Los Angeles (73-55) vs San Diego (72-56)
August 22, 2025 at 09:40 PM EDT
The Line: Betting Odds: San Diego +1.5 — Over/Under: +8
The Los Angeles Dodgers and San Diego Padres meet Friday in MLB action at Petco Park. Here’s a Los Angeles Dodgers vs San Diego Padres Prediction. This article will include a Los Angeles Dodgers vs San Diego Padres Pick.
Los Angeles Dodgers Betting Preview
The Los Angeles Dodgers are 73-55 on the year and play the Reds, Diamondbacks, and Pirates next. The Los Angeles Dodgers are batting .255 on the season, have a .332 OBP, and a .441 slugging percentage. The Los Angeles Dodgers pitching staff has a 4.16 ERA and a 1.31 WHIP. Shohei Ohtani leads the Los Angeles Dodgers with 138 hits and 83 RBI, while Freddie Freeman and Andy Pages have combined for 258 hits and 143 RBI.
Blake Snell gets the ball for the Los Angeles Dodgers, and he is 3-1 with a 1.80 ERA and 25 strikeouts this season. Snell is 2-0 with a 0.82 ERA and 11 strikeouts in his career against the San Diego Padres.
San Diego Padres Betting Preview
The San Diego Padres are 72-56 on the year and play the Mariners, Twins, and Orioles next. The San Diego Padres are batting .252 on the season, have a .322 OBP, and a .385 slugging percentage. The San Diego Padres pitching staff has a 3.54 ERA and a 1.20 WHIP. Manny Machado leads the San Diego Padres with 145 hits and 77 RBI while Luis Arraez and Fernando Tatis Jr. have combined for 272 hits and 99 RBI.
Yu Darvish gets the ball for the San Diego Padres, and he is 2-3 with a 5.97 ERA and 34 strikeouts this season. Darvish is 5-5 with a 2.55 ERA and 109 strikeouts in his career against the Los Angeles Dodgers.
Why the San Diego Padres will win
The Dodgers have lost each of their last four games as favorites following a road win.
The Padres have won four of their last five games as home underdogs against National League opponents.
The Padres have covered the run line in each of their last 10 games as underdogs following a win.
The Dodgers have failed to cover the run line in 13 of their last 14 night games against National League opponents following a road win.
The Dodgers have trailed after 3 innings in five of their last six games at Petco Park.
Why the Los Angeles Dodgers will win
The Padres have lost each of their last five games against the Dodgers following a win.
The Dodgers have won each of their last five games against NL West opponents that held a winning record.
The Padres have failed to cover the run line in five of their last six games against the Dodgers at Petco Park following a home win.
The favorites have covered the run line in four of the Padres’ last five games at Petco Park.
The Padres have trailed after 3 innings in each of their last three games against National League opponents that held a winning record.
The Padres have trailed after 5 innings in each of their last three games against National League opponents that held a winning record.
San Diego Padres Player Prop Facts
Manny Machado has hit a home run in three of the Padres’ last five games as home underdogs against NL opponents.
Yu Darvish has recorded six or more strikeouts in nine of his 10 previous appearances at Petco Park against NL West opponents that held a winning record.
Yu Darvish has recorded a win in three of his last four appearances at Petco Park against NL opponents that held a winning record.
Jackson Merrill has recorded a Double in three of his last four appearances in night games.
Gavin Sheets has recorded at least one hit in each of his last 10 appearances with his team as an underdog against the Dodgers.
Luis Arraez ranks 5th in the league in Hits (144) this season.
Los Angeles Dodgers Player Prop Facts
Teoscar Hernandez has hit a home run in each of the Dodgers’ last two night games against opponents that held a winning record.
Miguel Rojas has recorded at least one hit in each of his last 11 road appearances against NL West opponents.
Blake Snell has recorded seven or more strikeouts in each of his last six appearances with his team as a road favorite against NL West opponents.
Blake Snell has recorded a win in each of his last four appearances in night games against teams that held a winning record.
Will Smith ranks 2nd amongst qualified players for On Base Percentage (.410) this season.
Los Angeles Dodgers vs San Diego Padres Prediction
The Padres are putting together a solid week, and we know what Darvish is capable of when he’s right, but he’s struggled with consistency this season and has allowed 10 hits and 8 runs in his last 14 innings. Snell hasn’t allowed a run in his last 11 innings, and he’s allowed three earned runs in his last 20 innings. In 106 at bats against current Padres, Snell has a .217 allowed batting average and .297 on base percentage, with 30 strikeouts. Darvish needs to find his form before he can be trusted. Snell has owned this Padres lineup and is dealing. Give me the Dodgers.