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Houston Astros vs Athletics Prediction 9/26/2026 Today’s MLB Picks

Sep 19, 2026; Houston, Texas, USA;  Atlanta Braves right fielder Ronald Acuna Jr. (13)  celebrates with Atlanta Braves first baseman Matt Olson (28) and Atlanta Braves third baseman Austin Riley (27)  after defeating the Houston Astros at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

Sep 19, 2026; Houston, Texas, USA; Atlanta Braves right fielder Ronald Acuna Jr. (13) celebrates with Atlanta Braves first baseman Matt Olson (28) and Atlanta Braves third baseman Austin Riley (27) after defeating the Houston Astros at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

MATCHUP Houston Astros Athletics
Team Records 79-81 64-96
Where Sutter Health Park, Sacramento, California
When Saturday, September 26, 2026
Time 09:40 PM EDT
TV MLB.TV
The Houston Astros and Athletics meet Saturday in MLB action at Sutter Health Park. Here’s a Houston Astros vs. Athletics Prediction. This article will include a Houston Astros vs. Athletics Pick.

Houston Astros Betting Preview


The Houston Astros are 79-81 on the year. The Houston Astros are batting .240 on the season, have a .313 OBP, and have a .414 slugging percentage. The Houston Astros’ pitching staff has a 4.51 ERA and a 1.35 WHIP. Yordan Alvarez leads the Houston Astros with 176 hits and 102 RBI, while Isaac Paredes and Jose Altuve have combined for 272 hits and 140 RBI.

Hayden Wesneski gets the ball for the Houston Astros, and he is 5-2 with a 3.50 ERA and 41 strikeouts this season. Wesneski is 2-0 with a 0.75 ERA and 11 strikeouts in his career against the Athletics.

Athletics Betting Preview


The Athletics are 64-96 on the year. The Athletics are batting .246 on the season, have a .318 OBP, and have a .404 slugging percentage. The Athletics’ pitching staff has a 5.44 ERA and a 1.50 WHIP. Jeff McNeil leads the Athletics with 125 hits and 59 RBI, while Lawrence Butler and Henry Bolte have combined for 221 hits and 97 RBI.

Jack Perkins gets the ball for the Athletics, and he is 3-12 with a 5.90 ERA and 131 strikeouts this season. Perkins is 1-1 with a 4.91 ERA and 13 strikeouts in his career against the Houston Astros.

Houston Astros vs Athletics Prediction


I don’t like my pitchers with small sample sizes, so I’m not thrilled to see Wesneski and 54 innings in a big game. However, the Astros need this game if theyre serious about winning the division. The A’s gave up on the season a while ago, and Perkins isn’t somebody I want to back with his 5.90 ERA and 1.45 WHIP. There are no excuses for the Astros in this spot. A veteran team that’s been in must-win contests endless times. Give me the Astros, and I’ll lay the RL to shave down the price.

Randy Chambers's Pick: Houston Astros -1.5

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