Los Angeles Angels vs Boston Red Sox Prediction 6/4/25 MLB Picks

The Los Angeles Angels and the Boston Red Sox meet Wednesday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs. Boston Red Sox prediction.

Starting Pitching Matchup

The Los Angeles Angels will send out Jose Soriano for the start here and is 4-5 with a 3.41 ERA and 49 strikeouts this season. This will be Soriano’s first career start against the Red Sox. The Boston Red Sox will trot out Lucas Giolito for the start here and is 1-1 with a 4.78 ERA and 26 strikeouts this season. In his last five starts against the Angels, Giolito is 2-2 with a 4.06 ERA and 36 strikeouts.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to build on their 4-3 win over the Boston Red Sox last time out to improve to 28-32 on the year. After this series, the Angels will head home for a series against the Seattle Mariners.

Angels Win Back-To-Back Games

Logan O’Hoppe has 46 hits, including 14 home runs and 30 RBIs, while Nolan Schanuel has 53 hits with 9 doubles, a triple, 3 home runs, and 14 RBIs. Luis Rengifo has 7 doubles with his 40 hits, and Taylor Ward also has 49 hits as well, while Mike Trout’s added 10 home runs and 23 RBIs so far this season. Jorge Soler also has 10 doubles, 8 home runs, and 24 RBIs, but also has 64 strikeouts so far this season. Kyren Paris has also chipped in 24 hits with a triple, 6 home runs, and 11 RBIs in addition to 7 stolen bases, while Jo Adell has 9 home runs and 26 RBIs. Ward has also chipped in 11 doubles, 16 home runs, and 38 RBIs, but has a team-high 67 strikeouts, while Zach Neto has 10 doubles, 10 home runs, 21 RBIs, and 8 stolen bases.

Why the Los Angeles Angels will win

• The underdogs have won eight of the Red Sox’s last nine games at Fenway Park.
• The Red Sox have lost each of their last five games as home favorites after playing the previous day.
• The Angels have covered the run line in each of their last 10 games as road underdogs against the Red Sox.
• The Red Sox have failed to cover the run line in each of their last six games as home favorites after playing the previous day.

Los Angeles Angels Player Prop Facts

• Logan O’Hoppe has hit at least one home run in three of his last four road appearances against opponents that held a losing record.
• Zach Neto has recorded at least one RBI in each of the Angels’ last five road games against opponents that held a losing record.
• Mike Trout has recorded at least one Single in each of his last seven appearances with the Angels as road underdogs against AL opponents.
• Zach Neto has scored at least one run in each of the Angels’ last six road games against opponents that held a losing record.
• Anthony Rendon has recorded at least one hit in each of his last nine appearances against the Red Sox.
• Taylor Ward ranks T6th in the league in Home Runs (16) this season.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to bounce back after their loss to the Angels in Tuesday’s matchup, dropping to 27-33 on the year. After this series, the Red Sox will head on the road for the biggest rivalry in baseball for a series with the New York Yankees.

Red Sox Drop Back-To-Back Games

Alex Bregman has 59 hits, including a team-high 17 doubles, along with 11 home runs and 35 RBIs, while Rafael Devers has added 66 hits with 17 doubles, 12 home runs and 53 RBIs this season. Trevor Story added 49 hits with 7 home runs, 26 RBIs, and 9 stolen bases, while Jarren Duran has 72 hits with 15 doubles, 6 triples, 4 home runs, 34 RBIs, and a team-high 13 stolen bases. Kristian Campbell added 43 hits with 8 doubles, 5 homers, and 16 RBIs while Wilyer Abreu has 13 home runs with 29 RBIs and 4 stolen bases, and Ceddanne Rafaela has 4 homers, 2 triples, 21 RBIs, and 7 stolen bases this season.

Why the Boston Red Sox will win

• The Angels have lost each of their last eight day games against AL East opponents following a win.
• The Red Sox have won five of their last six day games against AL West opponents that held a losing record.
• The Angels have failed to cover the run line in eight of their last nine day games against American League opponents.
• The Red Sox have covered the run line in each of their last four games following an extra-innings loss.

Boston Red Sox Player Prop Facts

• Lucas Giolito has recorded a win in three of his last four appearances with his team as a home favorite against AL opponents.
• Ceddanne Rafaela has scored at least one run in each of his last six appearances with the Red Sox as favorites against AL West opponents.
• Lucas Giolito has recorded six or more strikeouts in eight of his last nine appearances against the Angels.
• Jarren Duran has recorded at least one Single in each of the Red Sox’s last 10 Wednesday games at Fenway Park.
• Ceddanne Rafaela has recorded at least one hit in each of the Red Sox’s last seven games.
• Triston Casas has hit a home run in four of his last five home appearances against AL West opponents.
• Masataka Yoshida has recorded a Double in three of his last four appearances with the Red Sox as home favorites against AL opponents.
• Triston Casas has recorded at least one RBI in four of his last five home appearances against AL West opponents.
• Jarren Duran ranks 3rd in the league in Hits (74) this season.

Total Runs Facts

• Each of the Red Sox’s last five day games against AL West opponents have gone UNDER the total runs line.
• Five of the Angels’ last six day games against American League opponents have gone OVER the total runs line.

Los Angeles Angels vs. Boston Red Sox Prediction

I’m leaning towards the Angels here. The Red Sox just continue to freefall, and I don’t think it’s going to get any better with Lucas Giolito on the mound, given his struggles at Fenway, and I think that the Angels and their lineup that’s starting to get healthy can do enough to snag the win. Give me the Halos here.

Chris Ruffolo's Pick: Los Angeles Angels +114