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Los Angeles Dodgers vs Philadelphia Phillies Prediction 10/6/2025 Today’s MLB Picks

Sep 21, 2025; Phoenix, Arizona, USA; Philadelphia Phillies infielder Bryce Harper (3) singles on a sharp line drive to center in the ninth inning against the Arizona Diamondbacks at Chase Field. Mandatory Credit: Allan Henry-Imagn Images

Sep 21, 2025; Phoenix, Arizona, USA; Philadelphia Phillies infielder Bryce Harper (3) singles on a sharp line drive to center in the ninth inning against the Arizona Diamondbacks at Chase Field. Mandatory Credit: Allan Henry-Imagn Images

Los Angeles (93-69) vs Philadelphia (96-66)

October 6, 2025 at 06:08 PM EDT

The Line: Betting Odds: Philadelphia +115 — Over/Under: +7.5

(Get latest betting odds)

The Los Angeles Dodgers and the Philadelphia Phillies meet Monday in MLB action from Citizens Bank Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. Philadelphia Phillies prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Blake Snell and Snell is 5-4 with a 2.35 ERA and 72 strikeouts this season. Jesus Luzardo will get the start for the Phillies here and is 15-7 with a 3.92 ERA and 216 strikeouts this season. 

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on their 5-3 win over the Phillies from Saturday’s series opener.

Dodgers Looking To Push Phillies To The Brink

Shohei Ohtani has 172 hits including 25 doubles, 55 home runs, 102 RBIs and 9 triples. Michael Conforto has 83 hits with 20 doubles while Teoscar Hernandez has 126 hits with 25 home runs, 29 doubles and 89 RBIs as well this season. Ohtani has a team-high 20 stolen bases while Max Muncy has 10 doubles but also has 83 strikeouts so far this season. Mookie Betts has also chipped in 20 home runs and 82 RBIs as well on the year. Freddie Freeman has also logged 164 hits with a team-high 39 doubles, 24 home runs and 90 RBIs. Andy Pages also has 158 hits with 27 doubles, 27 home runs and 86 RBIs as well this season.

Philadelphia Phillies Recap

The Philadelphia Phillies will hope to rebound after falling apart in the later innings of game one, falling behind in the series as a result.

Phillies Trying To Make It A Best-Of-3

Nick Castellanos has 137 hits with 27 doubles including 17 home runs and 72 RBIs while Kyle Schwarber has 145 hits with a team-high 56 home runs and 132 RBIs but also has a team-high 197 strikeouts as well on the year. Bryce Harper has 12 stolen bases, 32 doubles, 27 home runs and 75 RBIs. Trea Turner also has 179 hits with 7 triples, 15 home runs, 69 RBIs and a team-high 36 stolen bases. Max Kepler has 19 doubles and Bryson Stott has 22 doubles, 3 triples, 13 homers and 66 RBIs while Stott also has 24 stolen bases as well this season.

Los Angeles Dodgers @ Philadelphia Phillies Betting Trends: October 6, 2025

  • Probable Starting Pitcher: Jesus Luzardo      Record this season: 15-7      ERA: 3.92
  • Home Record: 8-2
  • Last 5 against Dodgers: 1-1

Why the Philadelphia Phillies will win

  • The Phillies have won each of their last 15 games following a home loss.
  • The Dodgers have lost each of their last five games as road favorites against the Phillies following a win.
  • The Phillies have covered the run line in each of their last eight games against National League opponents following a home loss.
  • The Dodgers have failed to cover the run line in each of their last six games as favorites against NL East opponents following a win.
  • The Dodgers have lost the first inning in three of their last four night games at Citizens Bank Park.
  • The Phillies have led after 5 innings in each of their last seven night games against the Dodgers at Citizens Bank Park.
  • The Phillies have led after 3 innings in nine of their last 10 home games against opponents that held a winning record.
  • Probable Starting Pitcher: Blake Snell      Record this season (inc. playoffs): 6-4      ERA: 2.37
  • Road Record: 0-3
  • Last 5 against Phillies: 2-1

Why the Los Angeles Dodgers will win

  • The Dodgers have won each of their last eight games.
  • The Phillies have lost each of their last five playoff games after not playing the previous day.
  • The Dodgers have covered the run line in each of their last 10 playoff games after not playing the previous day.
  • The Phillies have failed to cover the run line in each of their last seven playoff games.
  • The Dodgers have led after 5 innings in each of their last six games as favorites.
  • The Dodgers have led after 3 innings in four of their last five games as road favorites.

Total Runs Facts

  • Each of the Dodgers’ last seven playoff games against NL East opponents have gone OVER the total runs line.
  • Each of the Phillies’ last four playoff games as home underdogs have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Phillies’ last eight games as home underdogs.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Dodgers’ last six games at Citizens Bank Park.

Philadelphia Phillies Player Prop Facts

  • Kyle Schwarber has hit a home run in three of the Phillies’ last four playoff games as home underdogs.
  • Alec Bohm has recorded at least one hit in each of his last 10 appearances with the Phillies as underdogs against NL opponents.
  • Max Kepler has recorded a Double in each of his last three playoff appearances after not playing the previous day.
  • Kyle Schwarber ranks 2nd in the league in Home Runs (56) this season.

Los Angeles Dodgers Player Prop Facts

  • Teoscar Hernandez has recorded a Double in four of his last five road appearances against NL East opponents.
  • Shohei Ohtani has hit at least one home run in three of the Dodgers’ last four games as favorites.
  • Andy Pages has recorded at least one hit in each of the Dodgers’ last 14 games as favorites against NL East opponents.
  • Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.622) this season.

Matchup/League Facts

  • The Phillies rank 2nd in the league for hits this season (1426).
  • The Phillies rank 2nd in the league for batting average this season (.258).
  • The Dodgers rank 1st in the league for strikeouts this season (1505).
  • The Dodgers rank 2nd in the league for runs scored this season (825).

Los Angeles Dodgers vs. Philadelphia Phillies Prediction

I’m on the over in this one. Blake Snell was far less effective on the road this season as his opponent’s batting average is 100 percentage points higher away from Dodger Stadium than it was at home, but I’m also not trusting Jesus Luzardo, who did have an ERA over four at home this season and despite tossing seven plus innings in each of his last three starts of the season, he did give up four runs in two of those three outings as well. These were two teams that hit left-handed pitching really well in the month of September, and I think that continues here as we get a high-scoring matchup. Give me the over here.

Chris Ruffolo's Pick: OVER 7.5

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