Houston Astros vs Los Angeles Angels Prediction 7/29/2026 Today’s MLB Picks

The Houston Astros and the Los Angeles Angels meet Wednesday in MLB action from Angel Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Los Angeles Angels prediction.

Starting Pitching Matchup

The Houston Astros will send out Hayden Wesneski for the start here and Wesneski is making his season debut in this game. The Angels will start Grayson Rodriguez here and Rodriguez is 3-3 with an 8.54 ERA and 30 strikeouts this season.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their 3-2 win over the Angels from Tuesday’s matchup to sit at 54-55 this season. After this series, the Astros will head home for a series against the Rangers.

Astros Win 7 Of Their Last 8

Yordan Alvarez has 123 hits with 20 doubles, 34 home runs and 77 RBIs while Christian Walker has 88 hits with 20 doubles, 20 home runs and 61 RBIs on the year. Jose Altuve’s chipped in 74 hits with 14 doubles, 12 home runs and 30 RBIs and Isaac Paredes has 95 hits with 18 doubles, 14 home runs and 57 RBIs. Cam Smith also has 71 hits with 13 doubles, 13 home runs and 36 RBIs.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to shake off their loss at the hands of the Astros on Tuesday to sit at 42-66 on the year. After this series, the Angels will take on the Milwaukee Brewers in a series at home.

Angels Drop 5 Of Last 6

Nolan Schanuel has 89 hits with 17 doubles, 6 homers and 36 RBIs while Mike Trout’s added 77 hits with 15 doubles, 18 home runs and 40 RBIs this season. Zach Neto’s also added 95 hits with 21 doubles, 19 homers and 46 RBIs and Jo Adell has 98 hits with 15 doubles, 16 home runs and 59 RBIs as well this season. Oswald Peraza has 65 hits with 11 doubles, 7 home runs and 24 RBIs and Jorge Soler has 61 hits with 14 doubles, 12 home runs and 47 RBIs as well this season.

Houston Astros @ Los Angeles Angels Betting Trends: July 29, 2026

• Probable Starting Pitcher: Grayson Rodriguez      Record this season: 3-3      ERA: 8.54
• Home Record: 1-3
• Last 5 against Astros: 0-1

Why the Los Angeles Angels will win

• The Astros have lost seven of their last nine games as favorites against AL West opponents following a road win.
• The Angels have won nine of their last 12 games as home underdogs against AL West opponents following a home loss.
• The Astros have failed to cover the run line in each of their last six games as road favorites against AL West opponents.
• The Angels have covered the run line in each of their last six games as home underdogs against AL West opponents following a loss.
• The Angels have led after 3 innings in six of their last seven night games against the Astros.
• The Angels have won the first inning in three of their last four games against the Astros.
• The Astros have trailed after 5 innings in nine of their last 10 games as road favorites.

• Probable Starting Pitcher: Hayden Wesneski       Record this season: –      ERA: –
• Road Record: –
• Last 5 against Angels: 2-0

Why the Houston Astros will win

• The Astros have won each of their last seven night games after playing the previous day.
• The Angels have lost seven of their last eight games against AL West opponents.
• The Angels have failed to cover the run line in four of their last five games after playing the previous day.
• The Astros have covered the run line in four of their last five night games following a win.
• The Angels have trailed after 3 innings in three of their last four games as underdogs.
• The Angels have lost the first inning in each of their last three games as underdogs against American League opponents.
• The Angels have trailed after 5 innings in three of their last four games as underdogs.

Total Runs Facts

• Each of the Angels’ last seven games as underdogs against American League opponents have gone UNDER the total runs line.
• Five of the Astros’ last six games as favorites have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Angels’ last 10 night games against American League opponents.
• There has been at least one run scored in the first inning in 12 of the Astros’ last 13 night games against AL West opponents.

Los Angeles Angels Player Prop Facts

• Vaughn Grissom has hit a home run in two of the Angels’ last three night games.
• Grayson Rodriguez has recorded a win in four of his last five appearances against AL West opponents.
• Grayson Rodriguez has recorded five or more strikeouts in each of his last nine appearances against AL West opponents.
• Vaughn Grissom has recorded at least one hit in each of the Angels’ last 10 night games.
• Mike Trout ranks 5th amongst qualified players for On Base Percentage (.394) this season.

Houston Astros Player Prop Facts

• Jeremy Pena has hit a home run in three of the Astros’ last four games as favorites.
• Hayden Wesneski has recorded a win in each of his last three appearances with his team as a favorite against AL West opponents.
• Yordan Alvarez has recorded two or more hits in each of the Astros’ last four games as favorites.
• Yordan Alvarez ranks 1st in the league in Home Runs (35) this season.

Matchup/League Facts

• The Angels rank 29th in the league for strikeouts against this season (1022).
• The Angels rank 29th in the league for strikeouts against this season (1022).
• The Astros rank 30th in the league for walks allowed this season (469).
• The Astros rank 30th in the league for walks allowed this season (469).

Houston Astros vs. Los Angeles Angels Prediction

I’m on the Astros in this one. I just think this is a case of two teams headed in different directions and I still don’t trust the Angels as far as I can throw them with Rodriguez starting in this one. Houston’s starting their climb back to the postseason and I think that they keep it going with another win here. Give me the Astros.

Chris Ruffolo's Pick: Houston -135