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Houston Astros vs Athletics Prediction 9/25/2026 Today’s MLB Picks

Aug 21, 2026; Houston, Texas, USA; Houston Astros center fielder Taylor Trammell (26) walks through the dugout before playing against the Athletics at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

Aug 21, 2026; Houston, Texas, USA; Houston Astros center fielder Taylor Trammell (26) walks through the dugout before playing against the Athletics at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

MATCHUP Houston Astros Athletics
Team Records 78-80 63-95
Where Sutter Health Park, Sacramento, California
When Friday, September 25, 2026
Time 09:40 PM EDT
TV MLB.TV
The Houston Astros and the Athletics will meet Friday night in an American League West matchup at Sutter Health Park in West Sacramento, California. Let’s take a look at this matchup from a betting perspective.

Houston Astros Betting Preview

The Houston Astros enter Friday’s contest with a 79-80 overall record (2nd in the American League West) and a 40-38 mark on the road. The Astros offense has been solid this season. Houston has compiled 705 runs scored (14th in MLB), 180 home runs and a .243 team batting average which ranks 15th in Major League Baseball.    

Houston arrives at this contest in below average form. The Astros have lost four of the team’s last six games, including a 7-0 shutout victory over the Seattle Mariners three days ago.

The Astros will turn to right hander Hayden Wesneski in this game. In 10 starts made in 2026, Wesneski has compiled a 5-2 win-loss record, a 3.50 ERA, a 1.15 WHIP and 41 strikeouts in 54 innings pitched. Hayden Wesneski has pitched well recently, allowing one earned run or fewer in four of his last six starts made this season. Wesneski will look to continue his recent quality performances on the mound in tonight’s matchup with the Athletics.

The Houston Astros lineup features outfielder Yordan Alvarez and first baseman Christian Walker. Yordan Alvarez has compiled a .316 batting average (1st in MLB), 41 home runs (3rd in MLB),102 RBIs and a 1.035 OPS which ranks first in Major League Baseball. Christian Walker has tallied 25 home runs, 80 RBIs and a .704 OPS.                                                                     

Athletics Betting Preview

The Athletics enter Friday’s contest with a 63-96 overall record (4th in the American League West) and a 31-47 mark at home. The Athletics arrive at this contest in good form, winning two of the team’s last three games played this season, including a 9-7 win over the Los Angeles Angels earlier this week.

The Athletics will start left hander Jacob Lopez in this contest. In 23 starts made this season, Lopez has compiled a 6-5 win-loss record, a 5.68 ERA, a 1.53 WHIP and 108 strikeouts in 117.1 innings pitched. Jacob Lopez arrives at this contest in poor form, allowing five earned runs or more in two consecutive starts made in 2026.  

Offensively, the Athletics lineup features talented catcher Shea Langeliers, who has amassed a .263 batting average, 23 home runs, 55 RBIs, 20 doubles, 35 walks and an .811 OPS.                          

Why the Houston Astros will win.

• Starting pitching. In 10 starts made in 2026, Hayden Wesneski has compiled a 5-2 win-loss record, a 3.50 ERA, a 1.15 WHIP and 41 strikeouts in 54 innings pitched.

• Offensive firepower. Designated hitter Yordan Alvarez has amassed a .316 batting average (1st in MLB), 41 home runs (3rd in MLB),102 RBIs and a 1.035 OPS which ranks first in Major League Baseball.   

 • Motivation. The Houston Astros have lost four of the team’s last six games.

Why the Athletics will win.

• Starting pitching. In 29 appearances made this season, Jacob Lopez has compiled a 6-5 win-loss record, a 5.68 ERA, a 1.53 WHIP and 108 strikeouts in 117.1 innings pitched.

• Offensive potential. Catcher Shea Langeliers has been a key contributor for the Athletics in 2026.    

• Current form. The Athletics have won two of the team’s last three games.

Houston Astros vs. Athletics Prediction

In my opinion, this matchup favors the Houston Astros. Why? Houston starting pitcher Hayden Wesneski has pitched well recently, allowing one earned run or fewer in four of his last six starts made this season, while Athletics hurler Jacob Lopez arrives at this contest in poor form, allowing five earned runs or more in two consecutive starts made in 2026. With that said, the Astros are the side to be on in this contest. I am backing the Houston Astros on the moneyline in this game.

Hans Geevers's Pick: Houston Astros ML

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