Houston Astros vs Cleveland Guardians Prediction 4/20/2026 Today’s MLB Picks
Chris Ruffolo
Apr 19, 2026; Houston, Texas, USA; Houston Astros second baseman Jose Altuve (27) hits an RBI infield single against the St. Louis Cardinals during the 10th inning at Daikin Park. Mandatory Credit: Erik Williams-Imagn Images
MATCHUP
Houston Astros
Cleveland Guardians
Team Records
8-15
13-10
Spread
+1.5 -207
-1.5 169
Moneyline
+102
-122
Total
Over 7.5 (102)
Under 7.5 (-122)
Where
Progressive Field, Cleveland, Ohio
When
Monday, April 20, 2026
Time
06:10 PM EDT
TV
MLB.TV
The Houston Astros and the Cleveland Guardians meet Monday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Cleveland Guardians prediction.
Starting Pitching Matchup
The Houston Astros will send out Spencer Arrighetti for the start here and Arrighetti is 1-0 with a 1.50 ERA and 10 strikeouts this season. This will be Arrighetti’s second career start against the Guardians. Slade Cecconi will start for Cleveland and is 0-2 with a 5.03 ERA and 18 strikeouts this season. This will be Cecconi’s second career start against the Astros.
Houston Astros Recap
The Houston Astros come into this game looking to bounce back from their 7-5 loss at the hands of the Cardinals on Sunday to sit at 8-15 this season. After this series, the Astros will head home for a set against the New York Yankees.
Astros Lose 4 Straight & 8 Of Last 10
Yordan Alvarez has 27 hits with 7 doubles, 10 home runs and 21 RBIs while Christian Walker has 20 hits with 6 doubles, 4 home runs and 16 RBIs on the year. Jose Altuve’s chipped in 25 hits with 6 doubles, 3 home runs and 8 RBIs and Carlos Correa has 19 hits with 5 doubles, a home run and 10 RBIs. Cam Smith also has 19 hits with 5 doubles, 3 home runs and 10 RBIs. Yainer Diaz also has 12 hits with 2 doubles, a home run and 9 RBIs.
Cleveland Guardians Recap
The Cleveland Guardians come into this game looking to add on to their 8-4 win over the Baltimore Orioles last time out to sit at 13-10 this season. After this series, the Guardians will head on the road for a series against the Toronto Blue Jays.
Guardians Win Back-To-Back Games
Chase DeLauter has 16 hits with 5 doubles, 5 home runs and 12 RBIs while Steven Kwan has 20 hits with 3 doubles, a home run and 8 RBIs and Jose Ramirez has 19 hits with 4 doubles, 6 home runs and 12 RBIs this season. Brayan Rocchio has also added 17 hits with 2 doubles, 3 home run and 14 RBIs this season while Angel Martinez has 17 hits with 4 doubles, 2 homers and 9 RBIs and Rhys Hoskins has added 10 hits with 5 doubles, a home run and 5 RBIs.
Houston Astros @ Cleveland Guardians Betting Trends: April 20, 2026
Probable Starting Pitcher: Slade Cecconi Record this season: 0-2 ERA: 5.03
Home Record: 0-0
Last 5 against Astros: 1-0
Why the Cleveland Guardians will win
The Astros have lost each of their last eight road games.
The Guardians have won each of their last four games against the Astros.
The Astros have failed to cover the run line in seven of their last eight games.
The Guardians have covered the run line in each of their last four games against the Astros.
The Astros have trailed after 3 innings in each of their last seven night games against opponents that held a winning record.
The Astros have lost the first inning in each of their last five road games.
The Astros have trailed after 5 innings in each of their last seven night games against opponents that held a winning record.
Probable Starting Pitcher: Spencer Arrighetti Record this season: 1-0 ERA: 1.50
Road Record: 0-0
Last 5 against Guardians: 0-0
Why the Houston Astros will win
The Guardians have lost each of their last eight night games following a win.
The underdogs have won each of the Astros’ last four games.
The Guardians have failed to cover the run line in each of their last eight night games following a win.
The Astros have covered the run line in each of their last six night games at Progressive Field following a loss.
The Astros have led after 5 innings in 11 of their last 12 night games against the Guardians at Progressive Field.
The Astros have led after 3 innings in eight of their last 10 night games against the Guardians at Progressive Field.
Total Runs Facts
Each of the Astros’ last six night games against American League opponents have gone OVER the total runs line.
Each of the Guardians’ last four games as favorites against the Astros have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last eight games as underdogs.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Guardians’ last seven games as home favorites.
Cleveland Guardians Player Prop Facts
Jose Ramirez has hit a home run in four of the Guardians’ last five games against the Astros.
Brayan Rocchio has recorded at least one hit in each of his last 10 appearances with the Guardians as favorites.
Jose Ramirez ranks 1st in the league in Steals (10) this season.
Houston Astros Player Prop Facts
Yordan Alvarez has hit a home run in four of the Astros’ last five games.
Jose Altuve has recorded two or more hits in each of his last six appearances with the Astros as underdogs against the Guardians.
Yordan Alvarez ranks 1st in the league in Home Runs (10) this season.
Matchup/League Facts
The Guardians rank 1st in the league for strikeouts this season (229).
The Guardians rank T29th in the league for triples this season (0).
The Astros rank 1st in the league for doubles this season (53).
The Astros rank 30th in the league for ERA this season (6.11).
Houston Astros vs. Cleveland Guardians Prediction
I’m on the Guardians here. Plain and simple, until the Astros show me that they can beat anyone not named the Colorado Rockies at home, the Astros have to be on auto fade right now. Cleveland is putting together quality at bats right now and until they get tripped up, the Guardians have to be the play here.
