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Houston Astros vs Toronto Blue Jays Prediction 6/22/2026 Today’s MLB Picks

Jun 20, 2026; Chicago, Illinois, USA; Toronto Blue Jays first baseman Vladimir Guerrero Jr. (27) celebrates after defeating the Chicago Cubs at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

Jun 20, 2026; Chicago, Illinois, USA; Toronto Blue Jays first baseman Vladimir Guerrero Jr. (27) celebrates after defeating the Chicago Cubs at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

MATCHUP Houston Astros Toronto Blue Jays
Team Records 37-42 38-39
Spread +1.5 -206 -1.5 168
Moneyline +104 -126
Total Over 7.5 (102) Under 7.5 (-123)
Where Rogers Centre, Toronto, Ontario
When Monday, June 22, 2026
Time 07:07 PM EDT
TV ESPN Unlmtd

The Houston Astros and the Toronto Blue Jays meet Monday in MLB action from Rogers Centre. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Toronto Blue Jays prediction.

Starting Pitching Matchup

The Houston Astros will send out Hunter Brown here and Brown is 1-0 with a 1.10 ERA and 24 strikeouts this season. The Toronto Blue Jays did not have a starting pitcher announced at the time that this article was posted.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their 2-1 win over the Cleveland Guardians last time out to sit at 37-42 this season. After this series, the Astros will head on the road for a series against the Detroit Tigers.

Astros Win 4 Of Last 5

Yordan Alvarez has 91 hits with 15 doubles, 25 home runs and 56 RBIs while Christian Walker has 70 hits with 14 doubles, 18 home runs and 52 RBIs on the year. Jose Altuve’s chipped in 50 hits with 11 doubles, 8 home runs and 20 RBIs and Isaac Paredes has 63 hits with 14 doubles, 10 home runs and 37 RBIs. Cam Smith also has 57 hits with 12 doubles, 7 home runs and 26 RBIs.

Toronto Blue Jays Recap

The Toronto Blue Jays come into this game looking to add on to their win over the Cubs by a final score of 8-6 on Saturday to improve to 38-39 this season before Sunday’s postponement. After this series, the Blue Jays will take on the Texas Rangers in a series at home.

Blue Jays Win 4 Of Last 5

Andres Gimenez has 56 hits with 11 doubles, a triple, 7 home runs and 33 RBIs while Ernie Clement has 85 hits with 20 doubles, 7 home runs and 28 RBIs. Kazuma Okamoto has 62 hits with 10 doubles, 16 home runs, 45 RBIs and a team-high 99 strikeouts while George Springer also has 11 doubles and 8 homers with 21 RBIs. Vladimir Guerrero Jr. has 74 hits with 12 doubles, 4 home runs and 31 RBIs as well. Jesus Sanchez also has 58 hits with 14 doubles, 7 home runs and 29 RBIs.

Houston Astros @ Toronto Blue Jays Betting Trends: June 22, 2026

Why the Toronto Blue Jays will win

Why the Houston Astros will win

Total Runs Facts

Toronto Blue Jays Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Houston Astros vs. Toronto Blue Jays Prediction

I’m on the Blue Jays here. I know Hunter Brown has looked solid in his limited action so far this season, but the Blue Jays have started to pick up their play once again and I think Toronto can get to Brown here. It’ll be interesting to see who Toronto throws out, as this was supposed to be the return of Shane Bieber but with Sunday’s postponement we could see Dylan Cease. Either way I think Toronto gets the better of the opener and gets the win here.

Chris Ruffolo's Pick: Toronto -110

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