Cubs vs Reds Prediction 9/19/2026 Today’s MLB Picks

In this article we will formulate a Cubs vs Reds prediction for this MLB game on Saturday, September 19th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 85-69 this season after they lost game one by a score of 4-6 on Friday. Chicago led 4-3 in the fourth inning, but went scoreless over the last five innings for the loss. The Cubs recorded nine hits and they committed one error in the game, while they were led by Suzuki, who went 1-5 with two RBIs. Holmes allowed three hits and six earned runs over 5.1 innings for the loss, while Assad blew the save. Prior to this series, Chicago won two out of three against the Braves and two out of three against the Pirates. 

This season, Chicago has a 4.21 ERA with a 1.27 WHIP and a .245 opponent batting average, while they have scored 821 runs with a .252 batting average and a .340 on base percentage. Pete Crow-Armstrong has led the Cubs with 44 home runs and 105 RBIs, while Dansby Swanson has added 18 home runs and 66 RBIs. The projected starting pitcher for Chicago is Matthew Boyd, who is 8-5 with a 4.16 ERA and a 1.24 WHIP over 114.2 innings pitched this season. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 72-82 this year after they won game one by a score of 6-4 on Friday night. Cincinnati blew an early 3-2 lead, but they scored three runs in the sixth to get the win. The Reds recorded eight hits in the game and they were led by Trevino, who went 1-4 with two RBIs. Burns allowed four hits and two earned runs over 3.0 innings, while Aguiar picked up the win and Pagan got the save. Prior to this series, Cincinnati lost three out of four against the Dodgers and two out of three against the Brewers. 

This season, Cincinnati has a 4.87 ERA with a 1.45 WHIP and a .254 opponent batting average, while they have scored 639 runs with a .230 batting average and a .307 on base percentage. Sal Stewart has led the Reds with 32 home runs and 110 RBIs, while Elly De La Cruz has added 28 home runs and 74 RBIs. The projected starting pitcher for Cincinnati is Nick Lodolo, who is 3-5 with a 5.12 ERA and a 1.49 WHIP over 96.2 innings pitched this year. 

Why the Cincinnati Reds will win

• The Cubs have lost each of their last five road games against NL opponents.
• The Reds have won three of their last four games as underdogs against the Cubs.
• The Cubs have failed to cover the run line each of their last four games against NL opponents that held a losing record.
• The underdogs have covered the run line in four of the last five games between the Cubs and Reds at Great American Ball Park.
• The Reds have led after 3 innings in three of their last four games as home underdogs against NL Central opponents.
• The Reds have won the first inning in three of their last four home games against NL Central opponents.

Why the Chicago Cubs will win

• The Reds have lost each of their last six night games against NL opponents following a win.
• The Cubs have won each of their last six Saturday games against NL opponents that held a losing record.
• The Reds have failed to cover the run line in each of their last nine night games at Great American Ball Park following a win.
• The Cubs have covered the run line in each of their last four games as favorites following a loss.
• The Cubs have led after 3 innings in three of their last four games against the Reds.
• The Reds have trailed after 5 innings in 10 of their last 11 games as underdogs.

Total Runs Facts

• Each of the Cubs’ last five games as favorites against the Reds have gone OVER the total runs line.
• Six of the Reds’ last seven night games against NL Central opponents have gone OVER the total runs line.
• There has been at least one run scored in the first inning in 10 of the Reds’ last 11 games against NL Central opponents.
• There has been at least one run scored in the first inning in nine of the Cubs’ last 10 games as favorites against NL Central opponents.

Cincinnati Reds Player Prop Facts

• Sal Stewart has hit a home run in three of the Reds’ last four games as underdogs against the Cubs.
• Nick Lodolo has recorded six or more strikeouts in six of his last seven home appearances against NL Central opponents.
• Sal Stewart has recorded at least one hit in each of the Reds’ last 19 night games against NL Central opponents that held a winning record.

Chicago Cubs Player Prop Facts

• Matthew Boyd has recorded five or more strikeouts in five of his last six appearances in night games against NL teams that held a losing record.
• Seiya Suzuki has recorded at least one hit in each of the Cubs’ last nine games at Great American Ball Park against NL Central opponents that held a losing record.
• Ian Happ has hit a home run in each of his last two road appearances against opponents that held a losing record.

Cubs vs Reds Prediction 

Cincinnati was able to start this series with a win on Friday and they have won two of their last three games. The Reds are 38-41 at home this year, while the Cubs are 40-36 on the road. Chicago has alternated wins and losses over their last five games and they have scored 7+ runs in two of their last four. The Cubs are starting Boyd, who has allowed 3+ earned runs in four of his last five starts, while Lodolo has allowed 3+ earned runs in four of his last five. Take the over here.

David Racey's Pick: Over 9.5