| MATCHUP | Houston Astros | Chicago Cubs |
|---|---|---|
| Team Records | 20-31 | 29-21 |
| Spread | +1.5 -187 | -1.5 153 |
| Moneyline | +123 | -148 |
| Total | Over 7 (101) | Under 7 (-121) |
| Where | Wrigley Field, Chicago, Illinois | |
| When | Friday, May 22, 2026 | |
| Time | 02:20 PM EDT | |
| TV | Apple TV | |
In this article, we will formulate an Astros vs Cubs Prediction for this MLB matchup on Friday, May 22nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
Chicago Cubs Preview
The Chicago Cubs have a 29-21 record this season and are sitting in the third place of the NL Central. They have a 18-8 home record and are coming off a 5-0 loss against the Brewers. They will face the Pirates and the Cardinals next.
The Cubs have a .242 batting average this season, .338 OBP and .397 Slugging percentage. Chicago’s pitching staff has a 4.07 ERA and 1.23 WHIP. Seiya Suzuki is the team’s best hitter with a .269 batting average. Nico Hoerner leads the team in RBI with 30, while Ian Happ adds a team-high 10 home runs.
Jameson Taillon (R) is the projected starting pitcher for the Cubs, and he has a 2-3 record, 4.97 ERA and 1.20 WHIP.
Houston Astros Preview
The Houston Astros have a 20-31 record this season and are sitting in the fourth place of the AL West. They have a 8-17 away record and are coming off a 4-1 loss against the Twins. They will face the Rangers and the Brewers next.
The Astros have a .246 batting average this season, .321 OBP and .404 Slugging percentage. Houston’s pitching staff has a 5.34 ERA and 1.53 WHIP. Yordan Alvarez is the team’s best hitter with a .303 batting average, also adding a team-high 15 home runs. Christian Walker leads the team in RBI with 31.
Spencer Arrighetti (R) is the projected starting pitcher for the Astros, and he has a 5-1 record, 1.50 ERA and 1.19 WHIP.
In this article, we will formulate an Astros vs Cubs Prediction for this MLB matchup on Friday, May 22nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup. Chicago Cubs Preview The Chicago Cubs have a 29-21 record this season and are sitting in the third place of the NL Central. They have a 18-8 home record and are coming off a 5-0 loss against the Brewers. They will face the Pirates and the Cardinals next. The Cubs have a .242 batting average this season, .338 OBP and .397 Slugging percentage. Chicago’s pitching staff has a 4.07 ERA and 1.23 WHIP. Seiya Suzuki is the team’s best hitter with a .269 batting average. Nico Hoerner leads the team in RBI with 30, while Ian Happ adds a team-high 10 home runs. Jameson Taillon (R) is the projected starting pitcher for the Cubs, and he has a 2-3 record, 4.97 ERA and 1.20 WHIP. Houston Astros Preview The Houston Astros have a 20-31 record this season and are sitting in the fourth place of the AL West. They have a 8-17 away record and are coming off a 4-1 loss against the Twins. They will face the Rangers and the Brewers next. The Astros have a .246 batting average this season, .321 OBP and .404 Slugging percentage. Houston’s pitching staff has a 5.34 ERA and 1.53 WHIP. Yordan Alvarez is the team’s best hitter with a .303 batting average, also adding a team-high 15 home runs. Christian Walker leads the team in RBI with 31. Spencer Arrighetti (R) is the projected starting pitcher for the Astros, and he has a 5-1 record, 1.50 ERA and 1.19 WHIP. Astros vs Cubs Prediction The Cubs are 4-2 in their last 6 meetings against the Astros and have won their last three meetings in Chicago. In this Astros vs Cubs Prediction, the Cubs are coming as -140 home favorites. The Cubs have been struggling mightily lately with a 2-8 record in their last 10 games, but they still are 18-8 at home and are facing an Astros team that is just 8-17 on the road and has the worst bullpen in baseball. Taillon got torched in his last start but this is the perfect bounce-back spot and while Spencer Arrighetti has been great for the Astros, he cannot pitch all 9 innings. Take the Cubs to win this one comfortably and return to the winning column.
Astros vs Cubs Prediction
The Cubs are 4-2 in their last 6 meetings against the Astros and have won their last three meetings in Chicago.
In this Astros vs Cubs Prediction, the Cubs are coming as -140 home favorites. The Cubs have been struggling mightily lately with a 2-8 record in their last 10 games, but they still are 18-8 at home and are facing an Astros team that is just 8-17 on the road and has the worst bullpen in baseball. Taillon got torched in his last start but this is the perfect bounce-back spot and while Spencer Arrighetti has been great for the Astros, he cannot pitch all 9 innings. Take the Cubs to win this one comfortably and return to the winning column.