games against the Dodgers following a win.
  • The Dodgers have won each of their last nine games as favorites against the Giants following a loss.
  • The Dodgers have covered the run line in each of their last nine night games at Oracle Park following a loss.
  • The Giants have failed to cover the run line in each of their last six night games against the Dodgers at Oracle Park following a win.
  • The Giants have trailed after 5 innings in five of their last six games as home underdogs against NL West opponents.

Total Runs Facts

  • Seven of the Giants’ last eight night games after playing the previous day have gone OVER the total runs line.
  • Each of the Dodgers’ last five games following an extra innings loss have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Giants’ last nine home games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Dodgers’ last nine night games against NL West opponents.

San Francisco Giants Player Prop Facts

  • Patrick Bailey has hit a home run in each of the Giants’ last three night games.
  • Logan Webb has recorded a win in each of his last four appearances with the Giants as underdogs.
  • Logan Webb has recorded six or more strikeouts in 10 of his last 12 home appearances against NL opponents.
  • Patrick Bailey has recorded at least one hit in each of the Giants’ last seven home games against the Dodgers.
  • Logan Webb ranks 4th in the league for total Strikeouts (201) this season.

Los Angeles Dodgers Player Prop Facts

  • Michael Conforto has hit a home run in each of the Dodgers’ last two games against opponents that held a winning record.
  • Clayton Kershaw has recorded a win in each of his last four appearances against NL West opponents.
  • Clayton Kershaw has recorded four or more strikeouts in each of his last 12 appearances against the Giants.
  • Miguel Rojas has recorded at least one hit in 13 of his last 14 road appearances against NL opponents.
  • Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.607) this season.

Matchup/League Facts

  • The Giants rank 1st in the league for home runs allowed this season (126).
  • The Giants rank 29th in the league for steals this season (64).
  • The Dodgers rank 2nd in the league for home runs this season (216).
  • The Dodgers rank 2nd in the league for slugging percentage this season (.436).

Los Angeles Dodgers vs. San Francisco Giants Prediction

I’m on the under in this one. I think this is a solid pitching matchup while you also have two offensive units that haven’t been producing as of late, the Giants against lefties and the Dodgers overall for that matter. We had an extra innings game that had just two runs entering extras on Friday and I could see something similar here. Give me the under in this one.

Chris Ruffolo's Pick: Under 7.5

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