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Kansas City Royals vs Houston Astros Prediction 5/12/25 MLB Picks

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Houston Astros (20-19) vs Kansas City Royals (24-18)

Game Info: Monday, May 12, 2025 at 8:10 pm (Daikin Park)

The Line: Betting Odds: Houston Astros -118 / Kansas City Royals -102 — Over/Under: 8

(Get latest betting odds)

The Kansas City Royals are visiting the Houston Astros on Monday, May 12th at the Daikin Park in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Kansas City Royals vs Houston Astros Prediction. We will examine:

The Houston Astros’ recent form and player performance

The Kansas City Royals’ recent form and player performance

Recent betting trends and streaks involving the Houston Astros

Recent betting trends and streaks involving the Kansas City Royals

Recent betting trends in games played between the Kansas City Royals vs Houston Astros

A summary that ties it all together and produces a favorable betting outcome for the Kansas City Royals vs Houston Astros game

Houston Astros Preview

The Houston Astros have a 20-19 record this season and are sitting in second place in the AL West. The Astros have a 13-8 home record and 17-20 in over/under. They are coming off a 6-0 home victory over the Cincinnati Reds, and are 3-1 in their last 4 games. Under is 4-2 in their last 6 games. The Astros have a .248 batting average this season, a .322 OBP, and a .375 slugging percentage. Houston’s pitching staff has a 3.44 ERA and 1.14 WHIP. Jeremy Pena leads the Astros with 32 hits and a team-high 5 home runs, while Yainer Diaz leads the team in RBI with 21. Jake Meyers is the team’s best hitter, with a .291 batting average.

Ryan Gusto (R) will take the mound for the Astros, and he has a 3-1 record, 2.93 ERA, and 1.27 WHIP. He has been weaker at home with a 3.52 ERA across three starts, and he has given up 2+ runs in three of his four starts this season.  

Kansas City Royals Preview

The Kansas City Royals have a 24-18 record this season and are sitting in third place in the AL Central. The Royals have an 8-11 road record and are 14-27 in over/under. They are coming off a 1-3 home defeat by the Boston Red Sox, and have dropped two straight games following a seven-game winning streak. Under is 7-3 in their last 10 games. The Royals have a .242 batting average this season, a .300 OBP, and a .359 Slugging percentage. Kansas’ pitching staff has a 2.99 ERA and 1.17 WHIP. Bobby Witt Jr leads the Royals with 51 hits, and he is the team’s best hitter with a .315 batting average. Vinnie Pasquantino leads the team in RBI with 24, adding a team-high 6 home runs.

Michael Wacha (R) will take the mound for the Royals, and he has a 2-4 record, 2.98 ERA, and 1.15 WHIP. He has been weaker on the road with a 4.15 ERA across three starts, but he is coming off a shutout performance against the White Sox at home. In his previous start against the Astros this season, he had zero earned runs in 6 innings of work.

Why the Houston Astros will win

Why the Kansas City Royals will win

Total Runs Facts

Matchup/League Facts

Kansas City Royals vs Houston Astros Prediction

The Royals won their only series against the Astros this season by 2-1 wins, and are a commanding 5-1 in their last 6 meetings in Kansas City. Under is 4-2 in their last 6 meetings.

In this Kansas City Royals vs Houston Astros Prediction, the Astros are coming as -115 home favorites. This should be a pick ’em game, as the Royals have a better overall record, but have been below average on the road. Both teams have similarly good bullpens, but the Astros are hitting better. But Wacha has seen them already once this season, and he had a shutout performance against them. With the Royals struggling mightily to score, two solid pitchers on the mound, and two good bullpens, I don’t expect a high-scoring game. The total is set at 8.5, and I don’t expect nine runs to be scored in this game, so I will go with the under 8.5 runs.

Nikos Lagouretos's Pick: Under 8.5

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