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Houston Astros vs Kansas City Royals Prediction 4/25/25 MLB Picks

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Kansas City Royals (12-14) vs Houston Astros (13-11)

Game Info: Friday, April 25, 2025 at 7:40 pm (Kauffman Stadium)

The Line: Betting Odds: Kansas City Royals +102 / Houston Astros -125 — Over/Under: 8

(Get latest betting odds)

The Houston Astros and Kansas City Royals meet Friday in MLB action at Kauffman Stadium. Here’s a Houston Astros vs Kansas City Royals Prediction. This article will include a Houston Astros vs Kansas City Royals Pick.

Houston Astros Betting Preview

The Houston Astros are 13-11 on the year and play the Tigers, White Sox, and Brewers next. The Houston Astros are batting .236 on the season, have a .310 OBP, and a .349 slugging percentage. The Houston Astros pitching staff has a 3.26 ERA and a 1.08 WHIP. Jose Altuve leads the Houston Astros with 29 hits and 9 RBI, while Jeremy Pena and Isaac Paredes have combined for 43 hits and 21 RBI. 

Hayden Wesneski gets the ball for the Houston Astros, and he is 1-1 with a 3.91 ERA and 25 strikeouts this season. This will be Wesneski’s first career game against the Kansas City Royals.

Kansas City Royals Betting Preview

The Kansas City Royals are 12-14 on the year and play the Rays, Orioles, and White Sox next. The Kansas City Royals are batting .221 on the season, have a .290 OBP, and a .320 slugging percentage. The Kansas City Royals pitching staff has a 3.52 ERA and a 1.26 WHIP. Bobby Witt Jr. leads the Kansas City Royals with 30 hits and 10 RBI while Maikel Garcia and Salvador Perez have combined for 46 hits and 24 RBI.

Seth Lugo gets the ball for the Kansas City Royals, and he is 1-3 with a 3.90 ERA and 21 strikeouts this season. Lugo is 1-2 with a 5.24 ERA and 19 strikeouts in his career against the Houston Astros.

Why the Kansas City Royals will win

Why the Houston Astros will win

Kansas City Royals Player Prop Facts

Houston Astros Player Prop Facts

Houston Astros vs Kansas City Royals Prediction

You can make a case for either the Astros or Royals as they’re putting together their best week of the season. The difference here is the Astros have been more impressive against better competition while the Royals took advantage of the Rockies. If you’re not paying attention, the Rockies suck. Also, the Royals played two games yesterday and played a total of eight pitchers. That can really throw a bullpen off without an off day. Wesneski has given the Astros a chance in all four starts, allowing 16 hits and 10 runs in 23 innings. I’ll lay the cheap price with the Astros on the road.

Randy Chambers's Pick: Houston Astros -125

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