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Houston Astros vs Los Angeles Angels Prediction 9/28/2025 Today’s MLB Picks

Jul 11, 2025; Houston, Texas, USA; Houston Astros starting pitcher Lance McCullers Jr. (43) throws from the ground but is unable to get an out on an infield single by Texas Rangers first baseman Jake Burger (not pictured) during the third inning at Daikin Park. Mandatory Credit: Troy Taormina-Imagn Images

Jul 11, 2025; Houston, Texas, USA; Houston Astros starting pitcher Lance McCullers Jr. (43) throws from the ground but is unable to get an out on an infield single by Texas Rangers first baseman Jake Burger (not pictured) during the third inning at Daikin Park. Mandatory Credit: Troy Taormina-Imagn Images

MATCHUP Houston Astros Los Angeles Angels
Team Records 86-75 72-90
Where Angel Stadium, Anaheim, California
When Sunday, September 28, 2025
Time 03:07 PM EDT
TV MLB.TV

In this article, we will formulate an Astros vs Angels Prediction for this MLB game on Sunday, September 28th at the Angel Stadium in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 72-89 record this season and are sitting on the 4th place of the AL West. The Angels have a 39-41 home record and 87-71 in over/under They are coming off a 1-6 home defeat by the Astros, and are 3-8 in their last 11 games. Under is 5-2 in their last 7 games.

The Angels have a .225 batting average this season, .298 OBP and .398 Slugging percentage. LA’s pitching staff has a 4.88 ERA and 1.43 WHIP. Taylor Ward leads the Angels with 132 hits, while Nolan Schanuel is the team’s best hitter with a .264 batting average. Taylor Ward leads the team with 103 RBI, while Jo Adell adds a team-high 37 home runs.

Sam Aldegheri (R) is the projected starting pitcher for the Angels, and he has a 0-1 record, 8.00 ERA and 2.22 WHIP.

Houston Astros Preview

The Houston Astros have an 86-75 record this season and are sitting on the second place of the AL West. The Astros have a 40-40 road record and 73-82 in over/under. They are coming off a 6-1 road victory over the Angels, and are 2-6 in their last 8 games. Under is 4-1 in their last 5 games.

The Astros have a .250 batting average this season, .315 OBP and .397 slugging percentage. Houston’s pitching staff has a 3.88 ERA and 1.23 WHIP. Jose Altuve leads the Astros with 156 hits, while Jeremy Pena is the team’s best hitter with a .304 batting average. Christian Walker leads the team in RBI with 88, adding a team-high 27 home runs 

Lance McCullers Jr. (R) is the projected starting pitcher for the Astros, and he has a 2-5 record, 6.71 ERA and 1.85 WHIP.

Houston Astros @ Los Angeles Angels Betting Trends: September 28, 2025

Why the Los Angeles Angels will win

Why the Houston Astros will win

Total Runs Facts

Los Angeles Angels Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Astros vs Angels Prediction

The Angels are 3-2 in their last 5 meetings against the Astros, but the Astros are 3-2 in their last 5 meetings in LA. Under is 5-1 in their last 6 meetings.  

The Astros got eliminated from the playoffs even though they won yesterday, so there should be disappointment in their ranks today. They are putting Lance McCullers on the mound, who has been terrible this season, and coming into this matchup in atrocious form, with a 9.95 ERA in his last 5 starts. Aldegheri has been bad in his only start for the Angels, and I expect a lot of runs in the final game of the season for both teams. Take the over the total.

Nikos Lagouretos's Pick: Over

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