Guardians vs Tigers Prediction 5/20/2026 Today’s MLB Picks

In this article we will formulate a Guardians vs Tigers prediction for this MLB game on Wednesday, May 20th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 28-22 this season after they won the first two games in this series by scores of 8-2 and 4-3. In game two, Cleveland blew a 3-2 lead in the fourth, but they scored in the seventh to get the win. The Guardians recorded four hits and they committed one error in the game, while they were led by Bazzana, who went 2-3 with one home run and two RBIs. Messick allowed four hits and two earned runs over 5.0 innings, while Holderman got the win and Smith picked up the save. Prior to this series, Cleveland won two out of three against the Reds and all three against the Angels. 

This season, Cleveland has a 3.78 ERA with a 1.27 WHIP and a .236 opponent batting average, while they have scored 222 runs with a .231 batting average and a .327 on base percentage. Chase DeLauter has led the Guardians with seven home runs and 30 RBIs, while Jose Ramirez has added eight home runs and 22 RBIs. The projected starting pitcher for Cleveland is Tanner Bibee, who is 0-6 with a 4.15 ERA and a 1.35 WHIP over 52.0 innings pitched this season. 

Detroit Tigers Betting Preview

The Detroit Tigers are 20-29 this year after they lost game two by a score of 4-3 on Tuesday night. Detroit led 2-1 in the second inning and they tied the game at three in the fourth, but they failed to score in the last five innings for the loss. The Tigers recorded seven hits in the game and they were led by Torkelson, who went 1-3 with one home run and two RBIs. Montero allowed two hits and three earned runs over 5.0 innings, while Holton picked up the loss in relief. Prior to this series, Detroit lost two out of three against the Blue Jays and all three against the Mets. 

This season, Detroit has a 4.03 ERA with a 1.29 WHIP and a .238 opponent batting average, while they have scored 193 runs with a .238 batting average and a .321 on base percentage. Dillon Dingler has led the Tigers with eight home runs and 28 RBIs, while Riley Greene has added four home runs and 24 RBIs. The projected starting pitcher for Detroit is TBD.

Why the Detroit Tigers will win

• The Guardians have failed to cover the run line in nine of their last 11 road games following a road win.
• The Tigers have covered the run line in three of their last four night games against American League opponents.

Why the Cleveland Guardians will win

• The Guardians have won each of their last eight night games against the Tigers at Comerica Park following a win.
• The Tigers have lost each of their last seven night games against the Guardians following a home loss.
• The Guardians have covered the run line in each of their last eight Wednesday night road games.
• The Tigers have failed to cover the run line in each of their last six Wednesday night home games against American League opponents.
• The Tigers have trailed after 3 innings in four of their last five home night games.
• The Tigers have trailed after 5 innings in four of their last five night games at Comerica Park against American League opponents.

Total Runs Facts

• Five of the Tigers’ last six home games against American League opponents have gone UNDER the total runs line.
• Three of the Guardians’ last four games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last six Wednesday games at Comerica Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Guardians’ last six games at Comerica Park.

Detroit Tigers Player Prop Facts

• Spencer Torkelson has hit a home run in three of the Tigers’ last four games at Comerica Park against opponents that held a winning record.
• Riley Greene has recorded at least one hit in each of the Tigers’ last eight games against the Guardians.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit at least one home run in three of the Guardians’ last four games at Comerica Park against AL Central opponents that held a losing record.
• Rhys Hoskins has recorded at least one hit in each of his last five appearances against the Tigers.

Guardians vs Tigers Prediction 

Cleveland was able to get another win on Tuesday night and they have won four games in a row. The Guardians are 13-12 on the road this year, while the Tigers are 13-10 at home. Detroit has lost four in a row and they continue to fall in the AL Central standings. The Tigers have not announced their pitching plans for this game, but Cleveland is starting Bibee, who has allowed two earned runs or fewer in three of his last five starts. All signs point to the Guardians in this game, but they have lost nine Bibee starts in a row. Take the Tigers here.

David Racey's Pick: Tigers ML