Cubs vs Pirates Prediction 9/15/2025 Today’s MLB Picks

In this article we will formulate a Cubs vs Pirates prediction for this MLB game on Monday, September 15th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 85-64 this year after they won two out of three against Tampa Bay by scores of 6-4, 4-5, and 4-3. In their game three win, Chicago trailed 3-1 in the third inning, but they scored once in the sixth and twice in the seventh for the victory. The Cubs recorded 10 hits in the game and they were led by Hoerner, who went 2-4 with three RBIs in the win. Chicago started Imanaga, who allowed seven hits and three earned runs over 5.0 innings, while Assad picked up the win and Kittredge got the save. 

Prior to that series, the Cubs won two out of three against the Braves, but lost two out of three against the Nationals before that. Chicago has won four of their last five games and they are second in the NL Central standings. The Chicago pitching staff has a 3.86 ERA with a 1.19 WHIP and a .242 opponent batting average, while their offense has scored 727 runs with a .249 batting average and a .320 on base percentage this season. Seiya Suzuki has led Chicago with 27 home runs and 91 RBIs, while Pete Crow-Armstrong has added 28 home runs and 87 RBIs this year. The projected starting pitcher for Chicago is Jameson Taillon, who is 9-6 with a 4.15 ERA and a 1.11 WHIP over 110.2 innings pitched this year. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 65-85 this season after they lost two out of three against Washington by scores of 5-6, 5-1, and 3-4. In their game three loss, Pittsburgh led 3-0 in the first inning, but went scoreless over the last eight innings for the loss. The Pirates recorded five hits and they committed one error in the game, while they were led by Gonzales, who went 1-4 with two RBIs in the loss. Pittsburgh started Burrows, who allowed five hits and three earned runs over 4.1 innings, while Mattson picked up the loss in relief. 

Prior to that series, the Pirates lost all three against the Orioles and all three against the Brewers. Pittsburgh has lost eight of their last nine games and they are currently last in the NL Central standings. The Pittsburgh pitching staff has a 3.86 ERA with a 1.22 WHIP and a .237 opponent batting average, while their offense has scored 540 runs with a .231 batting average and a .305 on base percentage this season. Oneil Cruz has led Pittsburgh with 19 home runs and 56 RBIs, while Bryan Reynolds has added 15 home runs and 71 RBIs this year. The projected starting pitcher for Pittsburgh is Braxton Ashcraft, who is 4-2 with a 2.47 ERA and a 1.20 WHIP over 58.1 innings pitched this season. 

Why the Cubs will beat the Pirates

The Pirates have lost eight of their last nine games.
The Cubs have won six of their last seven games at PNC Park.
The Pirates have failed to cover the run line in each of their last four home games against NL Central opponents.
The Cubs have covered the run line in five of their last six road games against the Pirates.
The Pirates have trailed after 5 innings in three of their last four night games against NL Central opponents that held a winning record.

Total Runs Facts

Each of the Cubs’ last six night games after playing the previous day have gone UNDER the total runs line.
Six of the last seven games between the Cubs and Pirates have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Pirates’ last seven Monday night games against NL Central opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Cubs’ last seven games as favorites.

Pittsburgh Pirates Player Prop Facts

Jack Suwinski has hit a home run in two of his last three appearances with the Pirates as underdogs against the Cubs.
Oneil Cruz has recorded a Double in four of the Pirates’ last five games against the Cubs at PNC Park.
Oneil Cruz has recorded at least one hit in nine of his last 10 appearances against the Cubs at PNC Park.

Chicago Cubs Player Prop Facts

Jameson Taillon has recorded five or more strikeouts in four of his last five appearances at PNC Park against NL Central opponents that held a losing record.
Seiya Suzuki has hit a home run in each of the Cubs’ last two night games against NL Central opponents that held a losing record.
Ian Happ has recorded a Double in six of the Cubs’ last seven games at PNC Park.
Nico Hoerner has recorded at least one hit in each of the Cubs’ last nine games.
Jameson Taillon has recorded a win in five of his last six appearances against opponents that held a losing record.

Cubs vs Pirates Prediction 

Pittsburgh extended their streak of poor play with another loss on Sunday, as they blew an early 3-0 lead. The Pirates are 42-33 at home this year, while the Cubs are 39-35 on the road. Chicago has won four of their last five games and they are starting Taillon, who has allowed two earned runs or fewer in four straight starts. Pittsburgh is going with Ashcraft, who has allowed one earned run or fewer in five straight outings, but has only pitched six innings in his last two. Take the Cubs to get the win in game one here.