Houston Astros vs Chicago White Sox Prediction 7/26/2026 Today’s MLB Picks
Chris Ruffolo
Jul 21, 2026; Houston, Texas, USA; Miami Marlins left fielder Heriberto Hernández (13) is safe at second as Houston Astros shortstop Jeremy Pena (3) makes the tag but Houston Astros designated hitter Yordan Alvarez (44) was called for a bulk in the first inning inning at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images
MATCHUP
Houston Astros
Chicago White Sox
Team Records
52-54
54-49
Spread
-1.5 144
+1.5 -175
Moneyline
-108
-111
Total
Over 9.5 (100)
Under 9.5 (-120)
Where
Rate Field, Chicago, Illinois
When
Sunday, July 26, 2026
Time
02:10 PM EDT
TV
ESPN Unlmtd
The Houston Astros and the Chicago White Sox meet Sunday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Chicago White Sox prediction.
Starting Pitching Matchup
The Houston Astros will send out Ronel Blanco for the start here and Blanco is 0-0 with a 7.71 ERA and 8 strikeouts this season. Erick Fedde will start for Chicago here and is 5-6 with a 4.16 ERA and 66 strikeouts this season.
Houston Astros Recap
The Houston Astros come into this game looking to keep pace in the AL West after a competitive series with the White Sox this weekend. After this series, the Astros will head on the road for a series against the Los Angeles Angels.
Astros Looking To Stay Hot
Yordan Alvarez has 123 hits with 20 doubles, 34 home runs and 77 RBIs while Christian Walker has 88 hits with 20 doubles, 20 home runs and 61 RBIs on the year. Jose Altuve’s chipped in 74 hits with 14 doubles, 12 home runs and 30 RBIs and Isaac Paredes has 93 hits with 18 doubles, 14 home runs and 54 RBIs. Cam Smith also has 71 hits with 13 doubles, 13 home runs and 36 RBIs.
Chicago White Sox Recap
The Chicago White Sox come into this game looking to stay in the hunt in the AL Central heading into the final two months of the season. After this series, the White Sox will take on the Yankees in a huge series at home.
White Sox Looking To Keep Foot On The Gas In Division Race
Munetaka Murakami has 54 hits with 20 home runs and 42 RBIs while Miguel Vargas has 90 hits with 24 doubles, a triple, 21 home runs and 61 RBIs and Colson Montgomery has 79 hits with 17 doubles, 24 home runs and 58 RBIs. Luisangel Acuna has 38 hits and Tristan Peters has 78 hits with 21 doubles and 37 RBIs so far this season. Chase Meidroth also has 102 hits with 18 doubles, 7 home runs and 36 RBIs this year.
Houston Astros @ the Chicago White Sox Betting Trends: July 26, 2026
Probable Starting Pitcher: Erick Fedde Record this season: 5-6 ERA: 4.16
Home Record: 2-1
Last 5 against Astros: 0-1
Why the Chicago White Sox will win
The White Sox have won eight of their last nine games against AL West opponents following a home loss.
The Astros have lost each of their last three day games against American League opponents.
The White Sox have covered the run line in each of their last six Sunday home games against AL West opponents.
The Astros have failed to cover the run line in seven of their last nine day games against AL Central opponents following a road win.
The Astros have trailed after 3 innings in five of their last six road day games.
The Astros have trailed after 5 innings in five of their last six day games.
The Astros have lost the first inning in three of their last four games against AL Central opponents.
Probable Starting Pitcher: Ronel Blanco Record this season: 0-0 ERA: 7.71
Road Record: 0-0
Last 5 against White Sox: 0-0
Why the Houston Astros will win
The Astros have won each of their last four games as underdogs against AL Central opponents.
The White Sox have lost seven of their last eight day games following a home loss.
The Astros have covered the run line each of their last seven games against teams that held a winning record.
The White Sox have failed to cover the run line in each of their last five day games against American League opponents following a home loss.
The Astros have led after 3 innings in five of their last six day games against the White Sox at Rate Field.
The Astros have led after 5 innings in four of their last five day games against American League opponents that held a winning record.
Total Runs Facts
Six of the Astros’ last seven road games against American League opponents have gone OVER the total runs line.
Four of the last five games between the Astros and White Sox at Rate Field have gone OVER the total runs line.
There has been at least one run scored in the first inning in each of Erick Fedde’s last six appearances as a starter.
There has been no run scored during the first inning in each of the Astros’ last six day games.
Chicago White Sox Player Prop Facts
Erick Fedde has recorded a win in four of his last five appearances in day games.
Braden Montgomery has recorded at least one hit in each of the White Sox’s last six games against opponents that held a losing record.
Randal Grichuk has hit a home run in two of his last three appearances in day games against AL West teams that held a losing record.
Houston Astros Player Prop Facts
Ronel Blanco has recorded four or more strikeouts in seven of his last eight appearances in day games against teams that held a winning record.
Jeremy Pena has recorded at least one hit in each of the Astros’ last nine games against the White Sox.
Yordan Alvarez has hit a home run in each of the Astros’ last two day games against AL Central opponents that held a winning record.
Matchup/League Facts
The White Sox rank 24th in the league for strikeouts against this season (924).
The White Sox rank 24th in the league for strikeouts against this season (924).
The Astros rank 30th in the league for walks allowed this season (458).
The Astros rank 30th in the league for walks allowed this season (458).
Houston Astros vs. Chicago White Sox Prediction
I’m on the White Sox in this game. I get the case to be made for Houston as the Astros had been playing well as of late, but Fedde has been stronger at home and I think that the White Sox are still playing really well at home as of late and it’s been a big reason why they are where they are this season. I think Chicago takes care of business here so give me the White Sox.
