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Los Angeles Angels vs Houston Astros Prediction 4/12/25 MLB Picks

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Houston Astros (6-7) vs Los Angeles Angels (8-5)

Game Info: Saturday, April 12, 2025 at 7:10 pm (Daikin Park)

The Line: Betting Odds: Houston Astros -148 / Los Angeles Angels +124 — Over/Under: 9

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The Los Angeles Angels and the Houston Astros meet Saturday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs. Houston Astros prediction.

Starting Pitching Matchup

Tyler Anderson will start this game for the Angels and is 0-0 with a 4.50 ERA and 9 strikeouts this season. In his last five starts against the Astros, Anderson is 1-4 with a 6.49 ERA and 21 strikeouts. Ryan Gusto will get the start for the Astros here and is 1-0 with a 1.13 ERA and 9 strikeouts this season. This will be Gusto’s first career start against the Angels.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to bounce back after ending up on the wrong side of a 14-3 loss at the hands of the Astros in Friday’s series opener. After this set, the Angels will head on the road for another division series against the Texas Rangers.

Angels Win 5 Of Their Last 7 Despite Loss

Logan O’Hoppe has 14 hits including a team-high 5 home runs and 9 RBIs while Nolan Schanuel has 14 hits with 3 doubles, a triple and 5 RBIs. Luis Rengifo has a team-high 4 doubles with his 11 hits and Taylor Ward also has 12 hits as well while Mike Trout’s added 6 home runs and 12 RBIs so far this season. Jorge Soler also has 3 home runs, but also has the unfortunate distinction of leading the Angels with 18 strikeouts so far this season. Kyren Paris has also chipped in 13 hits with a triple, 5 home runs and 8 RBIs.

Why the Los Angeles Angels will win

Los Angeles Angels Player Prop Facts

Houston Astros Recap

The Houston Astros will be out to keep the offensive momentum going after starting the series with a blowout win over the Angels on Friday. After this series, the Astros will head on the road for a series against the St. Louis Cardinals.

Astros Still Looking For Consistency After Alternating Wins & Losses In 8 Straight

Jose Altuve leads the Astros with 19 hits including 3 home runs and 6 RBIs. Jeremy Pena also has a pair of homers and 4 stolen bases while Yordan Alvarez has a double and a team-high 9 RBIs with 13 strikeouts as well. Brendan Rodgers has a pair of doubles while Jake Meyers has a pair of doubles as well and Christian Walker has also accrued a team-high 18 strikeouts so far this season. Altuve also has 3 stolen bases while Jake Meyers has a team-high 5 stolen bases this season.

Why the Houston Astros will win

Houston Astros Player Prop Facts

Total Runs Facts

Los Angeles Angels vs. Houston Astros Prediction

I’m leaning towards the Astros. Maybe Friday’s win was what the doctor ordered for the Astros to get back on track and the Astros historically have been a solid team to back against left-handed pitching, which they’ve barely seen any of this season. Anderson is a pitcher that normally gives up a lot of runs and a lot of hard contact and I could see him getting hit hard once again by the Astros here. Give me Houston at home here.

Chris Ruffolo's Pick: Houston Astros -148

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