Guardians vs Tigers Prediction 9/16/2025 Today’s MLB Picks

In this article we will formulate a Guardians vs Tigers prediction for this MLB game on Tuesday, September 16th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 78-71 this year after they won all three games against the White Sox by scores of 4-0, 3-1, and 3-2. In their game three win, Cleveland blew a 2-1 lead in the fifth, but got the winning run in the seventh for the victory. The Guardians recorded six hits in the game and they were led by Naylor, who went 2-3 with one home run and three RBIs in the win. Cleveland started Cecconi, who allowed three hits and two earned runs over 5.2 innings, while Festa got the win and Smith picked up the save. 

Prior to that series, the Guardians won three out of four against the Royals and three out of four against the Rays. Cleveland has won nine of their last ten games and they are just 6.5 games back in the AL Central. The Cleveland pitching staff has a 3.79 ERA with a 1.29 WHIP and a .242 opponent batting average, while the offense has scored 580 runs with a .225 batting average and a .296 on base percentage this season. Jose Ramirez has led Cleveland with 28 home runs and 77 RBIs, while Kyle Manzardo has added 26 home runs and 67 RBIs this year. The projected starting pitcher for Cleveland is Joey Cantillo, who is 5-3 with a 3.36 ERA and a 1.31 WHIP over 80.1 innings pitched this year. 

Detroit Tigers Betting Preview

The Detroit Tigers are 85-65 this season after they lost two out of three against Miami by scores of 2-8, 4-6, and 2-0. In their game three win, Detroit scored twice in the second inning, which was enough to get the shutout victory. The Tigers recorded four hits in the game and they were led by Dingler, who went 1-4 with one RBI in the win. Detroit started Montero, who allowed three hits and zero earned runs over 5.0 innings for the win, while Vest picked up the save. 

Prior to that series, the Tigers won two out of three against the Yankees, but lost two out of three against the White Sox before that. Detroit has lost three of their last four games and they are currently first in the AL Central standings. The Detroit pitching staff has a 3.91 ERA with a 1.24 WHIP and a .240 opponent batting average, while the offense has scored 729 runs with a .249 batting average and a .318 on base percentage this season. Riley Greene has led Detroit with 34 home runs and 108 RBIs, while Spencer Torkelson has added 28 home runs and 72 RBIs this year. The projected starting pitcher for Detroit is Casey Mize, who is 14-5 with a 3.83 ERA and a 1.27 WHIP over 131.2 innings pitched this season. 

Why the Tigers will beat the Guardians 

The Tigers have won seven of their last eight night games at Comerica Park following a road win.
The Guardians have lost each of their last four road games against American League opponents following a home win.
The Guardians have failed to cover the run line in 10 of their last 11 games against the Tigers following a home win.
The Tigers have covered the run line in 12 of their last 14 home games against the Guardians following a win.

Why the Guardians will beat the Tigers

The Tigers have lost each of their last four games as favorites against AL Central opponents following a win.
The Guardians have won each of their last four games as road underdogs against AL Central opponents following a home win.
The Guardians have covered the run line in nine of their last 10 night games against AL Central opponents that held a winning record.
The Tigers have failed to cover the run line in each of their last four games at Comerica Park following a win.
The Tigers have lost the first inning in three of their last four night games.

Total Runs Facts

Each of the Guardians’ last six games against AL Central opponents have gone UNDER the total runs line.
Six of the Tigers’ last seven games have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Guardians’ last five road games against AL Central opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the last seven night games between the Guardians and Tigers at Comerica Park.

Detroit Tigers Player Prop Facts

Spencer Torkelson has hit a home run in each of the Tigers’ last two games at Comerica Park against AL Central opponents that held a winning record.
Parker Meadows has recorded at least one hit in each of his last 17 appearances in night games against teams that held a winning record.
Casey Mize has recorded a win in three of his last four home appearances.
Jake Rogers has recorded a Double in each of his last three appearances with the Tigers as favorites against AL Central opponents.

Cleveland Guardians Player Prop Facts

Jose Ramirez has recorded at least one hit in each of the Guardians’ last nine games as road underdogs against AL Central opponents.
Austin Hedges has hit a home run in two of his last three road appearances against AL opponents that held a winning record.
Jose Ramirez has recorded a Double in three of the Guardians’ last four games as underdogs against AL opponents.

Guardians vs Tigers Prediction 

These two teams come into this matchup battling at the top of the AL Central standings, but Cleveland probably needs a sweep to stay in the race. The Tigers are 46-29 at home this year, while the Guardians are 37-37 on the road. Cleveland is one of the hottest teams in the MLB right now and they are starting Cantillo, who has allowed one earned run or fewer in four straight starts. Detroit is going with Mize, who has allowed two earned runs or fewer in two straight. I really like how Cantillo is pitching, but the Cleveland offense is simply not good. Take the under here.