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Houston Astros vs Athletics Prediction 4/5/2026 Today’s MLB Picks

Apr 4, 2026; West Sacramento, California, USA; The Houston Astros celebrates their win over the Athletics in a baseball game at Sutter Health Park. Mandatory Credit: Scott Marshall-Imagn Images

Apr 4, 2026; West Sacramento, California, USA; The Houston Astros celebrates their win over the Athletics in a baseball game at Sutter Health Park. Mandatory Credit: Scott Marshall-Imagn Images

MATCHUP Houston Astros Oakland Athletics
Team Records 6-3 2-6
Spread -1.5 114 +1.5 -137
Moneyline -133 +110
Total Over 10 (-112) Under 10 (-108)
Where Sutter Health Park, Sacramento, California
When Sunday, April 5, 2026
Time 04:05 PM EDT
TV MLB.TV

The Houston Astros and Athletics meet Sunday in MLB action at Sutter Health Park. Here’s a Houston Astros vs. Athletics Prediction. This article will include a Houston Astros vs. Athletics Pick.

Houston Astros Betting Preview

The Houston Astros are 6-3 on the year and play the Rockies and Mariners next. The Houston Astros are batting .283 on the season and have a .391 OBP, and a .479 slugging percentage. The Houston Astros pitching staff has a 4.84 ERA and a 1.40 WHIP. Yordan Alvarez leads the Houston Astros with 11 hits and 8 RBI, while Christian Walker and Jose Altuve have combined for 20 hits and 13 RBI.

Lance McCullers Jr. gets the ball for the Houston Astros, and he is 1-0 with a 1.29 ERA and 9 strikeouts this season. McCullers is 7-3 with a 3.32 ERA and 98 strikeouts in his career against the Athletics.

Athletics Betting Preview

The Athletics are 2-6 on the year and play the Yankees and Mets next. The Athletics are batting. 201 on the season, have a .262 OBP, and have a .326 slugging percentage. The Athletics pitching staff has a 5.14 ERA and a 1.73 WHIP. Max Muncy leads the Athletics with 9 hits and 5 RBI while Jacob Wilson and Shea Langeliers have combined for 16 hits and 11 RBI.

Jacob Lopez gets the ball for the Athletics, and he is 0-1 with a 6.75 ERA and 0 strikeouts this season. Lopez is 0-0 with a 0.87 ERA and 13 strikeouts in his career against the Houston Astros.

Why the Athletics will win

Why the Houston Astros will win

Total Runs Facts

Athletics Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Houston Astros vs Athletics Prediction

McCullers was solid in his season debut and it will be interesting to see if he can build on it. McCullers has shown he can be an all-star caliber pitcher when right. The Athletics were supposed to be a fun, high-scoring team this season and while the season is still young, they’ve been anything but. Until the Athletics start stringing something together, they’re a tough sell. I’m going to side with the Astros to keep things rolling and I’ll lay the RL to shave down the juice.

Randy Chambers's Pick: Houston Astros -1.5

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