Diamondbacks vs Cubs Prediction 4/18/25 MLB Picks

In this article we will formulate a Diamondbacks vs Cubs prediction for this MLB game on Friday, April 18th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 12-7 this year and they have won five games in a row. Arizona is coming off of a series win against Miami, where they won all three games by scores of 10-4, 6-2, 6-4. In that game three win, the Diamondbacks scored two runs in the first inning and they pulled away in the third and fourth innings for the win. Arizona recorded five hits and they committed two errors in the game, while they were led by Smith and Naylor, who both had a home run in the win. Arizona started Rodriguez, who allowed 10 hits and one earned run over 5.1 innings pitched, while Puk allowed one hit in the ninth and got the save. 

Prior to that series, the Diamondbacks won two out of three against the Brewers and two out of three against the Orioles. The Arizona pitching staff has a 4.07 ERA with a 1.20 WHIP and a .227 opponent batting average, while their offense has scored 104 runs with a .254 batting average and a .347 on base percentage this year. Corbin Carroll has led Arizona with six home runs and 17 RBIs, while Geraldo Perdomo has added three home runs and 18 RBIs this season. The projected starting pitcher for Arizona is Corbin Burnes, who is 0-1 with a 5.28 ERA and a 1.57 WHIP over 15.1 innings pitched this year. 

Chicago Cubs Betting Preview

The Chicago Cubs are 12-9 this season and they have won three of their last five games. Chicago is coming off of a series loss to the Padres, where they lost two out of three by scores of 4-10, 2-1, and 2-4. In that game three loss, the Cubs led 1-0 in the third inning, but they allowed two runs in the third and one in the seventh, and came up just short in the late innings. Chicago recorded six hits and they committed one error in the game, while they were led by Tucker and Crow-Armstrong, who both had one RBI in the loss. Chicago started Boyd, who allowed six hits and two earned runs over 5.1 innings, while Palencia allowed one hit and one earned run in 1.2 innings of relief work. 

Prior to that series, the Cubs won two out of three against the Dodgers and two out of three against the Rangers. The Chicago pitching staff has a 4.14 ERA with a 1.38 WHIP and a .251 opponent batting average, while their offense has scored 124 runs with a .255 batting average and a .340 on base percentage this season. Kyle Tucker has led Chicago with five home runs and 19 RBIs, while Seiya Suzuki has added four home runs and 15 RBIs this year. The projected starting pitcher for Chicago is Colin Rea, who is 0-0 with a 1.00 ERA and a 1.11 WHIP over 9.0 innings pitched this year. 

Why the Cubs will beat the Diamondbacks

• The Cubs have won seven of their last eight games as underdogs against National League opponents following a road loss.
• The Diamondbacks have lost three of their last four games as favorites against NL Central opponents following a win.
• The Cubs have covered the run line in each of their last six games as underdogs against the Diamondbacks following a road loss.
• The Diamondbacks have failed to cover the run line in three of their last four games as favorites against NL Central opponents.
• The Diamondbacks have trailed after 5 innings in each of their last four games as favorites against NL Central opponents.

Why the Diamondbacks will beat the Cubs 

• The Diamondbacks have won seven of their last eight games.
• The Cubs have lost three of their last four day games against teams that held a winning record.
• The Diamondbacks have covered the run line in eight of their last nine road games against teams that held a winning record.
• The Cubs have failed to cover the run line in each of their last six games at Wrigley Field following a road loss.

Total Runs Facts

• Each of the Cubs’ last five home games have gone OVER the total runs line.
• Fourteen of the Diamondbacks’ last 18 day games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last six games as underdogs against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last four day games against National League opponents.

Chicago Cubs Player Prop Facts

• Carson Kelly has hit at least one home run in three of his last six appearances after not playing the previous day.
• Nico Hoerner has recorded an RBI in each of his last four home appearances against NL West opponents.
• Ian Happ has scored at least one run in each of the Cubs’ last four home games.
• Nico Hoerner has recorded at least one Single in six of the Cubs’ last seven games at Wrigley Field against NL opponents that held a winning record.
• Seiya Suzuki has recorded two or more hits in each of the Cubs’ last three games at Wrigley Field.
• Kyle Tucker ranks T3rd in the league in Hits (25) this season.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has recorded a Double in each of the Diamondbacks’ last three games against opponents that held a winning record.
• Eugenio Suarez has hit at least one home run in four of the Diamondbacks’ last five games against the Cubs.
• Corbin Burnes has recorded seven or more strikeouts in each of his last six road appearances against NL Central opponents.
• Alek Thomas has scored at least one run in each of his last five appearances against the Cubs.
• Ketel Marte has recorded at least one hit in each of his last nine appearances against NL Central opponents.
• Ketel Marte has recorded at least one RBI in each of his last seven road appearances against NL opponents that held a winning record.
• Ketel Marte has recorded a Single in each of his last six appearances with the Diamondbacks as favorites against NL Central opponents.
• Corbin Carroll ranks T4th in the league in Home Runs (6) this season.

Matchup/League Facts

• The Cubs rank T1st in the league for triples this season (5).
• The Cubs rank 1st in the league for RBIs this season (121).
• The Diamondbacks rank 2nd in the league for walks this season (86).
• The Diamondbacks rank T3rd in the league for runs scored this season (104).

Diamondbacks vs Cubs Prediction 

Arizona comes into this series playing very well over the last week and they have scored at least five runs in five straight games. Chicago is coming off of a series loss to San Diego, but they are one of the highest scoring teams in the MLB so far this year. The Cubs are starting Rea, who isn’t expected to go very deep into this game, and I think Arizona can get to him. On the other side, the Diamondbacks are going with Burnes, who hasn’t been awful, but certainly hasn’t been good through three starts. Take the over here. 

David Racey's Pick: Over 10.5