San Francisco (57-57) vs Pittsburgh (49-65)
August 6, 2025 at 12:35 PM EDT
The Line: Betting Odds: Pittsburgh +1.5 — Over/Under: +7.5
In this article we will formulate a Giants vs Pirates prediction for this MLB game on Wednesday, August 6th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup.
San Francisco Giants Betting Preview
The San Francisco Giants are 57-57 this year after they split the first two games in this series by scores of 4-5 and 8-1. In their game two win, San Francisco had their lead cut to 2-1, but they scored the last six runs to pull away with the easy victory. The Giants recorded 11 hits in the game and they were led by Bailey, Koss, and Adames, who all had two RBIs in the win. San Francisco started Webb, who allowed seven hits and one earned run over 6.0 innings for the win, while Gage and Beck finished the game.
Prior to this series, the Giants won two out of three against the Mets, but got swept by the Pirates before that. San Francisco has alternated wins and losses over their last six games and they are currently third in the NL West standings. The San Francisco pitching staff has a 3.67 ERA with a 1.28 WHIP, and a .242 opponent batting average, while the offense has scored 477 runs with a .234 batting average and a .312 on base percentage this season. Wilmer Flores has led San Francisco with 12 home runs and 59 RBIs, while Willy Adames has added 18 home runs and 61 RBIs this year. The projected starting pitcher for San Francisco is Robbie Ray, who is 9-5 with a 2.85 ERA and a 1.12 WHIP over 136.0 innings pitched this year.
Pittsburgh Pirates Betting Preview
The Pittsburgh Pirates are 49-65 this season after they lost game two on Tuesday night. Pittsburgh scored their lone run in the third inning, but went scoreless in the last six innings for the defeat. The Pirates recorded seven hits and they committed two errors in the game, while they were led by Reynolds, who went 2-4 with one RBI in the loss. Pittsburgh started Burrows, who allowed five hits and six earned runs over 4.2 innings for the loss, while Ashcraft allowed two earned runs in relief.
Prior to this series, the Pirates lost two out of three against the Rockies, but did sweep the Giants before that. Pittsburgh has lost three of their last five games and they are currently last in the NL Central standings. The Pittsburgh pitching staff has a 3.88 ERA with a 1.22 WHIP and a .236 opponent batting average, while their offense has scored 405 runs with a .232 batting average and a .303 on base percentage this season. Oneil Cruz has led Pittsburgh with 18 home runs and 48 RBIs, while Bryan Reynolds has added 10 home runs and 53 RBIs this year. The projected starting pitcher for Pittsburgh is Andrew Heaney, who is 5-9 with a 4.89 ERA and a 1.31 WHIP over 110.1 innings pitched this season.
Why the Giants will beat the Pirates
- The Pirates have lost eight of their last nine games against NL West opponents following a home loss.
- The road team has won six of the last seven games between the Giants and Pirates.
- The Pirates have failed to cover the run line in seven of their last eight day games against NL West opponents following a home loss.
- The road team has covered the run line in six of the last seven games between the Giants and Pirates.
Total Runs Facts
- Seven of the last eight games between the Giants and Pirates at PNC Park have gone OVER the total runs line.
- Each of the Giants’ last five road games after playing the previous day have gone OVER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Pirates’ last seven home games against National League opponents.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Giants’ last 14 road games against NL Central opponents.
Pittsburgh Pirates Player Prop Facts
- Andrew Heaney has recorded four or more strikeouts in each of his last four home appearances against NL opponents.
- Tommy Pham has recorded at least one hit in 14 of his last 15 appearances after playing the previous day.
- Andrew McCutchen has hit a home run in four of his last 10 appearances against NL West opponents.
San Francisco Giants Player Prop Facts
- Jung Hoo Lee has recorded a Double in four of the Giants’ last five road games against NL opponents.
- Matt Chapman has recorded at least one hit in each of his last nine appearances at PNC Park.
- Wilmer Flores has hit a home run in each of his last two appearances in day games against NL Central teams that held a losing record.
Giants vs Pirates Prediction
San Francisco was finally able to beat Pittsburgh on Tuesday night, but they have had a ton of trouble stringing wins together recently. The Giants are 29-31 on the road this year, while the Pirates are 32-26 at home. Pittsburgh has allowed at least five runs in four of their last five games and they are starting Heaney, who has allowed 3, 0, 7, 3, and 4 earned runs in his last five outings. The Giants are going with Ray, who has allowed two earned runs or fewer in four of his last five starts. I can’t back Heaney with how he is pitching, so give me the Giants by at least two here.