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Guardians vs White Sox Prediction 07/13/2025 Picks

Jul 3, 2025; Los Angeles, California, USA; Chicago White Sox starting pitcher Aaron Civale (43) throws a pitch during the second inning against the Los Angeles Dodgers at Dodger Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Jul 3, 2025; Los Angeles, California, USA; Chicago White Sox starting pitcher Aaron Civale (43) throws a pitch during the second inning against the Los Angeles Dodgers at Dodger Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Cleveland (45-49) vs Chicago (32-64)

July 13, 2025 at 02:10 PM EDT

The Line: Betting Odds: Chicago +1.5 — Over/Under: +8.5

(Get latest betting odds)

In this article we will formulate a Guardians vs White Sox prediction for this MLB game on Sunday, July 13th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview
The Cleveland Guardians are 45-49 this season after they won two of the first three games in this series by scores of 4-2, 4-5, and 6-2. In their game three win, Cleveland was tied at two in the fourth inning, but they scored the last four runs in the game to pull away in the victory. The Guardians recorded seven hits in the game and they were led by Kwan, who went 1-4 with two RBIs in the win. Cleveland started Bibee, who allowed six hits and two earned runs over 5.2 innings for the win, while Smith and Sabrowski each picked up a hold.
 
Prior to this series, the Guardians swept the Astros in three games, but lost all three against the Tigers before that. Cleveland has won five of their last six games and they are currently fourth in the AL Central standings. The Cleveland pitching staff has a 3.91 ERA with a 1.34 WHIP and a .245 opponent batting average, while the offense has scored 347 runs with a .223 batting average and a .295 on base percentage this season. Jose Ramirez has led Cleveland with 18 home runs and 48 RBIs, while Kyle Manzardo has added 14 home runs and 34 RBIs this year. The projected starting pitcher for Cleveland is Joey Cantillo, who is 1-0 with a 3.79 ERA and a 1.46 WHIP over 35.2 innings pitched this season. 

Chicago White Sox Betting Preview
The Chicago White Sox are 32-64 this year after they lost game three by a score of 2-6 on Saturday afternoon. Chicago scored two runs in the fourth inning to tie the game, but they went scoreless over the last five innings for the loss. The White Sox recorded six hits and they committed one error in the game, while they were led by Teel, who went 1-4 with two RBIs in the loss. Chicago started Burke, who allowed three hits and two earned runs over 5.0 innings, while Leasure picked up the loss in relief. 

Prior to this series, the White Sox lost two out of three against the Blue Jays, but did win two out of three against the Rockies before that. Chicago has lost five of their last seven games and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.15 ERA with a 1.39 WHIP and a .253 opponent batting average, while the offense has scored 327 runs with a .220 batting average and a .295 on base percentage this season. Miguel Vargas has led Chicago with 10 home runs and 35 RBIs, while Andrew Benintendi has added 10 home runs and 34 RBIs this year. The projected starting pitcher for Chicago is Aaron Civale, who is 1-6 with a 5.17 ERA and a 1.55 WHIP over 47.0 innings pitched this year.

Why the Guardians will beat the White Sox
The White Sox have lost each of their last eight day games against American League opponents that held a losing record.
The Guardians have won nine of their last 10 games against the White Sox.
The Guardians have covered the run line in each of their last six road games against American League opponents after playing the previous day.
The White Sox have failed to cover the run line in 10 of their last 12 games at Rate Field against AL Central opponents that held a losing record.
The Guardians have led after 5 innings in seven of their last eight Sunday games as favorites.

Total Runs Facts
Eight of the White Sox’s last nine day games after playing the previous day have gone UNDER the total runs line.
Six of the Guardians’ last seven day games as favorites have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last nine Sunday day games against American League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the last five games between the Guardians and White Sox.

Chicago White Sox Player Prop Facts
Luis Robert has recorded at least one hit in eight of his last nine appearances against the Guardians at Rate Field.
Aaron Civale has recorded four or more strikeouts in 11 of his 12 previous appearances in day games against AL teams that held a losing record.
Luis Robert has hit a home run in three of his last 11 appearances with the White Sox as home underdogs against the Guardians.

Cleveland Guardians Player Prop Facts
Steven Kwan has recorded at least one hit in 15 of his last 16 road appearances against AL Central opponents.
Jose Ramirez has hit a home run in four of the Guardians’ last six road games against AL opponents. 

Guardians vs White Sox Prediction 
Cleveland comes into this contest sitting in fourth place of the AL Central standings, but they are the much better team and they are looking for the series win here. The Guardians are 25-26 on the road this season, while the White Sox are 21-28 at home. Chicago is starting Civale, who has allowed 5, 2, 1, and 5 earned runs in his last four outings. Cleveland is going with Cantillo, who has been decent, but doesn’t pitch very deep into games. I do think Civale is the better option on the mound, but I have to fade the White Sox at this reasonable price. Take Cleveland here. 

David Racey's Pick: Guardians ML

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