Guardians vs Reds Prediction 5/17/25 MLB Picks

In this article, we will formulate a Guardians vs Reds prediction for this MLB game on Saturday, May 17th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 25-19 this year after they lost the first game in this series by a score of 5-4. Cleveland allowed the first five runs in the game, but they did score the last four before their comeback attempt fell short. The Guardians recorded five hits and they committed one error in the game, while they were led by Santana, who went 1-4 with two RBIs in the loss. Cleveland started Bibee, who allowed 10 hits and four earned runs over 6.0 innings for the loss, while Festa finished the last two innings in relief. 

Prior to this series, the Guardians won two out of three against the Brewers, but did lose two out of three against the Phillies before that. Cleveland has lost four of their last six games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 4.15 ERA with a 1.41 WHIP and a .259 opponent batting average, while the offense has scored 180 runs with a .232 batting average and a .307 on-base percentage this season. Kyle Manzardo has led Cleveland with 10 home runs and 25 RBIs, while Jose Ramirez has added nine home runs and 23 RBIs this year. The projected starting pitcher for Cleveland is Slade Cecconi, who is making his season debut here. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 22-24 this season after they won game one by a score of 5-4 on Friday night. Cincinnati scored five runs in the first three innings, but their offense didn’t do much after that, and they barely got the win. The Reds recorded 11 hits in the game, and they were led by Benson, who went 2-4 with one home run and three RBIs in the win. Cincinnati started Singer, who allowed three hits and three earned runs over 5.0 innings for the win, while Pagan picked up the save. 

Prior to this series, the Reds lost two out of three against the White Sox and two out of three against the Astros. Cincinnati has lost five of its last eight games, and they are currently third in the NL Central standings. The Cincinnati pitching staff has a 3.70 ERA with a 1.17 WHIP and a .221 opponent batting average, while their offense has scored 213 runs with a .241 batting average and a .320 on-base percentage this season. Elly De La Cruz has led Cincinnati with eight home runs and 31 RBIs, while Austin Hays has added six home runs and 16 RBIs this year. The projected starting pitcher for Cincinnati is Brent Suter, who is 1-0 with a 2.08 ERA and a 0.92 WHIP over 21.1 innings pitched this season. 

Why the Guardians will beat the Reds

• The Reds have lost seven of their last eight home games against AL Central opponents following a home win.
• The Guardians have won six of their last seven night games against National League opponents that held a losing record.
• The Reds have failed to cover the run line in nine of their last 10 home games against AL Central opponents following a home win.
• The Guardians have covered the run line in each of their last five night games against NL Central opponents following a road loss.
• The Reds have trailed after 5 innings in five of their last six home games against AL Central opponents that held a winning record.

Total Runs Facts

• Each of the last six games between the Guardians and Reds have gone UNDER the total runs line.
• Six of the Guardians’ last seven night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Guardians’ last nine games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the last 10 night games between the Guardians and Reds at Great American Ball Park.

Cincinnati Reds Player Prop Facts

• Will Benson has hit a home run in each of the Reds’ last two home games against AL Central opponents.
• Jeimer Candelario has recorded at least one RBI in each of his last four home appearances against the Guardians.
• Spencer Steer has recorded a Double in four of the Reds’ last five games.
• Spencer Steer has recorded at least one hit in each of the Reds’ last nine games at Great American Ball Park.
• Tyler Stephenson has recorded at least one Single in each of his last five home appearances against AL opponents that held a winning record.
• Elly De La Cruz has scored at least one run in four of the Reds’ last five home games against AL opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 13 games against NL opponents that held a losing record.
• Jose Ramirez has recorded at least one Single in each of his last five road appearances after playing the previous day.
• Jose Ramirez has scored at least one run in each of the Guardians’ last six games against opponents that held a losing record.
• Jose Ramirez has hit a home run in each of the Guardians’ last three games against NL Central opponents.
• Jose Ramirez has recorded at least one RBI in four of the Guardians’ last five games against opponents that held a losing record.

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Guardians vs Reds Prediction 

Cincinnati was able to start this series with a close victory on Friday night, but they have really struggled over the last two weeks. The Reds are just 11-12 at home this year, while the Guardians are 11-11 on the road. Cincinnati is going with Suter, who should only go one or two innings, while Cleveland is starting Cecconi, who is making his first appearance of the season. Once Suter is done for the Reds, Petty is expected to be the bulk reliever, but he has really struggled in limited work. Take the Guardians to get the win here.