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Houston Astros vs Milwaukee Brewers Prediction 5/6/25 MLB Picks

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Mark Hoffman/Milwaukee Journal Sentinel / USA TODAY NETWORK via Imagn Images

Milwaukee Brewers (18-18) vs Houston Astros (17-17)

Game Info: Tuesday, May 6, 2025 at 7:40 pm (American Family Field)

The Line: Betting Odds: Milwaukee Brewers -115 / Houston Astros -105 — Over/Under: 8

(Get latest betting odds)

The Houston Astros and the Milwaukee Brewers meet Tuesday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Milwaukee Brewers prediction.

Starting Pitching Matchup

The Houston Astros will send out Hayden Wesneski for the start here, and Wesneski is 1-2 with a 3.86 ERA and 26 strikeouts this season. This will be Wesneski’s second career start against the Brewers. Chad Patrick will counter for the Milwaukee Brewers and is 1-3 with a 2.87 ERA and 26 strikeouts this season. This will be Patrick’s first career start against the Astros.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back from their series-opening 5-1 loss at the hands of the Brewers on Monday to fall to 17-17 on the year. After this series, the Astros will head home for a series against the Cincinnati Reds.

Astros Drop 4 Of Their Last 5

Jose Altuve has 35 hits, including 4 home runs and 14 RBIs. Jeremy Pena also has 36 hits with 4 homers and 12 RBIs with 5 stolen bases, while Yordan Alvarez has 4 doubles and a team-high 18 RBIs with 21 strikeouts as well. Jake Meyers has 5 doubles as well, and Christian Walker has also accrued a team-high 40 strikeouts so far this season. Altuve also has 3 stolen bases while Jake Meyers has a team-high 7 stolen bases this season. Isaac Paredes also has a team-high 4 home runs with 14 RBIs of his own, and Cam Smith has contributed 3 homers and 10 RBIs.

Why the Houston Astros will win

Houston Astros Player Prop Facts

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to build on their win over Houston from Monday’s series opener to improve to 18-18 on the year. After this series, the Brewers will head out on the road for a set against the Tampa Bay Rays.

Brewers Win Back-To-Back Games

Brice Turang has a team-high 41 hits with 3 home runs, 16 RBIs, and 8 stolen bases, while Jackson Chourio has 39 hits with a team-high 12 doubles, 6 home runs, and 24 RBIs, and Sal Frelick has 35 hits as well as 2 triples and 7 stolen bases so far this season. Christian Yelich also has 7 stolen bases with 6 homers and 25 RBIs while also adding 3 doubles. Yelich also has a team-high 38 strikeouts up to this point in the year. William Contreras has 3 homers and 19 RBIs as well this season.

Why the Milwaukee Brewers will win

Milwaukee Brewers Player Prop Facts

Total Runs Facts

Houston Astros vs. Milwaukee Brewers Prediction

I’m on the Brewers here. The problem for the Astros here is that the offense has been so wildly inconsistent this season that it makes it hard to rely on them on any given night. The Brewers have been hit and miss in their own right, but they’ve navigated a rough first couple of weeks of the season and have been playing some really solid baseball and are starting to have the bounces go their way for a change. I think this could be a launching point for the Brewers to go on a bit of a run, and I think they grab another win in this one. Give me the Brewers here.

Chris Ruffolo's Pick: Milwaukee Brewers -115

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