Houston Astros vs Minnesota Twins Prediction 5/20/2026 Today’s MLB Picks

The Houston Astros and the Minnesota Twins meet Wednesday in MLB action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Minnesota Twins prediction.

Starting Pitching Matchup

The Houston Astros will send out Mike Burrows for the start here and Burrows is 2-5 with a 5.72 ERA and 46 strikeouts this season. This will be Burrows’ second career start against the Twins. The Minnesota Twins will start Joe Ryan here and Ryan is 2-3 with a 3.20 ERA and 52 strikeouts this season. In his last five starts against the Astros, Ryan is 1-3 with a 6.41 ERA and 31 strikeouts.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their 2-1 win over Minnesota from Tuesday to improve to 20-30 this season. After this series, the Astros will head on the road for a series against the Chicago Cubs.

Astros Snap Two-Game Slide

Yordan Alvarez has 55 hits with 11 doubles, 15 home runs and 31 RBIs while Christian Walker has 45 hits with 10 doubles, 11 home runs and 30 RBIs on the year. Jose Altuve’s chipped in 40 hits with 10 doubles, 4 home runs and 12 RBIs and Carlos Correa has 34 hits with 8 doubles, 3 home runs and 16 RBIs. Cam Smith also has 30 hits with 6 doubles, 4 home runs and 17 RBIs. Yainer Diaz also has 24 hits with 5 doubles, 2 home runs and 14 RBIs.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to bounce back from their loss at the hands of the Astros on Tuesday to slip to 22-27 this season. After this series, the Twins will head on the road for a series against the Boston Red Sox.

Twins Split Last 8 Games

Byron Buxton has 44 hits with 7 doubles, a triple, 15 home runs and 23 RBIs while Josh Bell’s added 34 hits with 8 doubles, 3 home runs and 24 RBIs. Luke Keaschall has 38 hits with 8 doubles, a homer and 15 RBIs and Matt Wallner has 20 hits with 3 doubles, 4 home runs and 10 RBIs. Brooks Lee has 5 home runs with 24 RBIs and Victor Caratini has 15 RBIs while Ryan Jeffers has 35 hits with 6 doubles, a triple, 7 home runs and 26 RBIs this season.

Houston Astros @ Minnesota Twins Betting Trends: May 20, 2026

• Probable Starting Pitcher: Joe Ryan      Record this season: 2-3      ERA: 3.20
• Home Record: 1-2
• Last 5 against Astros: 1-2

Why the Minnesota Twins will win

• The Astros have lost seven of their last eight games following a road win.
• The home team has won four of the last five games between the Astros and Twins.
• The Astros have failed to cover the run line in seven of their last eight games following a road win.
• The Twins have covered the run line in each of their last four games following a loss.
• The Twins have led after 5 innings in each of their last seven home day games.
• The Twins have won the first inning in six of their last eight day games at Target Field.
• The Twins have led after 3 innings in each of their last four home day games.

• Probable Starting Pitcher: Mike Burrows      Record this season: 2-5      ERA: 5.72
• Road Record: 1-3
• Last 5 against Twins: 0-1

Why the Houston Astros will win

• The Twins have lost 14 of their last 16 games as favorites after playing the previous day.
• The Astros have won each of their last six Wednesday games as underdogs against American League opponents.
• The Twins have failed to cover the run line in 14 of their last 16 games as favorites after playing the previous day.
• The Astros have covered the run line in each of their last six Wednesday games as underdogs against American League opponents.
• The Astros have led after 5 innings in four of their last five games against AL Central opponents.
• The Twins have trailed after 3 innings in each of their last five day games against AL West opponents that held a losing record.

Total Runs Facts

• Each of the Twins’ last four day games after playing the previous day have gone OVER the total runs line.
• Four of the Astros’ last five road games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last eight Wednesday day games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Twins’ last 12 home games against AL West opponents.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in four of his last five home appearances after playing the previous day.
• Joe Ryan has recorded a win in three of his last four appearances in day games against teams that held a losing record.
• Byron Buxton has recorded at least one hit in each of his last 11 Wednesday day appearances with the Twins as favorites.
• Byron Buxton ranks T5th in the league in Home Runs (15) this season.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in two of his last three appearances after playing the previous day.
• Isaac Paredes has recorded at least one hit in each of his last eight road appearances against AL Central opponents that held a losing record.
• Yordan Alvarez ranks 3rd amongst qualified players for On Base Percentage (.419) this season.

Matchup/League Facts

• The Twins rank 27th in the league for strikeouts this season (367).
• The Twins rank 24th in the league for runs allowed this season (230).
• The Astros rank 30th in the league for ERA this season (5.36).
• The Astros rank 30th in the league for walks allowed this season (246).

Houston Astros vs. Minnesota Twins Prediction

I’m backing the Twins here. I think Joe Ryan is the superior starting option here as Ryan is in some great form right now. On the flipside, the Astros sending out Burrows here is dicey as Burrows struggled in his lone start against the Twins and I think he’s one of the weaker links in Houston’s rotation right now so give me the Twins.

Chris Ruffolo's Pick: Minnesota -135