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Kansas City Royals vs St. Louis Cardinals Prediction 5/16/2026 Today’s MLB Picks

May 15, 2026; St. Louis, Missouri, USA; St. Louis Cardinals pinch hitter Yohel Pozo (63) celebrates with teammates after hitting a wall-off one run single against the Kansas City Royals during the eleventh inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

May 15, 2026; St. Louis, Missouri, USA; St. Louis Cardinals pinch hitter Yohel Pozo (63) celebrates with teammates after hitting a wall-off one run single against the Kansas City Royals during the eleventh inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP Kansas City Royals St. Louis Cardinals
Team Records 19-26 26-18
Spread -1.5 151 +1.5 -184
Moneyline -102 -119
Total Over 9 (-111) Under 9 (-108)
Where Busch Stadium, St. Louis, Missouri
When Saturday, May 16, 2026
Time 02:15 PM EDT
TV MLB.TV
The Kansas City Royals and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Kansas City Royals vs. St. Louis Cardinals Prediction. This article will include a Kansas City Royals vs. St. Louis Cardinals Pick.

Kansas City Royals Betting Preview


The Kansas City Royals are 19-26 on the year and play the Red Sox and Mariners next. The Kansas City Royals are batting .239 on the season, have a .318 OBP, and have a .385 slugging percentage. The Kansas City Royals’ pitching staff has a 4.38 ERA and a 1.38 WHIP. Bobby Witt Jr. leads the Kansas City Royals with 55 hits and 23 RBI while Maikel Garcia and Salvador Perez have combined for 79 hits and 36 RBI.

Noah Cameron gets the ball for the Kansas City Royals, and he is 2-2 with a 5.55 ERA and 32 strikeouts this season. Cameron is 0-1 with a 0.73 ERA and 6 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview


The St. Louis Cardinals are 26-18 on the year and play the Reds and Pirates next. The St. Louis Cardinals are batting .242 on the season and have a .324 OBP, and a .393 slugging percentage. The St. Louis Cardinals pitching staff has a 4.24 ERA and a 1.37 WHIP. Jordan Walker leads the St. Louis Cardinals with 50 hits and 34 RBI while Alec Burleson and Ivan Herrera have combined for 90 hits and 51 RBI.

Kyle Leahy gets the ball for the St. Louis Cardinals, and he is 4-3 with a 4.31 ERA and 32 strikeouts this season. Leahy is 0-0 with a 1.93 ERA and 3 strikeouts in his career against the Kansas City Royals.

Why the St. Louis Cardinals will win

Why the Kansas City Royals will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Kansas City Royals Player Prop Facts

Matchup/League Facts

Kansas City Royals vs St. Louis Cardinals Prediction


The Royals are having a week from hell, where the losses continue to pile up and the pitching keeps getting rocked. The Cardinals have been one of the biggest overachievers this season and at some point we have to admit they’re a good team. The Royals are in awful form and Cameron has a 5.55 ERA and 1.63 WHIP through 35.2 innings. Give me the Cardinals.

Randy Chambers's Pick: St. Louis Cardinals

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