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Houston Astros vs Chicago White Sox Prediction 7/25/2026 Today’s MLB Picks

Jun 23, 2026; Chicago, Illinois, USA;  Chicago White Sox pitcher Sean Burke (59) delivers the ball during the first inning against the Cleveland Guardians at Rate Field. Mandatory Credit: Matt Marton-Imagn Images

Jun 23, 2026; Chicago, Illinois, USA; Chicago White Sox pitcher Sean Burke (59) delivers the ball during the first inning against the Cleveland Guardians at Rate Field. Mandatory Credit: Matt Marton-Imagn Images

MATCHUP Houston Astros Chicago White Sox
Team Records 51-54 54-48
Spread +1.5 -193 -1.5 158
Moneyline +105 -126
Total Over 8.5 (100) Under 8.5 (-120)
Where Rate Field, Chicago, Illinois
When Saturday, July 25, 2026
Time 07:10 PM EDT
TV MLB.TV
In this article, we will formulate a Rockies vs Brewers Prediction for this MLB matchup on Saturday, July 25th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview


The Chicago White Sox have a 54-48 record this season and are sitting in the 1st place of the AL Central. They have a 31-18 home record and are coming off a 5-9 home loss against the Astros. They will face the Yankees and the Rays next.

The Chicago White Sox have a .240 batting average this season, .318 OBP and .408 Slugging percentage. Chicago’s pitching staff has a 4.13 ERA and 1.31 WHIP. Sam Antonacci is the team’s best hitter with a .281 batting average. Miguel Vargas leads the team in RBI with 61, while Colson Montgomery adds a team-high 24 home runs.

Sean Burke (R) is the projected starting pitcher for the Chicago White Sox, and he has a 7-4 record, 3.20 ERA and 1.13 WHIP.

Houston Astros Preview


The Houston Astros have a 51-54 record this season and are sitting in the 3rd place of the AL West. They have a 25-27 away record and are coming off a 9-5 road win against the White Sox. They will face the Angels and the Rangers next.

The Houston Astros have a .243 batting average this season, .316 OBP and .414 Slugging percentage. Houston’s pitching staff has a 4.71 ERA and 1.39 WHIP. Yordan Alvarez is the team’s best hitter with a .327 batting average, leads the team in RBI with 77, and adds a team-high 34 home runs.

Hunter Brown (R) is the projected starting pitcher for the Houston Astros, and he has a 1-1 record, 4.05 ERA and 1.45 WHIP.

Houston Astros @ the Chicago White Sox Betting Trends: July 25, 2026


Why the Chicago White Sox will win

Why the Houston Astros will win

Total Runs Facts

Chicago White Sox Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Astros vs White Sox Prediction


The Astros have won their last three meetings against the White Sox and two of their last three visits in Chicago.   

In this Astros vs White Sox Prediction, the White Sox are coming as -125 home favorites. I like the White Sox in a bounce back spot at home with a red-hot Sean Burke on the mound, who has given up one run or less in five of his last six starts. On the flip side, Hunter Brown has been in a big slump for the Astros, having given up 13 runs across his last three starts. The White Sox have a better bullpen and have been averaging 7 runs per game against righties in their last 10 games, so take them to win this one at home.

Nikos Lagouretos's Pick: Chicago White Sox ML

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