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Los Angeles Angels vs Colorado Rockies Prediction 9/20/2025 Today’s MLB Picks

Sep 19, 2025; Denver, Colorado, USA; Los Angeles Angels third baseman Yoan Moncada (5) hits a sacrifice fly RBI in the fifth inning against the Colorado Rockies at Coors Field. Mandatory Credit: Isaiah J. Downing-Imagn Images

Sep 19, 2025; Denver, Colorado, USA; Los Angeles Angels third baseman Yoan Moncada (5) hits a sacrifice fly RBI in the fifth inning against the Colorado Rockies at Coors Field. Mandatory Credit: Isaiah J. Downing-Imagn Images

Los Angeles (69-85) vs Colorado (42-112)

September 20, 2025 at 08:10 PM EDT

The Line: Betting Odds: Angels -130 — Over/Under: +11.5

(Get latest betting odds)

In this article, we will formulate an Angels vs Rockies Prediction for this MLB game on Saturday, September 209th at the Coors Field in the second game of this series, with the Rockies having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Colorado Rockies Preview

The Colorado Rockies have a 42-112 record this season and are sitting on the last place of the NL West. The Rockies have a 24-55 home record and are 69-80 in over/under. They are coming off a 7-6 home victory over the Angels, that ended their five-game losing streak. Over is 6-0 in their last 6 games, and are playing the Mariners and the Giants next.

The Rockies have a .240 batting average this season, .296 OBP and .391 Slugging percentage. Colorado’s pitching staff has a 6.04 ERA and 1.60 WHIP. Hunter Goodman leads the Rockies with 142 hits, also leading the team both in RBI, with 88, and in home runs, with 30. He is also the team’s best hitter with a .280 batting average.

German Marquez (R) is the projected starting pitcher for the Rockies, and he has a 3-14 record, 6.73 ERA and 1.77 WHIP.

Los Angeles Angels Preview

The Los Angeles Angels have a 69-85 record this season and are sitting on the 4th place of the AL West. The Angels have a 32-47 road record and 85-66 in over/under They are coming off a 6-7 road defeat by the Rockies, and have seven consecutive losses. Over is 10-3 in their last 13 games and are playing the Astros and the Royals next.

The Angels have a .227 batting average this season, .300 OBP and .399 Slugging percentage. LA’s pitching staff has a 4.90 ERA and 1.45 WHIP. Zach Neto leads the Angels with 129 hits, while Nolan Schanuel is the team’s best hitter with a .268 batting average. Taylor Ward leads the team with 100 RBI, while Jo Adell adds a team-high 36 home runs.

Kyle Hendricks (L) is the projected starting pitcher for the Angels, and he has a 7-10 record, 5.01 ERA and 1.32 WHIP.

Los Angeles Angels @ Colorado Rockies Betting Trends: September 20, 2025

  • Probable Starting Pitcher: German Marquez      Record this season: 3-14      ERA: 6.73
  • Home Record: 1-8
  • Last 5 against Angels: 0-1

Why the Colorado Rockies will win

  • The home team has won each of the Angels’ last 10 games.
  • The Angels have lost each of their last nine road games.
  • The Angels have failed to cover the run line in each of their last 17 games as road favorites.
  • The home team has covered the run line in each of the Angels’ last six games.
  • The Angels have lost the first inning in four of their last five road games against opponents that held a losing record.
  • The Angels have trailed after 5 innings in eight of their last nine night games against opponents that held a losing record.
  • The Rockies have led after 3 innings in five of their last six night games against AL West opponents that held a losing record.

  • Probable Starting Pitcher: Kyle Hendricks      Record this season: 7-10      ERA: 5.01
  • Road Record: 2-5
  • Last 5 against Rockies: 2-2

Why the Los Angeles Angels will win

  • The Rockies have lost each of their last six games following a win.
  • The Angels have won seven of their last eight night games against NL West opponents.
  • The Rockies have failed to cover the run line in each of their last six games following a win.
  • The Angels have covered the run line in four of their last five night games against NL West opponents.
  • The Rockies have trailed after 3 innings in eight of their last 10 games.
  • The Angels have won the first inning in four of their last five night games against National League opponents that held a losing record.
  • The Rockies have trailed after 5 innings in each of their last eight Saturday games.

Total Runs Facts

  • Each of the Angels’ last seven night games against NL West opponents have gone OVER the total runs line.
  • Each of the Rockies’ last six games have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last 10 night games against NL West opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rockies’ last six games as home underdogs against AL West opponents.

Colorado Rockies Player Prop Facts

  • Tyler Freeman has recorded at least one Double in each of his last five home appearances against AL opponents that held a losing record.
  • German Marquez has recorded five or more strikeouts in seven of his last eight home appearances against AL West opponents.
  • Brenton Doyle has recorded at least one hit in each of his last eight Saturday appearances against teams that held a losing record.
  • Kyle Farmer has hit a home run in each of his last two home appearances after playing the previous day.

Los Angeles Angels Player Prop Facts

  • Kyle Hendricks has recorded a win in five of his last six appearances with his team as a road favorite against NL West opponents .
  • Taylor Ward has recorded two hits in each of his last seven appearances with the Angels as road favorites against NL opponents.
  • Kyle Hendricks has recorded four or more strikeouts in 13 of his last 15 appearances with his team as a favorite against NL West opponents.
  • Zach Neto has hit a home run in four of his last five road appearances against opponents that held a losing record.
  • Jo Adell ranks 9th in the league in Home Runs (36) this season.

Matchup/League Facts

  • The Rockies rank 30th in the league for on-base percentage this season (.296).
  • The Rockies rank 30th in the league for walks this season (379).
  • The Angels rank 30th in the league for doubles this season (205).
  • The Angels rank 30th in the league for strikeouts against this season (1550).

Angels vs Rockies Prediction

The Rockies are 4-1 in their last 5 head-to-head meetings the Angels, and are 3-2 in their last 5 meetings in Colorado. Over is 7-3 in their last 10 meetings.

In this Angels vs Rockies Prediction, the Angels are coming as -130 road favorites. I don’t trust either team at this point for the season, as neither is interested to win. Both pitchers have been terrible, with a combined 11.74 ERA, and Hendricks has been even weaker on the road for the Angels, with a 5.78 ERA. Marquez has been absolutely horrendous lately, having lost his last 5 starts with a 12.36 ERA in that span, so I expect fireworks offensively in this game. Take the over 11.5 runs in this one.

Nikos Lagouretos's Pick: Over 11.5

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