Cubs vs Cardinals Prediction 7/28/2026 Today’s MLB Picks

In this article we will formulate a Cubs vs Cardinals prediction for this MLB game on Tuesday, July 28th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 60-46 this year after they won game one by a score of 7-3 last night. Chicago scored five runs in the first five innings and added two in the ninth to finish the win. The Cubs recorded 14 hits in the game and they were led by Hoerner, who went 4-5 with one home run and four RBIs. Peterson allowed three hits and two earned runs over 5.2 innings for the win, while Hollowell allowed one earned run in relief. Prior to this series, Chicago won two out of three against the Pirates, but lost two out of three against the Tigers before that. 

This season, Chicago has a 4.22 ERA with a 1.27 WHIP and a .246 opponent batting average, while they have scored 548 runs with a .248 batting average and a .339 on base percentage. Dansby Swanson has led the Cubs with 16 home runs and 61 RBIs, while Ian Happ has added 18 home runs and 45 RBIs. The projected starting pitcher for Chicago is Colin Rea, who is 7-7 with a 4.85 ERA and a 1.42 WHIP over 105.2 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 53-53 this season after they lost game one by a score of 3-7 on Monday night. St. Louis cut the deficit to 5-3 in the sixth inning, but couldn’t get any closer in the loss. The Cardinals recorded seven hits and they committed one error in the game, while they were led by Winn, who went 2-4 with one RBI. Liberatore allowed eight hits and three earned runs over 3.2 innings for the loss, while Dobbins allowed six hits and four earned runs over 5.1 relief innings. Prior to this series, St. Louis lost two out of three against the Reds and lost a makeup game with the Diamondbacks. 

This season, St. Louis has a 4.16 ERA with a 1.34 WHIP and a .253 opponent batting average, while they have scored 469 runs with a .240 batting average and a .315 on base percentage. Jordan Walker has led the Cardinals with 22 home runs and 77 RBIs, while Alec Burleson has added 15 home runs and 71 RBIs. The projected starting pitcher for St. Louis is TBD. 

Why the St. Louis Cardinals will win

• The underdogs have won five of the Cardinals’ last six games at Busch Stadium.
• The Cubs have lost three of their last four games as favorites following a win.
• The Cubs have failed to cover the run line in each of their last four road games against the Cardinals following a win.
• The Cardinals have covered the run line in six of their last seven games as underdogs against NL Central opponents following a loss.

Why the Chicago Cubs will win

• The Cardinals have lost each of their last four games against National League opponents that held a winning record.
• The Cubs have won each of their last four night games against National League opponents.
• The Cubs have covered the run line in nine of their last 10 road games after playing the previous day.
• The Cardinals have failed to cover the run line in five of their last six games at Busch Stadium.
• The Cardinals have trailed after 3 innings in three of their last four home games against NL Central opponents that held a winning record.

Total Runs Facts

• Six of the Cubs’ last seven games after playing the previous day have gone OVER the total runs line.
• Eighteen of the Cardinals’ last 23 home games have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of Michael McGreevy’s last four appearances as a starter.
• There has been at least one run scored in the first inning in each of the Cubs’ last six Tuesday games against NL Central opponents.

St. Louis Cardinals Player Prop Facts

• JJ Wetherholt has recorded at least one hit in each of the Cardinals’ last six games as underdogs against the Cubs.
• Michael McGreevy has recorded four or more strikeouts in five of his last six appearances in night games against teams that held a winning record.
• Michael McGreevy has recorded a win in each of his last three appearances with the Cardinals as home underdogs against NL Central opponents.
• Jose Fermin has hit a home run in two of the Cardinals’ last three games against NL Central opponents that held a winning record.

Chicago Cubs Player Prop Facts

• Colin Rea has recorded a win in each of his last three appearances with the Cubs as favorites against the Cardinals.
• Alex Bregman has hit a home run in each of the Cubs’ last two games at Busch Stadium.
• Nico Hoerner has recorded at least one hit in each of the Cubs’ last six games against the Cardinals.
• Colin Rea has recorded five or more strikeouts in six of his last seven appearances with the Cubs as favorites against NL opponents.

Cubs vs Cardinals Prediction

St. Louis comes into this matchup after losing game one on Monday and they have lost four of their last five games. The Cardinals are 27-30 at home this year, while the Cubs are 30-24 on the road. Chicago has won three of their last four games and they have scored 7+ runs in three straight. The Cubs are starting Rea, who has allowed 4, 3, and 3 earned runs in his last three starts, while the Cardinals have not announced their plans. I don’t like how Rea has pitched recently, so I will back the Cardinals at home.

David Racey's Pick: Cardinals ML